Results 61 to 70 of about 959,050 (193)

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice [PDF]

, 2010
Excessive production of reactive oxygen species (ROS) contributes to progression of atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory activation. The class III histone deacetylase SIRT1 has been implicated in extension
Handschin, C, Heinrich, Kathrin, Schäfer, N, Heinrich, K, Winnik, Stephan, Matter, Christian M., Brokopp, Chad E., Tanner, F C, Tanner, Felix C., Landmesser, Ulf, Breitenstein, A, Handschin, Christoph, Stein, Sokrates, Landmesser, U, Lüscher, Thomas F., Breitenstein, Alexander, Schäfer, Nicola, Besler, C, Winnik, S, Lohmann, C, Lüscher, T F, Lohmann, Christine, Besler, Christian, Matter, C M, Brokopp, C E, Stein, S, Landmesser U, Stein S, Lüscher TF, Besler C, Tanner FC, Breitenstein A, Lohmann C, Heinrich K, Matter CM, Winnik S, Brokopp CE, Handschin C, Schäfer N   +38 more
core   +1 more source

Image_1_Extracellular Vesicles Derived From Human Corneal Endothelial Cells Inhibit Proliferation of Human Corneal Endothelial Cells.TIF

, 2022
Corneal endothelial cells (CEnCs) are a monolayer of hexagonal cells that are responsible for maintaining the function and transparency of the cornea. Damage or dysfunction of CEnCs could lead to blindness.
Mohit Parekh (6643547), Sajjad Ahmad (768814), Hefin Rhys (9551069), Tiago Ramos (817043), Stefano Ferrari (224700)   +4 more
core   +1 more source

Fabrication of bioengineered corneal endothelial grafts using an allogeneic cornea-derived matrix

Materials Today Bio
Corneal endothelial keratoplasty has been the primary treatment method of endothelial decompensation, but it is often limited in clinical practice due to global shortage of donor cornea.
Lijie Xie, Xiaojuan Dong, Jianping Ji, Chen Ouyang, Jing Wu, Chao Hou, Ting Huang   +6 more
doaj   +1 more source

Mitochondrial ROS in Slc4a11 KO Corneal Endothelial Cells Lead to ER Stress

Frontiers in Cell and Developmental Biology, 2022
Recent studies from Slc4a11−/− mice have identified glutamine-induced mitochondrial dysfunction as a significant contributor toward oxidative stress, impaired lysosomal function, aberrant autophagy, and cell death in this Congenital Hereditary ...
Rajalekshmy Shyam, Diego G. Ogando, Joseph A. Bonanno   +2 more
doaj   +1 more source

Artificial Intelligence in Ophthalmology: From Methodological Advances to Clinical Translation and Future Directions

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is reshaping ophthalmology from task‐specific image analysis toward multimodal, longitudinal, and clinically integrated decision support. This narrative review summarizes the methodological evolution of ophthalmic AI, including traditional machine learning, task‐specific deep learning, self‐supervised learning ...
Yuxin Liu, Hanruo Liu
wiley   +1 more source

Corneal endothelial cell morphometry and corneal thickness in diabetic contact lens wearers

, 2004
Purpose. To assess corneal endothelial cell morphometry and corneal thickness in diabetic patients who wear contact lenses. Methods. Images of the central corneal endothelium were analyzed quantitatively and qualitatively and corneal thickness was ...
NATHAN EFRON, CLARE O???DONNELL, Efron, Nathan, O'Donnell, Clare   +3 more
core   +1 more source

A novel single-cell level evaluation method for corneal endothelial cell function

npj Digital Medicine
Approximately 10 million people worldwide suffer from corneal diseases, with endothelial dysfunction being a leading cause of blindness. Current morphological assessments lack sensitivity for detecting early corneal endothelial abnormalities.
Dongfang Li, Zongyi Li, Haoyun Duan, Xinhang Wang, Zhan Lin, Kun Dai, Quan Qi, Yanling Dong, Ping Lin, Wenjie Su, Shuting Wang, Xiangyue Hu, Xiaojing Pan, Xiaomin Liu, Qingjun Zhou, Lixin Xie   +15 more
doaj   +1 more source

Protective effects of adiponectin receptor agonists against equine lamellar endoplasmic reticulum stress

Equine Veterinary Journal, EarlyView.
Abstract Background Lamellar endoplasmic reticulum (ER) stress occurs in hyperinsulinemia‐associated and sepsis‐related laminitis. Adiponectin is associated with reduced laminitis risk and inhibits ER stress in other species. Objectives To induce ER stress in ex vivo equine lamellar cells using pharmacological agents.
Marine A. Barnabé, Jonathan Elliott, Nicola J. Menzies‐Gow, Simon R. Bailey, Nicholas J. Bamford, Yu‐Mei Chang, Matthew C. Gage   +6 more
wiley   +1 more source