Results 51 to 60 of about 1,009,765 (207)

Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease

Journal of the American College of Cardiology, 2001
We aimed to determine whether intracoronary supplementation with nitric oxide (NO) synthase co-factor tetrahydrobiopterin (BH4) improves NO-dependent coronary microvascular dilation in patients with coronary risk factors but no significant organic stenosis.Impaired coronary microvascular dilator reserve attributable to endothelial dysfunction plays an ...
Setoguchi, Soko, Mohri, Masahiro, Shimokawa, Hiroaki, Takeshita, Akira   +3 more
openaire   +2 more sources

Cell therapy rescues aging-induced beta-1 adrenergic receptor and GRK2 dysfunction in the coronary microcirculation

GeroScience, 2021
Our past study showed that coronary arterioles isolated from adipose-derived stromal vascular fraction (SVF)-treated rats showed amelioration of the age-related decrease in vasodilation to beta-adrenergic receptor (β-AR) agonist and improved β-AR-dependent coronary flow and microvascular function in a model of advanced age.
Gabrielle Rowe, Evan Tracy, Jason E. Beare, Amanda J. LeBlanc   +3 more
openaire   +3 more sources

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

Advances in Coronary Microvascular Dysfunction

, 2009
Considerable focus has been directed towards coronary arterial disease in the management of coronary heart disease, however the coronary microcirculation plays a major role in the regulation of coronary blood flow. Thus while we have multiple medical and
Beltrame, J., Camici, P., Crea, F.
core   +1 more source

Coronary Endothelial Dysfunction and Impaired Microcirculation Response to Atrial Natriuretic Peptide in Hyperinsulinemia

Journal of Cardiovascular Pharmacology and Therapeutics, 2008
Endothelial dysfunction occurs in hyperinsulinemia (HI). Coronary microcirculation responses to vasoactive agents are examined in 57 patients with angiographically normal coronary arteries. Patients were divided into 2 groups, 37 with normoinsulinemia (NI) and 20 with HI based on results of a 75-g oral glucose tolerance test.
Takashi, Ashikaga, Mitsuhiro, Nishizaki, Hiroyuki, Fujii, Kensuke, Ihara, Saori, Niki, Tadashi, Murai, Shingo, Maeda, Noriyoshi, Yamawake, Yukio, Kishi, Mitsuaki, Isobe   +9 more
openaire   +2 more sources

Interventional therapies for chronic heart failure: An overview of recent developments

ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo, Si Shi, Yutong Guo, Jie Xiong, Bo Wang, Zengxiang Dong, Dianyu Gao, Yingfeng Tu   +7 more
wiley   +1 more source

Implementation of Microcirculation Examination in Clinical Practice—Insights from the Nationwide POL-MKW Registry

Medicina
Background and Objectives: The assessment of coronary microcirculation may facilitate risk stratification and treatment adjustment. The aim of this study was to evaluate patients’ clinical presentation and treatment following coronary microcirculation ...
Rafał Januszek, Łukasz Kołtowski, Mariusz Tomaniak, Wojciech Wańha, Wojciech Wojakowski, Marek Grygier, Wojciech Siłka, Grzegorz Jan Horszczaruk, Bartosz Czarniak, Radosław Kręcki, Bartłomiej Guzik, Jacek Legutko, Tomasz Pawłowski, Paweł Wnęk, Marek Roik, Sylwia Sławek-Szmyt, Miłosz Jaguszewski, Tomasz Roleder, Miłosz Dziarmaga, Stanisław Bartuś   +19 more
doaj   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine
Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic dysfunction despite a preserved left ventricular ejection fraction, and visceral adipose tissue is implicated in its pathogenesis.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
doaj   +1 more source

Vascular dysfunction in women with recurrent pregnancy loss: Possible association with antiphospholipid antibodies

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 206-214, April 2025.
Abstract Objective Antiphospholipid antibodies (aPL) are recognized to have a pivotal role in recurrent pregnancy loss (RPL) and cardiovascular disease. Therefore, we assessed the vascular function of women with RPL and examined the association with each type of aPL.
Titi Yang, Emi Okada, Maho Todoroki, Siyu Liu, Rukmali Athurupana, Kumie Kataoka, Chiaki Kashino, Takashi Mitsui, Toru Hasegawa, Yasuhiko Kamada, Hisashi Masuyama, Mikiya Nakatsuka   +11 more
wiley   +1 more source