Conversion from CUL4-based COP1–SPA E3 apparatus to UVR8–COP1–SPA complexes underlies a distinct biochemical function of COP1 under UV-B [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance CONSTITUTIVE PHOTOMORPHOGENESIS 1 (COP1) is a well-conserved multifunctional protein in both plants and animals. Depending on the context, COP1 can have distinct roles, such as an oncogene or a tumor suppressor in mammalian cells.
Xi, Huang +6 more
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The blue light-induced interaction of cryptochrome 1 with COP1 requires SPA proteins during Arabidopsis light signaling. [PDF]
PLoS Genetics, 2017 Plants constantly adjust their growth, development and metabolism to the ambient light environment. Blue light is sensed by the Arabidopsis photoreceptors CRY1 and CRY2 which subsequently initiate light signal transduction by repressing the COP1/SPA E3 ...
Xu Holtkotte +3 more
doaj +1 more source
Photoreceptor signaling: when COP1 meets VPs [PDF]
The EMBO Journal, 2019 How structurally distinct photoreceptors regulate evolutionarily diverse transcription factors to modulate common photoresponses is an intriguing question in plant biology. In this issue of The EMBO Journal, Lau et al demonstrate that COP1, the substrate receptor of E3 ubiquitin ligase CUL4COP 1- SPA s , interacts with the diverse VP motif-containing ...
Qin Wang, Chentao Lin
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The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings [PDF]
The Plant Cell, 2014 Abstract CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) functions as an E3 ubiquitin ligase in both plants and animals. In dark-grown Arabidopsis thaliana seedlings, COP1 targets photomorphogenesis-promoting factors for degradation to repress photomorphogenesis. Little is known, however, about how COP1 itself is regulated.
Xu D +9 more
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Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice [PDF]
, 2011 Biochemical studies have suggested conflicting roles for the E3 ubiquitin ligase constitutive photomorphogenesis protein 1 (Cop 1; also known as Rfwd2) in tumorigenesis, providing evidence for both the oncoprotein c-Jun and the tumor suppressor p53 as ...
Migliorini, Domenico +10 more
core +1 more source
COP1 mutation causes low leaf temperature under various abiotic stresses in Arabidopsis thaliana
Plant Direct, 2022 Stomata are microscopic pores on epidermal cells of leaves and stems that regulate water loss and gas exchange between the plant and its environment. Constitutive photomorphogenic 1 (COP1) is an E3 ubiquitin ligase that is involved in plant growth and ...
Joo Yong Kim +5 more
doaj +1 more source
Perception of Sunflecks by the UV-B Photoreceptor UV RESISTANCE LOCUS8 [PDF]
, 2018 Sunflecks, transient patches of light that penetrate through gaps in the canopy and transiently interrupt shade, are eco-physiologically and agriculturally important sources of energy for carbon gain, but our molecular understanding of how plant organs ...
Binkert, Melanie +5 more
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Analytical Cellular Pathology, 2023 In recent years, the involvement of E3 ubiquitin ligase constitutive photomorphogenesis 1 (COP1) in the tumorigenesis of gastric cancer (GC) has been elucidated. However, the exact underlying mechanism remains to be clarified.
Benhuo Zhao +6 more
doaj +1 more source
Beyond the photocycle-how cryptochromes regulate photoresponses in plants? [PDF]
, 2018 Cryptochromes (CRYs) are blue light receptors that mediate light regulation of plant growth and development. Land plants possess various numbers of cryptochromes, CRY1 and CRY2, which serve overlapping and partially redundant functions in different plant
Gu, Lianfeng +6 more
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