The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system. [PDF]
, 1992 Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD50 of less than 0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD50 of 10(4.2) PFU.
Bloom, F +3 more
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Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. [PDF]
, 2009 Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography ...
Jagust, WJ, Rabinovici, GD
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17 Β-Estradiol Oxidative Stress Attenuation And Autophagy-Induced Dopaminergic Neuroprotection
Cell Journal, 2018 Objective Degeneration of dopaminergic neurons in the substantia nigra of the brain stem is the main pathological aspect of Parkinson’s disease (PD). 17 β-estradiol (E2) has neuroprotective effects on substantia nigra, however, the underlined mechanism ...
Roya Varmazyar +4 more
doaj +1 more source
Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson's disease. [PDF]
PLoS ONE, 2011 Establishing the neurological basis of behavioural dysfunction is key to provide a better understanding of Parkinson's disease (PD) and facilitate development of effective novel therapies. For this, the relationships between longitudinal structural brain
Anthony C Vernon +3 more
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The third man: Robert Dunn’s (1799-1877) contribution to aphasia research in mid 19th century England [PDF]
, 2016 Throughout his medical career, Robert Dunn (1799-1877) published a number of clinical cases with post-mortem reports involving acquired language disorders, the first noted in 1842.
Lorch, Marjorie
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Abnormal white matter tracts resembling pencil fibers involving prefrontal cortex (Brodmann area 47) in autism: a case report. [PDF]
, 2016 BackgroundAutism is not correlated with any neuropathological hallmark as the brain of autistic individuals lack defined lesions. However, previous investigations have reported cortical heterotopias and local distortion of the cytoarchitecture of the ...
Ariza, Jeanelle +4 more
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When Alcoholism Affects Memory Functions: MRI of the Brain. [PDF]
, 1995 The development of modern imaging techniques makes it possible to examine directly the relationship between brain abnormalities and memory impairment.
Jernigan, Terry L, Ostergaard, Arne L
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An adverse drug interaction of haloperidol with levodopa
Indian Journal of Psychological Medicine, 2015 Drug interactions are known to play a significant role in the incidence of adverse drug reactions (ADRs) both in the community and in hospitals. Both the newer atypical antipsychotics and their more traditional counterparts are subject to drug - drug ...
Jisha M Lucca +3 more
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Anatomic and Molecular Development of Corticostriatal Projection Neurons in Mice [PDF]
, 2013 Corticostriatal projection neurons (CStrPN) project from the neocortex to ipsilateral and contralateral striata to control and coordinate motor programs and movement.
Kotchetkov, Ivan S. +4 more
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2017 Objective To investigate the structure of corpus striatum and the integrity of white matter fiber in patients with Parkinson's disease (PD) and idiopathic rapid eye movement sleep behavior disorder (iRBD).
Ya-meng ZHANG +6 more
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