Results 61 to 70 of about 462,073 (262)
NeuroImage, 2020 The internal structure of the human hippocampus is challenging to map using histology or neuroimaging due to its complex archicortical folding. Here, we aimed to overcome this challenge using a unique combination of three methods.
J. DeKraker +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Gyrification of the cerebral cortex requires FGF signaling in the mammalian brain
eLife, 2017 Although it has been believed that the evolution of cortical folds was a milestone, allowing for an increase in the number of neurons in the cerebral cortex, the mechanisms underlying the formation of cortical folds are largely unknown.
Naoyuki Matsumoto +3 more
doaj +1 more source
Deviant cortical sulcation related to schizophrenia and cognitive deficits in the second trimester
Translational Neuroscience, 2020 Aberrant cortical development, inferred from cortical folding, is linked to the risk of schizophrenia. Cortical folds develop in a time-locked fashion during fetal growth.
MacKinley Michael Lloyd +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source
, 2019 During fetal development the human brain transforms from a smooth-surfaced organ to one with many folds. Interestingly, not all mammalian brains undergo cortical folding, and of those that do, folding complexity varies greatly between species.
SHREYA RANA (6999410)
core +1 more source
Regional impairments of cortical folding in premature infants [PDF]
Annals of Neurology, 2014 ObjectiveThis study was undertaken to evaluate the influence of preterm birth and other factors on cerebral cortical maturation.MethodsWe have evaluated the effects of preterm birth on cortical folding by applying cortical cartography methods to a cohort of 52 preterm infants (<31 weeks gestation, mild or no injury on conventional magnetic resonance
Engelhardt, Erin +6 more
openaire +2 more sources
FEBS Open Bio, EarlyView.The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao +23 more
wiley +1 more source
Systematic cortical thickness and curvature patterns in primates
NeuroImage, 2023 Humans are known to have significant and consistent differences in thickness throughout the cortex, with thick outer gyral folds and thin inner sulcal folds.
Nagehan Demirci +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou +16 more
wiley +1 more source