Amphetamine and pseudoephedrine cross-tolerance measured by c-Fos protein expression in brains of chronically treated rats [PDF]
, 2008 Background Pseudoephedrine is a drug commonly prescribed as a nasal decongestant and bronchodilator and is also freely available in cold remedies and medications.
Casalotti, Stefano O. +3 more
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PLoS ONE, 2023 In this study, we investigated the role of glutamate delta 1 receptor (GluD1) in oligodendrocyte progenitor cell (OPC)-mediated myelination during basal (development) and pathophysiological (cuprizone-induced demyelination) conditions.
Sukanya G Gakare +3 more
doaj +1 more source
Acta Neuropathologica Communications, 2017 Multiple system atrophy (MSA) is a horrible and unrelenting neurodegenerative disorder with an uncertain etiology and pathophysiology. MSA is a unique proteinopathy in which alpha-synuclein (α-syn) accumulates preferentially in oligodendroglia rather ...
Ronald J. Mandel +7 more
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Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington’s Disease
Antioxidants, 2021 Huntington’s disease (HD) is caused by expansion of polyglutamine repeats in the protein huntingtin, which affects the corpus striatum of the brain. The polyglutamine repeats in mutant huntingtin cause its aggregation and elicit toxicity by affecting ...
Bindu D. Paul
doaj +1 more source
The Influence of Striatal Astrocyte Dysfunction on Locomotor Activity in Dopamine-depleted Rats
Basic and Clinical Neuroscience, 2021 Introduction: Astrocyte dysfunction is the common pathology failing astrocyte-neuron interaction in neurological diseases, including Parkinson’s Disease (PD).
Dmitry Voronkov +5 more
doaj
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy. [PDF]
, 2015 BackgroundMultiple system atrophy (MSA) is a neurodegenerative disease characterized by parkinsonism, ataxia and dysautonomia. Histopathologically, the hallmark of MSA is the abnormal accumulation of alpha-synuclein (α-syn) within oligodendroglial cells,
Adame, Anthony +12 more
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Resuscitation of newborn piglets. short-term influence of FiO2 on matrix metalloproteinases, caspase-3 and BDNF. [PDF]
PLoS ONE, 2010 BACKGROUND: Perinatal hypoxia-ischemia is a major cause of mortality and cerebral morbidity, and using oxygen during newborn resuscitation may further harm the brain.
Rønnaug Solberg +7 more
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Compulsive Social Behavior Emerges after Selective Ablation of Striatal Cholinergic Interneurons [PDF]
, 2017 The mechanisms underlying social dysfunction in neuropsychiatric conditions like obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) remain uncertain. Dysfunctions in basal ganglia, including reduced number of striatal cholinergic interneurons
Beccaria, Juan Pablo +4 more
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Pathogenetical significance of porencephalic lesions associated with intracerebral inoculation of sheep with the bovine spongiform encephalopathy (BSE) agent [PDF]
, 2009 Decreased rates of transmission of transmissible spongiform encephalopathies (TSEs) to sheep have been attributed to some polymorphisms of the prion protein (PrP) and to a ‘species barrier’ on interspecies experiments.
Card +21 more
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Connectivity Alterations in Vascular Parkinsonism: A Structural Covariance Study
Applied Sciences, 2022 This study aimed to investigate the structural covariance between the striatum and large-scale brain regions in patients with vascular parkinsonism (VP) compared to Parkinson’s disease (PD) and control subjects, and then explore the relationship between ...
Fabiana Novellino +8 more
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