Results 61 to 70 of about 5,519,513 (263)

Mechanotransductive Differentiation of Hair Follicle Stem Cells Derived from Aged Eyelid Skin into Corneal Endothelial-Like Cells

, 2022
Corneal endothelial insufficiency is one of the leading causes of blindness. The main contemporary treatment for corneal blindness is endothelial keratoplasty, which, however, is unsatisfactory as a medical therapy due to the lack of donor corneas and ...
Olszewski, Christian, Maassen, Jessika, Guenther, Rebecca, Gutermuth, Angela, Skazik-Voogt, Claudia   +4 more
core   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Corneal thickness, endothelial cell density, and morphological and morphometric features of corneal endothelial cells in goats

American Journal of Veterinary Research, 2018
Abstract OBJECTIVE To determine corneal thickness (CT), endothelial cell density (ECD), and morphological and morphometric features of caprine eyes and to assess effects of aging on these variables. SAMPLE 27 healthy eyes of 19 Murciano-Granadina goats.
Natalia, Coyo, Marta, Leiva, Daniel, Costa, José, Rios, Teresa, Peña   +4 more
openaire   +2 more sources

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Heterologous corneal endothelial cell transplantation: human corneal endothelial cell transplantation in Lewis rats [PDF]

Journal of Korean Medical Science, 1992
A heterologous corneal endothelial transplantation was attempted using human endothelial cells and a Lewis rat penetrating keratoplasty model. Cultured human endothelial cells were seeded to a Lewis rat cornea, which was denuded of its endothelium. When grafted into the syngeneic Lewis rat, the graft remained clear for at least five days, and then ...
openaire   +2 more sources

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Corneal endothelial morphology in patients with herpetic keratitis attending tertiary eye centre

BMC Ophthalmology
Background Herpetic keratitis is a common cause of infectious corneal disease and can result in long term visual morbidity. While its effects on the corneal epithelium and stroma are well recognized, its impact on the corneal endothelium remains less ...
Barsha Kumari Singh, Sanjeeta Sitaula, Sanjeev Bhattarai, Niraj Dev Joshi, Prakash Jha   +4 more
doaj   +1 more source

Long-Term Observation and Sequencing Analysis of SKPs-Derived Corneal Endothelial Cell-Like Cells for Treating Corneal Endothelial Dysfunction

Cell Transplantation, 2021
Corneal endothelial dysfunction is a principal cause of visual deficiency. Corneal transplantation is the most effective treatment for corneal endothelial dysfunction.
Lin Shen, Peng Sun, Liqun Du, Jing Zhu, Chengqun Ju, Hui Guo, Xinyi Wu   +6 more
doaj   +1 more source

Corneal Endothelial Cell Proliferation: A Function of Cell Density [PDF]

Investigative Ophthalmology & Visual Science, 2009
To determine how stimuli that increase corneal endothelial cell proliferation of human corneas in culture relate to changes in endothelial cell density in the central and peripheral cornea.Human donor cadaver corneas not suitable for transplantation were divided into four pie-shaped wedges and incubated at 37 degrees C in medium supplemented with fetal
Sangita P, Patel, William M, Bourne
openaire   +2 more sources

Corneal Endothelial Cell Count (/mm², mean±SD).

, 2014
Corneal Endothelial Cell Count (/mm2, mean±SD).
Xiaoning Li (581082), Feng Zhao (90241), Jing Luo (146659), Daping Quan (581083), Tao Wang (12008), Ji Liu (110659), Lei Xi (315333), Qiongjuan Zheng (581081), Jian Ge (49951)   +8 more
core   +1 more source