Results 51 to 60 of about 683,800 (267)

Capturing the Heterogeneity of the PDAC Tumor Microenvironment: Novel Triple Co-Culture Spheroids for Drug Screening and Angiogenic Evaluation

Cells
Pancreatic ductal adenocarcinoma (PDAC) presents significant treatment challenges due to its desmoplastic reaction, which impedes therapeutic effectiveness, highlighting the need for advanced vitro models to better mimic the complex tumor environment ...
Ruben Verloy, Angela Privat-Maldonado, Jonas Van Audenaerde, Sophie Rovers, Hannah Zaryouh, Jorrit De Waele, Delphine Quatannens, Dieter Peeters, Geert Roeyen, Christophe Deben, Evelien Smits, Annemie Bogaerts   +11 more
doaj   +1 more source

Incidence and outcomes of critical illness in Indigenous Peoples: a systematic review protocol

Systematic Reviews, 2022
Background Indigenous Peoples experience health inequities across the continuum of health services. Improvements for Indigenous patients and their families during vulnerable experiences with the healthcare system may have a significant impact on the ...
Samantha L. Bowker, Kienan Williams, Aireen Wingert, Jamie M. Boyd, Melissa L. Potestio, Michelle Gates, Erica Wright, Sean M. Bagshaw   +7 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

AI-enabled 5G energy-saving technology

Dianxin kexue, 2021
With the development of 5G commercialization, the number of 5G wireless base station sites has increased sharply, 5G core networks need to be deployed in regions/provinces/cities data centers, as well as the data centers were developing on a larger scale,
Dan XU, Yu ZENG, Weiye MENG, Lika LI
doaj  

Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study

Alzheimer’s Research & Therapy, 2022
Background Chronic inflammation is a central feature of several forms of dementia. However, few details on the associations of blood-based inflammation-related proteins with dementia incidence have been explored yet.
Kira Trares, Megha Bhardwaj, Laura Perna, Hannah Stocker, Agnese Petrera, Stefanie M. Hauck, Konrad Beyreuther, Hermann Brenner, Ben Schöttker   +8 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Development and validation of the Normalized Organoid Growth Rate (NOGR) metric in brightfield imaging-based assays

Communications Biology
This study focuses on refining growth-rate-based drug response metrics for patient-derived tumor organoid screening using brightfield live-cell imaging.
Christophe Deben, Edgar Cardenas De La Hoz, Felicia Rodrigues Fortes, Maxim Le Compte, Sofie Seghers, Steve Vanlanduit, Hendrik Vercammen, Bert Van Den Bogert, Nelson Dusetti, Abraham Lin, Geert Roeyen, Marc Peeters, Hans Prenen, Filip Lardon, Evelien Smits   +14 more
doaj   +1 more source

Integration of LTE 230 and LTE 1800 in Power Wireless Private Networks

Future Internet, 2019
Power wireless private networks (PWPNs) have been highly developed in China in recent years. They provide a basis for the energy Internet of Things, which enables the exchange of energy information between devices.
Zhengyang Ding, Weiwei Miao, Mingxuan Zhang, Wei Li, Rui Liu, Jun Zou, Chen Xu   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source