Results 81 to 90 of about 1,009,765 (207)

The effect of repeated hot water immersion on microvascular function, glycaemic control and inflammation in White European and South Asian males

Experimental Physiology, EarlyView.
Abstract Individuals of South Asian (SA) descent display a higher risk for cardiovascular disease and type 2 diabetes mellitus than their White European (WE) counterparts. Heat therapy, such as hot water immersion (HWI), can improve microvascular function and glycaemic control, although effects across racial groups are unknown.
David Bellini, Alex Lloyd, Christof A. Leicht, Stephen J. Bailey, Lewis J. James, Matthew J. Maley   +5 more
wiley   +1 more source

The short-chain fatty acid propionate prevents ox-LDL-induced coronary microvascular dysfunction by alleviating endoplasmic reticulum stress in HCMECs.

PLoS ONE
Coronary microvascular dysfunction (CMD) is a critical pathogenesis of cardiovascular diseases. Lower endothelial nitric oxide synthase (eNOS) phosphorylation leads to reduced endothelium-derived relaxing factor nitric oxide (NO) generation, causing and ...
Dan Hong, Wen Tang, Fei Li, Yating Liu, Xiao Fu, Qin Xu   +5 more
doaj   +1 more source

Should We Revisit the Clinical Value of Fractional Flow Reserve in the Era of Coronary Microvascular Dysfunction?

Biomedicines
The understanding of coronary artery disease is evolving, with more attention given currently to the microcirculation compartment. Coronary microvascular dysfunction (CMD) is defined by any structural or functional alteration of the coronary ...
Georgiana Pintea Bentea, Ahmad Awada, Brahim Berdaoui   +2 more
doaj   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

The Coronary Microcirculation Re-explored:Pathophysiological Insights and Clinical Implications [PDF]

Coronary microvascular dysfunction (CMD) is being increasingly recognised as a significant contributor to myocardial ischaemia, particularly in patients without obstructive coronary artery disease.
Abdimalik, Mustafa, Abo Al Hayja, Muntasir, Lip, Gregory Yh, Abdelrahim, Mohanad, Giblett, Joel, Fisher, Michael, Elamin, Ahmed, Fairbairn, Tim, Al Hayja, Muntasir Abo   +8 more
core   +1 more source

Relation between mild renal dysfunction and outcomes after coronary artery bypass grafting [PDF]

, 2005
Background: Risk stratification algorithms for coronary artery bypass grafting (CABG) do not include a weighting for preoperative mild renal impairment defined as a serum creatinine 130 to 199 micromol/L (1.47 to 2.25 mg/dL), which may impact mortality ...
Bonser, Robert, Freemantle, Nick, Rooney, SJ, Cramb, Robert, Pagano, Domenico, Wilson, I. C., Zakeri, R, Lipkin, Graham, Graham, Timothy, Barnet, V, Bonser, R. S., Graham, T. R., Cramb, R., Barnett, V., Freemantle, N., Keogh, B. E., Pagano, D., Keogh, Bruce, Wilson, IC, Barnett, V, Rooney, S. J., Lipkin, G. W., Zakeri, R., Domenico Pagano, Nick Freemantle, Rosita Zakeri, Timothy R. Graham, Robert Cramb, Ian C. Wilson, Vivian Barnett, Robert S. Bonser, Graham W. Lipkin, Bruce E. Keogh, Stephen J. Rooney   +33 more
core   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Effect of smoking cessation on microcirculation and endothelial dysfunction in patients with coronary heart disease.

Clinical Medicine (Russian Journal), 2018
Introduction. The promotion of quitting smoking in recent years is becoming increasingly popular. Many researchers recognize this measure as the most effective in primary and secondary prevention in cardiac patients. Deep mechanisms, through which the positive effect of quitting smoking is realized, continue to be studied.
N. V. Korneeva, B. Z. Sirotin
openaire   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

Investigating the effects of asymmetric dimethylarginine in the microcirculation [PDF]

Coronary resistance arteries develop spontaneous myogenic tone in response to intraluminal pressure, this autoregulation helps to couple blood flow to match metabolic demands of the myocardium. Endothelial dysfunction, involving the loss of nitric oxide (
Ng, Yu Yeung Hanson
core   +1 more source