Results 81 to 90 of about 5,838 (160)

Patients with IgG1-anti-red blood cell autoantibodies show aberrant Fc-glycosylation

Scientific Reports, 2017
Autoimmune hemolytic anemia (AIHA) is a potentially severe disease in which red blood cells (RBC) are destroyed by IgG anti-RBC autoantibodies which can lead to hemolysis. We recently found IgG Fc-glycosylation towards platelet and RBC alloantigens to be
Myrthe E. Sonneveld, Masja de Haas, Carolien Koeleman, Noortje de Haan, Sacha S. Zeerleder, Peter C. Ligthart, Manfred Wuhrer, C. Ellen van der Schoot, Gestur Vidarsson   +8 more
doaj   +1 more source

Chemoenzymatic Labeling, Detection and Profiling of Core Fucosylation in Live Cells

Journal of the American Chemical Society
Core fucosylation, the attachment of an α-1,6-linked-fucose to the N-glycan core pentasaccharide, is an abundant protein modification that plays critical roles in various biological processes such as cell signaling, B cell development, antibody-dependent cellular cytotoxicity, and oncogenesis.
Qiang Zhu, Jean-Luc Chaubard, Didi Geng, Jiechen Shen, Lan Ban, Sheldon T. Cheung, Fangyu Wei, Yating Liu, Haofan Sun, Angie Calderon, Wenbo Dong, Weijie Qin, Tiehai Li, Liuqing Wen, Peng George Wang, Shisheng Sun, Wen Yi, Linda C. Hsieh-Wilson   +17 more
openaire   +3 more sources

Core fucosylation of IL-2RB is required for natural killer cell homeostasis

Cell Reports
Summary: Natural killer (NK) cell homeostasis and effector functions require context-dependent signaling via numerous receptors, including the interleukin-15 receptor (IL-15R).
Harrison Sudholz, Xiangpeng Meng, Hae-Young Park, Zihan Shen, Iva Nikolic, Joseph Cursons, Ethan D. Goddard-Borger, Iona S. Schuster, Christopher E. Andoniou, Mariapia A. Degli-Esposti, Nichollas E. Scott, Michael Chopin, Jai Rautela, Sebastian Scheer, Nicholas D. Huntington   +14 more
doaj   +1 more source

Therapy-induced remodeling of IgG and plasma N-glycans in breast cancer

BMC Cancer
Background Protein N-glycosylation plays a key role in cancer biology and may offer insights into tumor behavior and treatment response. This study investigated changes in N-glycosylation of immunoglobulin G (IgG) and total plasma proteins in patients ...
Martina Maričić Vrban, Barbara Radovani Trbojević, David Visentin, Katarina Ramljak, Iva Kirac, Mihaela Gaće, Ivan Milas, Gordan Lauc, Dragan Primorac, Ivan Gudelj   +9 more
doaj   +1 more source

A high-resolution N-glycoproteome landscape of aging mouse ovary

Redox Biology
Ovarian aging typically precedes the decline of other organ systems, yet its molecular mechanisms remain poorly understood. Glycosylation as one of the most important protein modifications has been especially unexplored in this context.
Yongqi Wu, Zhida Zhang, Yongchao Xu, Yingjie Zhang, Lin Chen, Yiwen Zhang, Ke Hou, Muyao Yang, Zhehui Jin, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
doaj   +1 more source

FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension. [PDF]

Aging Dis, 2023
Zhang W, Lin W, Zeng X, Zhang M, Chen Q, Tang Y, Sun J, Liang B, Zha L, Yu Z.   +9 more
europepmc   +1 more source

A “One-Step” Strategy for the Global Characterization of Core-Fucosylated Glycoproteome

JACS Au
Core fucosylation, a special type of N-linked glycosylation, is important in tumor proliferation, invasion, metastatic potential, and therapy resistance. However, the core-fucosylated glycoproteome has not been extensively profiled due to the low abundance and poor ionization efficiency of glycosylated peptides.
Yuqiu Wang, Rui Yuan, Bo Liang, Jing Zhang, Qin Wen, Hongxu Chen, Yinping Tian, Liuqing Wen, Hu Zhou   +8 more
openaire   +3 more sources

Retracted: Glycyrrhizic Acid Inhibits Core Fucosylation Modification Modulated EMT and Attenuates Bleomycin-Induced Pulmonary Fibrosis. [PDF]

Evid Based Complement Alternat Med, 2023
And Alternative Medicine EC.
europepmc   +1 more source

The role of FUT8-catalyzed core fucosylation in Alzheimer's amyloid-β oligomer-induced activation of human microglia. [PDF]

Glia, 2023
Jin LW, di Lucente J, Ruiz Mendiola U, Tang X, Zivkovic AM, Lebrilla CB, Maezawa I.   +6 more
europepmc   +1 more source

Anastrozole and Tamoxifen Impact on IgG Glycome Composition Dynamics in Luminal A and Luminal B Breast Cancers

Antibodies
This study examines the intricate relationship between protein glycosylation dynamics and therapeutic responses in Luminal A and Luminal B breast cancer subtypes, focusing on anastrozole and tamoxifen impacts. The present methods inadequately monitor and
Borna Rapčan, Matko Fančović, Tea Pribić, Iva Kirac, Mihaela Gaće, Frano Vučković, Gordan Lauc   +6 more
doaj   +1 more source