Results 41 to 50 of about 462,073 (262)

Folding of the Cerebral Cortex Requires Cdk5 in Upper-Layer Neurons in Gyrencephalic Mammals

Cell Reports, 2017
Folds in the cerebral cortex in mammals are believed to be key structures for accommodating increased cortical neurons in the cranial cavity. However, the mechanisms underlying cortical folding remain largely unknown, mainly because genetic manipulations
Yohei Shinmyo, Yukari Terashita, Tung Anh Dinh Duong, Toshihide Horiike, Muneo Kawasumi, Kazuyoshi Hosomichi, Atsushi Tajima, Hiroshi Kawasaki   +7 more
doaj   +1 more source

“Plis De Passage” Deserve a Role in Models of the Cortical Folding Process [PDF]

Brain Topography, 2019
Yann Le Guen, Vincent Frouin, Jean-Francois Mangin   +2 more
exaly   +2 more sources

The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice

eLife, 2016
Cortical expansion and folding are often linked to the evolution of higher intelligence, but molecular and cellular mechanisms underlying cortical folding remain poorly understood. The hominoid-specific gene TBC1D3 undergoes segmental duplications during
Xiang-Chun Ju, Qiong-Qiong Hou, Ai-Li Sheng, Kong-Yan Wu, Yang Zhou, Ying Jin, Tieqiao Wen, Zhengang Yang, Xiaoqun Wang, Zhen-Ge Luo   +9 more
doaj   +1 more source

A model of tension-induced fiber growth predicts white matter organization during brain folding

Nature Communications, 2021
Associations have been established between brain folding and white matter connectivity. Here the authors show that axon elongation, in response to mechanical stresses during cortical expansion and folding, may be sufficient to induce tissue remodeling ...
Kara E. Garcia, Xiaojie Wang, Christopher D. Kroenke   +2 more
doaj   +1 more source

An essential role of SVZ progenitors in cortical folding in gyrencephalic mammals [PDF]

, 2016
Because folding of the cerebral cortex in the mammalian brain is believed to be crucial for higher brain functions, the mechanisms underlying its formation during development and evolution are of great interest.
25064, Masuda, Kosuke, 25066, Shinmyo, Yohei, 25065, Kawasaki, Hiroshi, 24011, 00418831, 190, Toda, Tomohisa, Dinh Duong, Tung Anh, 50303904   +11 more
core   +3 more sources

Cortical neurodevelopment in pre-manifest Huntington's disease

NeuroImage: Clinical, 2019
Background: The expression of the HTT CAG repeat expansion mutation causes neurodegeneration in Huntington's disease (HD). Objectives: In light of the – mainly in-vitro – evidence suggesting an additional role of huntingtin in neurodevelopment we used 3T
Katharina M. Kubera, Mike M. Schmitgen, Dusan Hirjak, Robert Christian Wolf, Michael Orth   +4 more
doaj   +1 more source

Shape variability of the central sulcus in the developing brain: A longitudinal descriptive and predictive study in preterm infants

NeuroImage, 2022
Despite growing evidence of links between sulcation and function in the adult brain, the folding dynamics, occurring mostly before normal-term-birth, is vastly unknown. Looking into the development of cortical sulci in infants can give us keys to address
Héloïse de Vareilles, Denis Rivière, Zhong-Yi Sun, Clara Fischer, François Leroy, Sara Neumane, Nuša Stopar, Rian Eijsermans, Marin Ballu, Maria-Luisa Tataranno, Manon Benders, Jean-François Mangin, Jessica Dubois   +12 more
doaj   +1 more source

Genetic Predisposition and Disease Expression of Bipolar Disorder Reflected in Shape Changes of the Anterior Limbic Network

Brain Sciences, 2019
Bipolar disorder (BD) is a genetically and phenotypically complex psychiatric disease. Although previous studies have suggested that the relatives of BD patients have an increased risk of experiencing affective disturbances, most relatives who have ...
Chia-Feng Lu, Yu-Te Wu, Shin Teng, Po-Shan Wang, Pei-Chi Tu, Tung-Ping Su, Chi-Wen Jao, Cheng-Ta Li   +7 more
doaj   +1 more source

Mechanical stress connects cortical folding to fiber organization in the developing brain. [PDF]

Trends Neurosci
During development of the gyrencephalic brain, both the formation of cortical folds and the establishment of axonal tracts require large, coordinated mechanical deformations. Cortical folding enables a high ratio of cortical surface area to brain volume,
Garcia KE, Kroenke CD, Bayly PV.
europepmc   +2 more sources

Genetic insights on the mechanisms of human cortical folding

Abstract The unique and intricate pattern of human cortical folding is rooted in fetal neurodevelopmental processes and can now be comprehensively quantified by new neuroimaging-derived measures of sulcal complexity. Here, we provide the first genetic maps of human sulcal complexity.
Snyder W, Shafee R, Liu S, Levitis E, Duan K, Kumar K, Schleifer CH, Boen R, Ching CR, Han JC, Lee N, Mulle JG, Shultz S, Jacquemont S, Bearden CE, Vértes PE, Bullmore ET, Raznahan A.   +17 more
europepmc   +4 more sources