Results 141 to 150 of about 470,683 (177)

Targeting ferroptosis in cancer: molecular mechanisms and emerging therapeutic strategies. [PDF]

Biochem Biophys Rep
Khaledi M, Ahani H, Rezaei Tohid F, Kazemi F, Amirkhani E, Daliri Z, Yadegari S, Moarefvand K, Poureslamfar B, Sameni F, Yazdansetad S.   +10 more
europepmc   +1 more source

Ferroptosis in cancer: molecular mechanisms, tumour microenvironment, therapeutic resistance, and clinical translation. [PDF]

J Egypt Natl Canc Inst
Dewasi G, Jain S.
europepmc   +1 more source

RTN4IP1 is required for the final stages of mitochondrial complex I assembly and CoQ biosynthesis. [PDF]

EMBO J
Oláhová M, Guerra RM, Collier JJ, Heidler J, Thompson K, White CR, Castañeda-Tamez P, Cabrera-Orefice A, Lightowlers RN, Chrzanowska-Lightowlers ZMA, Galkin A, Wittig I, Pagliarini DJ, Taylor RW.   +13 more
europepmc   +1 more source

Coenzyme Q10 Supplementation in a Child with Biallelic <i>COQ8A</i> Variants: A Case Report. [PDF]

Case Rep Neurol
Motoi H, Watanabe R, Shirai A, Sakata Y, Kuroda Y, Watanabe Y, Ito S.   +6 more
europepmc   +1 more source

Analysis of Coenzyme Q10 in Muscle and Fibroblasts for the Diagnosis of CoQ10 Deficiency Syndromes [PDF]

Clinical Biochemistry, 2008
OBJECTIVES: To study CoQ(10) concentrations in muscle and fibroblast from 6 patients with a CoQ(10) deficiency syndrome. DESIGN AND METHODS: CoQ(10) was quantified by HPLC with electrochemical detection.
Leonardo Salviati, José A Sánchez-Alcázar, Rafael Artuch   +2 more
exaly   +3 more sources

Ubiquinol-10 Ameliorates Mitochondrial Encephalopathy Associated With CoQ Deficiency

Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2014
Coenzyme Q10 (CoQ10) deficiency (MIM 607426) causes a mitochondrial syndrome with variability in the clinical presentations. Patients with CoQ10 deficiency show inconsistent responses to oral ubiquinone-10 supplementation, with the highest percentage of unsuccessful results in patients with neurological symptoms (encephalopathy, cerebellar ataxia or ...
Laura García-Corzo, Marisol Fernandez-Ortiz, Carolina Doerrier   +2 more
exaly   +5 more sources

Mechanisms and Therapeutic Effects of Benzoquinone Ring Analogs in Primary CoQ Deficiencies

Antioxidants, 2022
Coenzyme Q (CoQ) is a conserved polyprenylated lipid composed of a redox-active benzoquinone ring and a long polyisoprenyl tail that serves as a membrane anchor. CoQ biosynthesis involves multiple steps, including multiple modifications of the precursor ring 4-hydroxybenzoic acid.
Agustin Hidalgo-Gutierrez, Catarina M Quinzii   +1 more
exaly   +4 more sources

CoQ Deficiency Causes Disruption of Mitochondrial Sulfide Oxidation, a New Pathomechanism Associated With This Syndrome [PDF]

EMBO Molecular Medicine, 2017
Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain, but it also has several other functions in the cellular metabolism. One of them is to function as an electron carrier in the reaction catalyzed by sulfide:quinone oxidoreductase (
Agustin Hidalgo-Gutierrez, Eliana Barriocanal-Casado, Tatjana M Hildebrandt   +2 more
exaly   +2 more sources