Results 41 to 50 of about 44,957 (175)

RdRp (RNA-dependent RNA polymerase): A key target providing anti-virals for the management of various viral diseases [PDF]

, 2022
With the arrival of the Covid-19 pandemic, anti-viral agents have regained center stage in the arena of medicine. Out of the various drug targets involved in managing RNA-viral infections, the one that dominates almost all RNA viruses is RdRp (RNA ...
Rawal Ravindra K, Singh Pankaj Kumar, Pathania Shelly   +2 more
core   +1 more source

Genomic Characterization of Severe Acute Respiratory Syndrome-Related Coronavirus in European Bats and Classification of Coronaviruses Based on Partial RNA-Dependent RNA Polymerase Gene Sequences [PDF]

Journal of Virology, 2010
ABSTRACT Bats may host emerging viruses, including coronaviruses (CoV). We conducted an evaluation of CoV in rhinolophid and vespertilionid bat species common in Europe. Rhinolophids carried severe acute respiratory syndrome (SARS)-related CoV at high frequencies and concentrations (26% of animals are positive; up to 2.4 × 10
Jan Felix, Drexler, Florian, Gloza-Rausch, Jörg, Glende, Victor Max, Corman, Doreen, Muth, Matthias, Goettsche, Antje, Seebens, Matthias, Niedrig, Susanne, Pfefferle, Stoian, Yordanov, Lyubomir, Zhelyazkov, Uwe, Hermanns, Peter, Vallo, Alexander, Lukashev, Marcel Alexander, Müller, Hongkui, Deng, Georg, Herrler, Christian, Drosten   +17 more
openaire   +5 more sources

Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019

Clinical Infectious Diseases, 2020
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered virus for which remdesivir is the only antiviral available. We report the occurrence of a mutation in RdRP (D484Y) following treatment with remdesivir in a 76-year-old female with post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 ...
Martinot, Martin, Jary, Aude, Fafi-Kremer, Samira, Leducq, Valentin, Delagreverie, Heloise, Garnier, Marc, Pacanowski, Jérôme, Mékinian, Arsène, Pirenne, France, Tiberghien, Pierre, Calvez, Vincent, Humbrecht, Catherine, Marcelin, Anne-Geneviève, Lacombe, Karine   +13 more
openaire   +5 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus [PDF]

, 2011
We provide experimental evidence of a replication enhancer element (REE) within the capsid gene of tick-borne encephalitis virus (TBEV, genus Flavivirus).
I. M. Jones, Gould, EA, Tuplin, Andrew, Gould, E. A., A. Buckley, E. A. Gould, A. Tuplin, Tuplin, A., Jones, I. M., Jones, I. M. (Ian M.), Buckley, A., Gould, E., T. S. Gritsun, Jones, IM, Gritsun, T. S., Tuplin, A, Evans, DJ, Evans, David J., Gritsun, TS, D. J. Evans, Evans, D. J., Buckley, A   +21 more
core   +1 more source

Sensitive and Spatially‐Resolved Electrochemiluminescence via Micropatterning

Advanced Materials Interfaces, EarlyView.
The use of a simple silica nanoparticle surface coating and patterning process can transform ordinary gold electrodes into multiplexed ECL sensing electrodes. Through spatially confined droplet formation and local ECL emission, it is possible to perform multiple analyses simultaneously from individual locations as well as intensify the ECL signal by as
Yuliang Shao, Tatiana Starikova, Mengzhen Xi, Maria Vittoria Balli, Emanuele Luigi Sciuto, Gabriele Giagu, Vincenzo Paratore, Carmelo Corsaro, Enza Fazio, Sabrina Conoci, Luca Prodi, Giovanni Valenti, Pavel A. Levkin   +12 more
wiley   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Seeking antiviral drugs to inhibit SARS-CoV-2 RNA dependent RNA polymerase: A molecular docking analysis

, 2022
COVID-19 outbreak associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) raised health concerns across the globe and has been considered highly transmissible between people.
Khater, Ibrahim, Nassar, Aaya
core   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source