Results 31 to 40 of about 44,957 (175)

Sandacrabins – Structurally unique antiviral RNA polymerase inhibitors from a rare myxobacterium

, 2021
We report structure elucidation and total synthesis of five unprecedented terpenoid-alkaloids, the sandacrabins, alongside with the first description of their producing organism Sandaracinus defensii MSr10575, which expands the Sandaracineae family by ...
Christine, Walt, Matthias, Götte, Ronald, Garcia, Alexander, Kiefer, Rolf, Müller, Sibylle, Haid, Fabian, Panter, Cathrin, Spröer, Thomas, Pietschmann, Egor, Tchesnokov, Chantal, Bader, Jörg, Overmann   +11 more
core   +1 more source

In silico evaluation of isatin-based derivatives with RNA-dependent RNA polymerase of the novel coronavirus SARS-CoV-2

Journal of Biomolecular Structure and Dynamics, 2020
Isatin (1H-indole-2,3-dione)-containing compounds have been shown to possess several remarkable biological activities. We had previously explored a few isatin-based imidazole derivatives for their predicted dual activity against both inflammation and cancer.
Rajesh Kumar M, Daniel Andrew Gideon, Richard Mariadasse, Vijay Nirusimhan, Sherlin Rosita. A, Jesu Castin E, Jeyaraman Jeyakanthan, V. Violet Dhayabaran   +7 more
openaire   +4 more sources

An Analysis of Inhibition of the Severe Acute Respiratory Syndrome Coronavirus 2 RNA-dependent Rna Polymerase By Zinc Ion: an in silico Approach

Future Virology, 2021
Background: Coronavirus disease 2019 is caused by exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was reported that Zn(2+) is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV). We hypothesize that the same applies to the newly discovered SARS-CoV-2. Material & methods: We compared the structure of RNA-
Sina Zoghi, Hossein Jafari Khamirani, Seyed Alireza Dastgheib, Mehdi Dianatpour, Alireza Ghaffarieh   +4 more
openaire   +2 more sources

5′-Proximal Hot Spot for an Inducible Positive-to-Negative-Strand Template Switch byCoronavirus RNA-Dependent RNA Polymerase [PDF]

Journal of Virology, 2007
ABSTRACT Coronaviruses have a positive-strand RNA genome and replicate through the use of a 3′ nested set of subgenomic mRNAs each possessing a leader (65 to 90 nucleotides [nt] in length, depending on the viral species) identical to and derived from the genomic leader.
Hung-Yi, Wu, David A, Brian
openaire   +2 more sources

Evaluating the potential of different inhibitors on RNA-dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2: A molecular modeling approach

Medical Journal Armed Forces India, 2021
Coronavirus disease 2019 (COVID-19) has already affected 2883603 and killed 198842 people, as of April 27, 2020. Because there is no specific therapeutic drug, drug repurposing has been proposed. RNA-dependent RNA polymerase (RdRp) is a promising drug against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to control its replication, and ...
Choudhury, Shuvasish, Moulick, Debojyoti, Saikia, Purbajyoti, Mazumder, Muhammed Khairujjaman   +3 more
openaire   +2 more sources

Beclabuvir can Inhibit the RNA-dependent RNA Polymerase of Newly Emerged Novel Coronavirus (SARS-CoV-2)

, 2020
Recent emergence of novel coronavirus (SARS-CoV-2) all over the world has resulted more than 33,106 global deaths. To date well-established therapeutics modules for infected patients are unknown. In this present initiative, molecular interactions between FDA-approved antiviral drugs against the Hepatitis-C virus (HCV) have been investigated ...
Kunal Dutta, Sergey Shityakov, Olga Morozova, Ibrahim Khalifa, Jin Zhang, Wei Zhu, Amiya Panda, Chandradipa Ghosh   +7 more
openaire   +4 more sources

Remdesivir Strongly Binds to both RNA-dependent RNA Polymerase and Main Protease of SARS-CoV-2: Evidence from Molecular Simulations

, 2020
The outbreak of a new coronavirus SARS-CoV-2 (severe acute respiratory syndrome–coronavirus 2) has caused a global CoVid-19 (coronavirus disease 2019) pandemic, resulting in millions of infections and thousands of deaths around the world.
Duc Toan, Truong, Hoang Linh, Nguyen, Thai, Nguyen, Mai Suan, Li   +3 more
core   +1 more source

Decoding the structure of RNA-dependent RNA-polymerase (RdRp), understanding the ancestral relationship and dispersion pattern of 2019 Wuhan Coronavirus [PDF]

, 2020
Abstract Most recently, an outbreak of severe pneumonia caused by the infection of 2019-nCoV, a novel coronavirus first identified in Wuhan, China, imposes serious threats to public health. Upon infecting host cells, coronaviruses assemble a multi-subunit RNA-synthesis complex of viral non-structural proteins (nsp) responsible for the ...
Abbas Khan, Mazhar Khan, Shoaib Saleem, Zainib Babar, Arif Ali, Abdul Aziz Khan, Zain Sardar, Fahad Hamayun, Syed Shujait Ali, Dong-Qing Wei   +9 more
openaire   +1 more source

In vitro and in vivo expression of foreign genes by transmissible gastroenteritis coronavirus-derived minigenomes

, 2002
A helper-dependent expression system based on transmissible gastroenteritis coronavirus (TGEV) has been developed using a minigenome of 3·9 kb (M39).
Enjuanes, L., Plana-Duran, J., Reimann, I., Moormann, R.J.M., Sola, I., Plana Duran, J., Alonso, S., Izeta, A., Teifke, J.P., Teifke, Jens Peter, Reimann, Ilona, Balasch, M.   +11 more
core   +1 more source

Functional domains of the influenza A virus PB2 protein:identification of NP- and PB1-binding sites

, 2004
Influenza virus genomic RNA segments are packaged into ribonucleoprotein (RNP) structures by the PB1, PB2, and PA subunits of an RNA polymerase and a single-strand RNA-binding nucleoprotein (NP).
Poole, Emma, Digard, Paul, Medcalf, Liz, Elton, Debra, Poole, Emma L   +4 more
core   +1 more source