Results 21 to 30 of about 74,343 (191)

CYP7A1, NPC1L1, ABCB1, and CD36 Polymorphisms Are Associated with Increased Serum Coenzyme Q₁₀ after Long-Term Supplementation in Women

Antioxidants, 2021
Coenzyme Q10 (CoQ10), an essential component for energy production that exhibits antioxidant activity, is considered a health-supporting and antiaging supplement.
Michiyo Takahashi, Mayumi Nagata, Tetsu Kinoshita, Takehiko Kaneko, Toshikazu Suzuki   +4 more
doaj   +1 more source

Manganese-driven CoQ deficiency

Nature Communications, 2022
AbstractOverexposure to manganese disrupts cellular energy metabolism across species, but the molecular mechanism underlying manganese toxicity remains enigmatic. Here, we report that excess cellular manganese selectively disrupts coenzyme Q (CoQ) biosynthesis, resulting in failure of mitochondrial bioenergetics.
Jutta Diessl, Jens Berndtsson, Filomena Broeskamp, Lukas Habernig, Verena Kohler, Carmela Vazquez-Calvo, Arpita Nandy, Carlotta Peselj, Sofia Drobysheva, Ludovic Pelosi, F.-Nora Vögtle, Fabien Pierrel, Martin Ott, Sabrina Büttner   +13 more
openaire   +6 more sources

Experience Implementing a Performant Category-Theory Library in Coq [PDF]

, 2014
We describe our experience implementing a broad category-theory library in Coq. Category theory and computational performance are not usually mentioned in the same breath, but we have needed substantial engineering effort to teach Coq to cope with large ...
A. Miquel, B. Barras, B. Spitters, F. Garillot, G. O’Keefe   +4 more
core   +5 more sources

Metabolism of the Flavonol Kaempferol in Kidney Cells Liberates the B-ring to Enter Coenzyme Q Biosynthesis

Molecules, 2020
Coenzyme Q (CoQ) is an essential component of the mitochondrial electron transport chain and an important antioxidant present in all cellular membranes.
Lucía Fernández-del-Río, Eric Soubeyrand, Gilles J. Basset, Catherine F. Clarke   +3 more
doaj   +1 more source

Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q

Redox Biology, 2021
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a range of
Anita Ayer, Daniel J. Fazakerley, Cacang Suarna, Ghassan J. Maghzal, Diba Sheipouri, Kevin J. Lee, Michelle C. Bradley, Lucía Fernández-del-Rio, Sergey Tumanov, Stephanie MY. Kong, Jelske N. van der Veen, Andrian Yang, Joshua W.K. Ho, Steven G. Clarke, David E. James, Ian W. Dawes, Dennis E. Vance, Catherine F. Clarke, René L. Jacobs, Roland Stocker   +19 more
doaj   +1 more source

A propos du programme de maturité fédérale en géographie [PDF]

Geographica Helvetica
No abstract available.
J. Portmann
doaj   +1 more source

La Suède/Kiruna [PDF]

Geographica Helvetica
No abstract available.
J. Portmann
doaj   +1 more source

CoQ₁₀Phytosomes Improve Cellular Ubiquinone Uptake in Skeletal Muscle Cells: An Ex Vivo Study Using CoQ₁₀-Enriched Low-Density Lipoproteins Obtained in a Randomized Crossover Study

Antioxidants, 2023
Coenzyme Q10 (CoQ10) bioavailability in vivo is limited due to its lipophilic nature. Moreover, a large body of evidence in the literature shows that muscle CoQ10 uptake is limited. In order to address cell specific differences in CoQ uptake, we compared
Fabio Marcheggiani, Patrick Orlando, Sonia Silvestri, Ilenia Cirilli, Antonella Riva, Giovanna Petrangolini, Francesca Orsini, Luca Tiano   +7 more
doaj   +1 more source

How plants synthesize coenzyme Q

Plant Communications, 2022
Coenzyme Q (CoQ) is a conserved redox-active lipid that has a wide distribution across the domains of life. CoQ plays a key role in the oxidative electron transfer chain and serves as a crucial antioxidant in cellular membranes.
Jing-Jing Xu, Mei Hu, Lei Yang, Xiao-Ya Chen   +3 more
doaj   +1 more source

L-Carnosine Stimulation of Coenzyme Q10 Biosynthesis Promotes Improved Mitochondrial Function and Decreases Hepatic Steatosis in Diabetic Conditions

Antioxidants, 2021
Mitochondrial dysfunction in type 2 diabetes leads to oxidative stress, which drives disease progression and diabetes complications. L-carnosine, an endogenous dipeptide, improves metabolic control, wound healing and kidney function in animal models of ...
Cheng Schwank-Xu, Elisabete Forsberg, Magnus Bentinger, Allan Zhao, Ishrath Ansurudeen, Gustav Dallner, Sergiu-Bogdan Catrina, Kerstin Brismar, Michael Tekle   +8 more
doaj   +1 more source