Results 111 to 120 of about 493,059 (305)

Decreased Neuron Density and Increased Glia Density in the Ventromedial Prefrontal Cortex (Brodmann Area 25) in Williams Syndrome. [PDF]

, 2018
Williams Syndrome (WS) is a neurodevelopmental disorder caused by a deletion of 25⁻28 genes on chromosome 7 and characterized by a specific behavioral phenotype, which includes hypersociability and anxiety.
Bellugi, Ursula, Hanson, Kari L, Lew, Caroline H, Semendeferi, Katerina, Wilder, Linnea   +4 more
core   +2 more sources

Lower cerebral blood flow but not cerebrovascular response in elastin haploinsufficient mice

Experimental Physiology, EarlyView.
Abstract Elastin insufficiency is associated with structural differences in the large elastic arteries and cerebral artery dysfunction. However, previous studies have not assessed potential sex differences in cerebrovascular function. We measured cerebral blood flow (CBF) using arterial spin labeling MRI at rest and in response to hypercapnia challenge
Abigail E. Cullen, Emily H. Reeve, Nick R. Winder, Grant D. Henson, Nayantara Arora, Thomas Leonhardt, Ainsley Hogan, Sahana Krishna Kumaran, Naly Setthavonsack, Victoria Krajbich, Art Riddle, Benjamin Zimmerman, Nabil J. Alkayed, Martin M. Pike, Randall L. Woltjer, Ashley E. Walker   +15 more
wiley   +1 more source

Complementarity of BOLD and ADC‐fMRI in Mapping Brain Visual Processing in the Rat

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
BOLD‐fMRI and ADC‐fMRI were acquired at 9.4 and 14 T during visual stimulation with variable frequency. BOLD‐fMRI showed robust positive/negative responses but depended on regional vascularization patterns. ADC‐fMRI was able to detect neural activity independently from vascular effects at 9.4 T.
Jean‐Baptiste Pérot, Andreea Hertanu, Arthur Spencer, Jasmine Nguyen‐Duc, Nikolaos Molochidis, Valerio Zerbi, Maxime Yon, Ileana Jelescu   +7 more
wiley   +1 more source

Non‐Invasive, High‐Resolution (1H2O) Metabolic Activity Diffusion Imaging [MADI] of Rat Glioma

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
We employed Metabolic Activity Diffusion Imaging [MADI] and 18FDG‐PET in rats with syngeneic RG2 glioblastoma brain tumors. MADI quantifies kio (the cellular H2O efflux rate constant), cell volume (V), and cell density (ρ), without the use of contrast agents. The kioV product quantifies the rate of water efflux per cell.
Joshua W. Schlegel, Samantha M. Holland, Felice D. Kelly, Eric M. Baker, Jared Stoller, William Packwood, Xin Li, Ramon F. Barajas Jr., Charles S. Springer Jr., Martin M. Pike   +9 more
wiley   +1 more source

Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature

Brain and Behavior, Volume 16, Issue 2, February 2026.
Executive dysfunction in Huntington's disease follows a selective, stage‐dependent pattern, with early deficits in psychomotor speed, cognitive flexibility, inhibition, and working‐memory updating. Progression is associated with broader impairments in planning and attention.
Simone Migliore, Martina Marcaccio, Ilaria Di Pompeo, Massimo Marano, Giuseppe Curcio   +4 more
wiley   +1 more source

Geometric Microstructural Characteristics of White Matter Differentiate Patients With Facial Dyskinesias and Palsy

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Patients with facial dyskinesias and palsy show distinct white matter geometric microstructural patterns. Meige's syndrome patients exhibit markedly altered white matter integrity and geometry, while facial palsy patients' white matter features correlate with clinical severity.
Hua Zhu, Aocai Yang, Jixin Luan, Manxi Xu, Bing Liu, Kuan Lv, Pianpian Hu, Amir Shmuel, Haogang Zhu, Zhen Yuan, Ni Shu, Jian Cheng, Guolin Ma   +12 more
wiley   +1 more source

Diffusion MRI marks progressive alterations in fiber integrity in the zQ175DN mouse model of Huntington's disease

Neurobiology of Disease
Huntington's disease (HD) is a progressive neurodegenerative disease affecting motor and cognitive abilities. Multiple studies have found white matter anomalies in HD-affected humans and animal models of HD.
Nicholas Vidas-Guscic, Joëlle van Rijswijk, Johan Van Audekerke, Ben Jeurissen, Israel Nnah, Haiying Tang, Ignacio Muñoz-Sanjuan, Dorian Pustina, Roger Cachope, Annemie Van der Linden, Daniele Bertoglio, Marleen Verhoye   +11 more
doaj   +1 more source

Extensive Axonal and Glial Fiber Growth from Fetal Porcine Cortical Xenografts in the Adult Rat Cortex

Cell Transplantation, 1995
Axonal growth from cortically placed fetal neural transplants to subcortical targets in adult hosts has been difficult to demonstrate and is assumed to be minimal; however, experiments using xenogeneic neural grafts of either human or porcine fetal ...
Antony R. Garcia, Terrence W. Deacon, Jonathan Dinsmore, Ole Isacson   +3 more
doaj   +1 more source

Lentivirus-mediated Persephin over-expression in Parkinson′s disease rats

Neural Regeneration Research, 2015
Persephin, together with glial cell line-derived neurotrophic factor and neurturin, has a neurotrophic effect and promotes the survival of motor neurons cultured in vitro.
Xiao-feng Yin, Hua-min Xu, Yun-xia Jiang, Yun-lai Zhi, Yu-xiu Liu, Heng-wei Xiang, Kai Liu, Xiao-dong Ding, Peng Sun   +8 more
doaj   +1 more source

Prolactin Receptor Deficiency Promotes Hypomyelination in White Matter Tracts During Postnatal Central Nervous System Maturation in Mice

Glia, Volume 74, Issue 2, February 2026.
Prolactin action is essential for proper myelination of white matter tracts during neonatal and prepubertal stages in mice. Lack of prolactin receptor (Prlr−/−) signaling leads to hypomyelination and impaired locomotor function. ABSTRACT A large wave of myelination in the central nervous system (CNS) of mammals occurs during postnatal development ...
Ana L. Ocampo‐Ruiz, José L. Dena‐Beltrán, Marco A. Dimas‐Rufino, Ximena Castillo, Dina I. Vazquez‐Carrillo, Andrea Silos‐Guajardo, Xarubet Ruiz‐Herrera, Edith Garay, Gonzalo Martínez de la Escalera, Carmen Clapp, Rogelio O. Arellano, Abraham J. Cisneros‐Mejorado, Yazmín Macotela   +12 more
wiley   +1 more source