Results 11 to 20 of about 12,187 (208)
Arabidopsis COP1 SUPPRESSOR 2 Represses COP1 E3 Ubiquitin Ligase Activity through Their Coiled-Coil Domains Association. [PDF]
PLoS Genetics, 2015 CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) functions as an E3 ubiquitin ligase and mediates a variety of developmental processes in Arabidopsis by targeting a number of key regulators for ubiquitination and degradation.
Dongqing Xu +8 more
doaj +5 more sources
COP1 controls salt stress tolerance by modulating sucrose content
Plant Signaling & Behavior, 2022 The E3 ubiquitin ligase Constitutive Photomorphogenic 1 (COP1) plays evolutionarily conserved and divergent roles. In plants, COP1 regulates a large number of developmental processes including photomorphogenesis, seedling emergence, and gravitropism ...
Joo Yong Kim +5 more
doaj +3 more sources
Regulation of COP1 Function by Brassinosteroid Signaling [PDF]
Frontiers in Plant Science, 2020 Small increases in temperature result in enhanced elongation of the hypocotyl and petioles and hyponastic growth, in an adaptive response directed to the cooling of the leaves and to protect the shoot meristem from the warm soil.
Cristina Nieto +2 more
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CRY arrests Cop1 to regulate circadian rhythms in mammals [PDF]
Cell Division, 2019 Cryptochromes (CRYs) are UVA and blue light photoreceptors present in all major evolutionary lineages ranging from cyanobacteria to plants and animals, including mammals. In plants, blue light activates CRYs to induce photomorphogenesis by inhibiting the
Choogon Lee
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The role of COP1 in repression of photoperiodic flowering [version 1; referees: 2 approved] [PDF]
F1000Research, 2016 Plants use the circadian clock as a timekeeping mechanism to regulate photoperiodic flowering in response to the seasonal changes. CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1), initially identified as a central repressor of seedling photomorphogenesis, was ...
Dongqing Xu, Danmeng Zhu, Xing Wang Deng
doaj +3 more sources
An Arabidopsis SUMO E3 Ligase, SIZ1, Negatively Regulates Photomorphogenesis by Promoting COP1 Activity. [PDF]
PLoS Genetics, 2016 COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1), a ubiquitin E3 ligase, is a central negative regulator of photomorphogenesis. However, how COP1 activity is regulated by post-translational modifications remains largely unknown.
Xiao-Li Lin +11 more
doaj +1 more source
Frontiers in Plant Science, 2021 CONSTITUTIVE PHOTOMORPHOGENIC 1 functions as an E3 ubiquitin ligase in plants and animals. Discovered originally in Arabidopsis thaliana, COP1 acts in a complex with SPA proteins as a central repressor of light-mediated responses in plants.
Jathish Ponnu, Ute Hoecker
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Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance COP1 is an evolutionarily conserved ubiquitin ligase that plays a critical role in regulating the growth patterns of plants in response to light. Light exposure promotes COP1 export from the nucleus, preventing COP1-mediated degradation of transcription factors that regulate light-mediated development (photomorphogenesis).
Weiming, Ouyang +5 more
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COP1 destabilizes DELLA proteins in Arabidopsis [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance DELLA proteins are plant-specific transcriptional regulators that act as signaling hubs at the interface between the environment and the transcriptional networks that control growth. The growth-promoting hormone gibberellin destabilizes DELLAs. Here we describe an alternative pathway to destabilize these proteins. We show
Noel Blanco-Touriñán +21 more
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Good COP1 or bad COP1? In vivo veritas [PDF]
Journal of Clinical Investigation, 2011 The evolutionarily conserved protein COP1 has been shown to operate as an E3 ubiquitin ligase complex, and a number of putative substrates have been identified, including the c-JUN oncoprotein and p53 tumor suppressor protein. New work by Migliorini and colleagues described in the current issue of JCI demonstrates that COP1 acts as a tumor suppressor ...
Wenyi, Wei, William G, Kaelin
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