Results 21 to 30 of about 184,263 (263)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Functional annotation and meta-analysis of maize transcriptomes reveal genes involved in biotic and abiotic stress

BMC Genomics
Background Environmental stress factors, such as biotic and abiotic stress, are becoming more common due to climate variability, significantly affecting global maize yield.
Rita K Hayford, Olivia C Haley, Ethalinda K Cannon, John L Portwood, Jack M Gardiner, Carson M Andorf, Margaret R Woodhouse   +6 more
doaj   +1 more source

Identification and comparative analysis of Identification and comparative analysis of microRNA in wheat (Triticum aestivum L.) callus derived from mature and immature embryos during in vitro culture

Frontiers in Plant Science, 2016
Feasible and efficient tissue culture plays an important role in plant genetic engineering. Wheat (Triticum aestivum L.) immature embryos (IMEs) are preferred for tissue culture to mature embryos (MEs) because IMEs easily generate embryogenic callus ...
Chu Zong Li, Chu Zong Li, Chu Zong Li, Chen Jun ying, Chen Jun ying, Chen Jun ying, Xu Hai Xia, Xu Hai Xia, Xu Hai Xia, Dong Zhong Dong, Dong Zhong Dong, Dong Zhong Dong, Chen Feng, Chen Feng, Chen Feng, Cui Dang Qun, Cui Dang Qun, Cui Dang Qun   +17 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Influence of Abiotic Stresses on Morphophysiological Characteristics and Biological Value of Grain Sorghum bicolor (L.) Moench

International Journal of Plant Biology, 2023
Sorghum is the agricultural crop most adaptable to the effects of abiotic factors, able to tolerate prolonged soil and air droughts, changes in air temperature, insufficient precipitation, salinization, acidification of soils, and many others with the ...
Oksana Pavlovna Kibalnik, Irina Alexandrovna Sazonova, Yulia Valerievna Bochkareva, Vera Valerievna Bychkova, Dmitry Sergeevich Semin   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Mapping Quantitative Trait Loci Associated With Resistance to Aflatoxin Accumulation in Maize Inbred Mp719

Frontiers in Microbiology, 2020
Aflatoxins are carcinogenic and toxic compounds produced principally by fungal species Aspergillus flavus (Link: Fries) and A. parasiticus (Speare), which are common contaminants of food and feed.
Erika D. Womack, W. Paul Williams, Gary L. Windham, Wenwei Xu, Wenwei Xu   +4 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Climate change and amphibians

Animal Biodiversity and Conservation, 2007
Cambio climático y anfibios Las historias vitales de los anfibios son sumamente sensibles a la temperatura y a la precipitación, y hay una clara evidencia que el reciente cambio climático ha tenido como resultado para algunas especies una anticipación ...
P. S. Corn
doaj   +3 more sources

Ascorbic acid is involved in melatonin-induced salinity tolerance of maize (Zea mays L.) by regulating antioxidant and photosynthetic capacities

Photosynthetica
Melatonin (MT), an indole compound, can boost plant growth under abiotic stress conditions. This experiment aims to elucidate the synergistic effect of MT and ascorbic acid (AsA) in mitigating salinity stress by assessing the photosynthetic and ...
M. ZHU, T. GUO, Y.B. LIU, R. XIAO, T. YU, J.X. HUANG, W.L. DU, X.M. ZHONG, B. SONG, F.H. LI   +9 more
doaj   +1 more source