Results 31 to 40 of about 9,908 (255)
Separations, 2022 Cordycepin (3′-deoxyadenosine) is a potent bioactive metabolite of the medicinal fungus Cordyceps militaris, which has been increasingly exploited to treat various chronic diseases in humans.
Nguyen Van Quan +4 more
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Synthesis of 4′-substituted cordycepins [PDF]
Nucleic Acids Symposium Series, 2005 Synthesis of 4'-substituted analogues of cordycepin was carried out. Electrophilic addition of N-iodosuccinimide/benzoic acid to 2',5'-bis-O-(tert-butyldimethyl-silyl)-3',4'-unsaturated adenosine (5) enabled the introduction of a leaving group to the 4'-position.
Yutaka, Kubota +5 more
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Pharmaceutics, 2022 Benign prostatic hyperplasia (BPH) is a disease that commonly affects elderly men. Cordycepin is an adenosine analog with a wide range of pharmacological activities including antiproliferative and prostatic smooth muscle relaxant effects.
Abdulmohsin J. Alamoudi +8 more
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Frontiers in Microbiology, 2020 Cordycepin, isolated from the traditional medicinal fungus Cordyceps militaris, has gained much attention due to its various clinical functions. Previous reports of L-alanine addition could significantly improve cordycepin production, but the molecular ...
Bai-Xiong Chen +18 more
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Studies on the biosynthesis of cordycepin [PDF]
Biochimica et Biophysica Acta, 1961 The carboxyl carbons of acetate and isovalerate do not serve to any appreciable extent as precursors of cordycepin, thus arguing against the origin of cordycepose from pathways of isoprenoid biosynthesis. Exogenously added [8-14C]adenine, [I-14C]-glucose, and [6-14C]glucose serve as excellent precursors, the latter two compounds labeling both the base ...
Kredich, Nicholas M., Guarino, Armand J.
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Antifungal Activity of 3′-Deoxyadenosine (Cordycepin) [PDF]
Antimicrobial Agents and Chemotherapy, 1998 ABSTRACT The antifungal activity of the nucleoside analog 3′-deoxyadenosine (cordycepin) was studied in a murine model of invasive candidiasis. When protected from deamination by either deoxycoformycin or coformycin, both of which are adenosine deaminase inhibitors, cordycepin exhibited potent antifungal efficacy, as demonstrated
A M, Sugar, R P, McCaffrey
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Blockade of adipocyte differentiation by cordycepin [PDF]
British Journal of Pharmacology, 2012 BACKGROUND AND PURPOSE Cordyceps militaris has the potential to suppress differentiation of pre‐adipocytes. However, the active entities in the extract and the underlying mechanisms of its action are not known. Hence, we investigated whether and how cordycepin (3′‐deoxyadenosine), a constituent of C.
Shuhei, Takahashi +6 more
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Effection of cordycepin on Inhibition proliferation by activating autophagy in HepG2 cell [PDF]
E3S Web of Conferences, 2020 Cordycepin, the main active component of Cordyceps militaris, possesses a variety of biological activities. This paper investigated the inhibition of cordycepin on liver tumors. HepG2 cells were treated with cordycepin.
Tianjiao Li, Bijun Cheng, Fenglin Li
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Protective effects of cordycepin pretreatment against liver ischemia/reperfusion injury in mice
Immunity, Inflammation and Disease, 2023 Introduction Cordycepin has been reported to exhibit hepatic protective and anti‐inflammatory properties. Here, we investigated the role of cordycepin in ischemia/reperfusion (IR)‐induced liver injury in a mouse model.
Yunxia Liu +4 more
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Journal of Dental Sciences, 2022 Background/purpose: Cordycepin has been proposed anti-cancer effects, however, it is unclear whether and how cordycepin affects oral squamous carcinoma cell (OSCC) migration and invasion.
Thunwa Binlateh +6 more
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