Results 61 to 70 of about 44,957 (175)
Chemistry – A European Journal, EarlyView.Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier +7 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma +13 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin +10 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Ai‐Xia Song +7 more
wiley +1 more source
Photogenerated fluphenazine radical cations for antiviral functionalization of polypropylene masks
Polymer International, EarlyView.Fluphenazine impregnated into nonwoven polypropylene masks is photoexcited to a radical cation, which inactivates viruses on the polymer surface without causing damage to the masks. Abstract The incorporation of photoactive molecules into polymeric substrates offers a compelling route to introduce advanced functionality while preserving the host ...
Lilian Martins‐Nascimento +4 more
wiley +1 more source
Wildlife Letters, EarlyView.The Amur tiger, an endangered flagship species mainly found in the Russia Far East and Northeastern China, holds immense biological importance, and has been listed under the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES).
Wei Xie +15 more
wiley +1 more source
Favipiravir as RNA Polymerase Dependent (Rdrp) in COVID-19
, 2021 Coronavirus disease 2019 or Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a new virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This disease became a pandemic and is being discussed around world because it has
Suharto, Fadel Fikri
core
A computational approach to drug repurposing against SARS-CoV-2 RNA dependent RNA polymerase (RdRp)
, 2020 The spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused a worldwide outbreak of coronavirus disease 19 (COVID-19), which rapidly evolved as a global concern.
Memo, Maurizio +5 more
core +1 more source
Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase
, 2021 Coronavirus Disease 2019 (COVID-19) is a deadly emerging infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Because SARS-CoV-2 is easily transmitted through the air and has a relatively long incubation time, COVID ...
Pouya Hassandarvish +14 more
core +1 more source
British Journal of Haematology, EarlyView.Abnormal neutrophils and platelets in splenectomised β‐thalassaemia/haemoglobin E (HbE) disease contribute to neutrophil–platelet aggregation, leading to a high risk of thrombus formation. Activated platelets induce neutrophils to generate neutrophil extracellular trap (NETs) via the P‐selectin–P‐selectin glycoprotein ligand‐1 (PSGL1) pathway, which ...
Rattanawan Thubthed +11 more
wiley +1 more source