Results 51 to 60 of about 1,591 (162)

Investigating the Chemical, Antifungal, and Cytotoxic Properties of Cochlospermum vitifolium Leaves and Stem Bark Extracts

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
This figure contains images created by Freepik from Flaticon. ABSTRACT Comprehensive analysis of the chemical properties and bioactivities of plant extracts is essential for identifying compounds with therapeutic potential. This study analyzed hydroethanolic extracts from the leaves and stem bark of Cochlospermum vitifolium, investigating their ...
Francisco A. S. D. Pinheiro, Addison R. Almeida, Matheus S. Menezes, Thomaz Rocha, Weslley S. Paiva, Hugo A. O. Rocha, Cristiane F. de Assis, Gislene Ganade, Laila S. Espindola, Leandro S. Ferreira   +9 more
wiley   +1 more source

Apoptotic and genomic effects of corilagin on SKOV3 ovarian cancer cell line

OncoTargets and Therapy, 2017
Corilagin is a member of the tannin family and has been isolated from traditional Chinese medicinal plants, such as Phyllanthus spp. Corilagin has anti-inflammatory, antioxidative, antiatherogenic, and antihypertensive effects in various experimental models.
Rukset Attar, Zeynep Birsu Cincin, Elif Sinem Bireller, Bedia Cakmakoglu   +3 more
openaire   +5 more sources

Corilagin ameliorates the extreme inflammatory status in sepsis through TLR4 signaling pathways [PDF]

BMC Complementary and Alternative Medicine, 2017
Sepsis is one of the serious disorders in clinical practice. Recent studies found toll-like receptors 4 (TLR4) played an important role in sepsis. In this study, we tried to find the influence of Corilagin on TLR4 signal pathways in vitro and in vivo.The cellular and animal models of sepsis were established by LPS and then interfered with Corilagin ...
Li, Hua-Rong, Liu, Jie, Zhang, Shu-Ling, Luo, Tao, Wu, Fei, Dong, Ji-Hua, Guo, Yuan-Jin, Zhao, Lei   +7 more
openaire   +2 more sources

The Effects and Mechanisms of Pomegranate on Regulating Lipid Metabolism

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This study established a high‐fat diet‐induced hyperlipidemia rat model to investigate the lipid‐lowering effects of pomegranate. Pomegranate intervention significantly reduced serum total cholesterol (TC), triglyceride (TG), and low‐density lipoprotein cholesterol (LDL‐C) levels, while alleviating hepatic steatosis by decreasing liver weight and fat ...
Hao Wang, Jingtao Liu, Xin Dong, Tiantian Shi, Xuena Zhang, Yide He, Shaonan Hu, Yuewu Wang, Jian Zheng, Peifeng Xue   +9 more
wiley   +1 more source

Molecular Dynamics Simulation of Bioactive Compounds Against Six Protein Target of Sars-Cov-2 As Covid-19 Antivirus Candidates

Jurnal Kimia Valensi, 2021
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus that causes Coronavirus 2019 (COVID-19). To date, there has been no proven effective drug for the treatment or prevention of COVID-19.
Fikry Awaluddin, Irmanida Batubara, Setyanto Tri Wahyudi   +2 more
doaj   +1 more source

Are Tetrapleura tetraptera Phytochemicals Druggable Against SARS‐CoV‐2 Papain‐Like Protein? A Computational Approach

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
SARS‐CoV2 Omicron and its substrains are still a critical global health issue and extremely contagious, even with widespread vaccination efforts. Hospitalizations and mortality rates linked to these variants are still prevalent. Current therapeutic options face challenges, including low effectiveness, suboptimal pharmacokinetics, and drug resistance ...
Frank Eric Tatsing Foka, Hazel Tumelo Mufhandu   +1 more
wiley   +1 more source

Corilagin enhances the anti-tumor activity of 5-FU by downregulating the expression of GRP 78

Scientific Reports, 2023
Colorectal cancer is one of the most common malignancies worldwide. Although initially effective, patients who receive chemotherapy ultimately experience various complications and develop chemo-resistance, leading to cancer recurrence.
Simin Li, Xinquan Li, Xiliang Yang, Yumeng Lei, Mingxin He, Xiaochen Xiang, Qingming Wu, Hongyun Liu, Jiadun Wang, Qiang Wang   +9 more
doaj   +1 more source

ALDH2 Mediated Ferroptosis Regulation in Ischemia–Reperfusion Injury

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT Ischemia–reperfusion injury (IRI) is a common complication in diverse clinical settings, including myocardial infarction, stroke, organ transplantation and major surgery. Its pathological core lies in the metabolic disruption caused by blood flow cessation, followed by oxidative stress, inflammatory cascades and cell death upon reperfusion ...
Liang Han, Wen Zhai
wiley   +1 more source

Corilagin alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation via the Olfr2 signaling pathway in vitro and in vivo

Frontiers in Immunology
IntroductionAtherosclerosis, a leading cause of global cardiovascular mortality, is characterized by chronic inflammation. Central to this process is the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome, which significantly influences ...
Jinqian Mao, Yunfei Chen, Qiushuo Zong, Cuiling Liu, Jiao Xie, Yujie Wang, David Fisher, Nguyen Thi Thu Hien, Khrystyna Pronyuk, Erkin Musabaev, Yiqing Li, Lei Zhao, Yiping Dang   +12 more
doaj   +1 more source

Activity of Corilagin on Post-Parasiticide Liver Fibrosis in Schistosomiasis Animal Model

International Journal of Immunopathology and Pharmacology, 2013
This study investigates the effects and possible molecular mechanisms of corilagin extraction on prevention of Schistosoma japonicum ova-induced granulomas and liver fibrosis. As a result, under a light microscope, when compared to a model group, the corilagin group showed smaller granulomas, less liver cell denaturation and less inflammatory cell ...
Y-F, Huang, S-L, Zhang, F, Jin, D, Cheng, Y-P, Zhou, H-R, Li, Z-M, Tang, J, Xue, W, Cai, J-H, Dong, L, Zhao   +10 more
openaire   +2 more sources