Results 11 to 20 of about 275,056 (297)

STOP: an open label crossover trial to study ICS withdrawal in patients with a combination of obesity and low-inflammatory asthma and evaluate its effect on asthma control and quality of life

BMC Pulmonary Medicine, 2022
Background Asthma patients with obesity often have a high disease burden, despite the use of high-dose inhaled corticosteroids (ICS). In contrast to asthmatics with normal weight, the efficacy of ICS in patients with obesity and asthma is often ...
Jan A. Witte, Gert-Jan Braunstahl, Wouter J. B. Blox, Susan C. van ’t Westeinde, Johannes C. C. M. in ’t Veen, Jasper H. Kappen, Elisabeth F. C. van Rossum   +6 more
doaj   +1 more source

Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles

Respiratory Research, 2023
Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that affects 3 million people worldwide. Senescence and small extracellular vesicles (sEVs) have been implicated in the pathogenesis of IPF, although how sEVs promote disease ...
Sabha Asghar, Susan Monkley, David J. F. Smith, Richard J. Hewitt, Ken Grime, Lynne A. Murray, Catherine L. Overed-Sayer, Philip L. Molyneaux   +7 more
doaj   +1 more source

Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria

Nature Communications, 2017
Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via apoptosis mediated by calcium release from the endoplasmic reticulum (ER), but the mechanism is unclear. Here the authors show that Bik promotes Bak enrichment at the ER to tether
Yohannes A. Mebratu, Ivan Leyva-Baca, Marc G. Wathelet, Neal Lacey, Hitendra S. Chand, Augustine M. K. Choi, Yohannes Tesfaigzi   +6 more
doaj   +1 more source

Avaliação dos resultados nos ensaios clínicos na DPOC: Da função pulmonar aos marcadores biológicos

Revista Portuguesa de Pneumologia, 2008
Resumo: As sociedades científicas respiratórias europeia e americana (ERS e ATS) constituíram um grupo de trabalho sobre a “Avaliação dos resultados nos ensaios clínicos na DPOC: da função pulmonar aos marcadores biológicos” para informar a ...
M. Cazzola, W. MacNee, F.J. Martinez, K.F. Rabe   +3 more
doaj   +1 more source

Does the BCL-2 family member BIK control lung carcinogenesis?

Molecular & Cellular Oncology, 2018
Hyperplastic airway epithelial cells may be the cause for increased risk for lung cancer in patients with chronic lung diseases. The B-cell lymphoma 2 (Bcl-2) family member, Bcl-2-interacting killer (BIK), triggers cell death specifically in these ...
Yohannes A. Mebratu, Yohannes Tesfaigzi
doaj   +1 more source

Asthma Symptoms Do not Predict Spirometry

Canadian Respiratory Journal, 2007
BACKGROUND: Asthma is a disease characterized by variable airflow obstruction, but the measurement of airflow is often omitted in the process of diagnosis and management of the disease.
Robert L Cowie, Margot F Underwood, Stephen K Field   +2 more
doaj   +1 more source

COPD

TvPO
Abstract The perioperative management of patients with chronic obstructive pulmonary disease (COPD) who are currently still smoking is a challenging task for the perioperative physician. The risks for postoperative complications, increased morbidity, and mortality are high in these patients.
Wesley Rajaleelan, Jean Wong
  +8 more sources

Recent advances in the management of chronic obstructive pulmonary disease [version 1; referees: 2 approved]

F1000Research, 2017
Novel pharmacotherapies introduce additional options to providers and patients in how to best treat chronic obstructive pulmonary disease (COPD). Emerging data question the role of inhaled corticosteroids in COPD treatment, particularly as combination ...
Sharon R Rosenberg, Ravi Kalhan
doaj   +1 more source

Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF

Scientific Reports, 2021
The unfolded protein response (UPR) is a direct consequence of cellular endoplasmic reticulum (ER) stress and a key disease driving mechanism in IPF.
Susan Monkley, Catherine Overed-Sayer, Helen Parfrey, Doris Rassl, Damian Crowther, Leire Escudero-Ibarz, Nicola Davis, Alan Carruthers, Richard Berks, Marisa Coetzee, Ewa Kolosionek, Maria Karlsson, Leia R. Griffin, Maryam Clausen, Graham Belfield, Cory M. Hogaboam, Lynne A. Murray   +16 more
doaj   +1 more source

Assessment and Management of Patients with Chronic Cough by Certified Respiratory Educators: A Randomized Controlled Trial

Canadian Respiratory Journal, 2009
BACKGROUND: The value of other health care professionals is increasingly being recognized to compensate for the shortage of physicians in Canada. Chronic cough is one of the most common reasons for consultation with a respirologist. In the present study,
Stephen K Field, Diane P Conley, Amin M Thawer, Richard Leigh, Robert L Cowie   +4 more
doaj   +1 more source