Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6/2 Mouse Model of HD [PDF]
, 2013 Huntington's disease (HD) is caused by the expansion of a CAG repeat in the huntingtin (HTT) gene. The R6/2 mouse model of HD expresses a mutant version of exon 1 HTT and develops motor and cognitive impairments, a widespread huntingtin (HTT) aggregate ...
A Kuhn +58 more
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Note on the Arteries of the Corpus Striatum [PDF]
The Boston Medical and Surgical Journal, 1907 n ...
Ayer, James B., Aitken, H. F.
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Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria [PDF]
, 2018 We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID ...
Battaglia, Giuseppe +12 more
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Averaging Transformations of Synaptic Potentials on Networks [PDF]
, 2009 The problem of the transformation of microscopic information to the macroscopic level is an intriguing challenge in computational neuroscience, but also of general mathematical importance.
Hamid Reza Noori
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Semi-automatic parcellation of the corpus striatum [PDF]
SPIE Proceedings, 2007 The striatum is the input component of the basal ganglia from the cerebral cortex. It includes the caudate, putamen, and nucleus accumbens. Thus, the striatum is an important component in limbic frontal-subcortical circuitry and is believed to be relevant both for reward-guided behaviors and for the expression of psychosis.
James J. Levitt +4 more
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Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy. [PDF]
, 2015 BackgroundMultiple system atrophy (MSA) is a neurodegenerative disease characterized by parkinsonism, ataxia and dysautonomia. Histopathologically, the hallmark of MSA is the abnormal accumulation of alpha-synuclein (α-syn) within oligodendroglial cells,
Adame, Anthony +12 more
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A structural magnetic resonance imaging study in transgender persons on cross-sex hormone therapy [PDF]
, 2016 <b><i>Background:</i></b> To date, research findings are inconsistent about whether the neuroanatomy in transgender persons resembles that of their natal sex or their gender identity.
Landré, Lionel +3 more
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Topography and structure of corpus striatum in Insectivora [PDF]
Acta Theriologica, 1987 The telencephalon was studied in three species of Insectivora: Sorex araneus, Neomys fodiens and Talpa europaea. The material was fixed in formalin, dehydrated in ethyl alcohol, embedded in paraffin and cut into transverse sections 15 µm thick. The sections were stained by the methods of Nissl and Kluver and Barrera.
Szteyn, S. +2 more
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Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]
, 2006 Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M. +3 more
core +2 more sources
Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease [PDF]
, 1993 Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were studied in postmortem brain tissue from patients with histopathologically confirmed Parkinson's disease and matched control subjects.
Jenner, P. +3 more
core +1 more source