Mechanics of Cortical Folding: Stress, Growth and Stability [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2018 Cortical folding, or gyrification, coincides with several important developmental processes. The folded shape of the human brain allows the cerebral cortex, the thin outer layer of neurons and their associated projections, to attain a large surface area relative to brain volume.
Christopher D Kroenke +2 more
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Mechanical hierarchy in the formation and modulation of cortical folding patterns [PDF]
Scientific Reports, 2023 The important mechanical parameters and their hierarchy in the growth and folding of the human brain have not been thoroughly understood. In this study, we developed a multiscale mechanical model to investigate how the interplay between initial ...
Poorya Chavoshnejad +6 more
doaj +2 more sources
Exploring the role of different cell types on cortical folding in the developing human brain through computational modeling [PDF]
Scientific ReportsThe human brain’s distinctive folding pattern has attracted the attention of researchers from different fields. Neuroscientists have provided insights into the role of four fundamental cell types crucial during embryonic development: radial glial cells ...
Mohammad Saeed Zarzor +4 more
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A Framework to Study the Cortical Folding Patterns
NeuroImage, 2004 This paper describes a decade long research program focused on the variability of the cortical folding patterns. The program has developed a framework of using artificial neuroanatomists that are trained to identify sulci from a database.
J. Régis +10 more
core +3 more sources
Cortical folding correlates to aging and Alzheimer’s Disease’s cognitive and CSF biomarkers [PDF]
Scientific ReportsThis manuscript presents the quantification and correlation of three aspects of Alzheimer’s Disease evolution, including structural, biochemical, and cognitive assessments.
Fernanda Hansen P. de Moraes +6 more
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Compensating cortical thickness for cortical folding-related variation. [PDF]
Imaging Neurosci (Camb)Abstract Cortical thickness is a widely used biomarker of brain morphology and health, yet it is dependent on local cortical folding. Because gyral crowns are consistently thicker than sulcal fundi and cortical folds vary widely across individuals, these fluctuations introduce unmodeled nuisance variance that can obscure meaningful ...
Demirci N +4 more
europepmc +4 more sources
The Subplate: A potential driver of cortical folding?
Cerebral Cortex, 2019 In many species of Mammalia, the surface of the brain develops from a smooth structure to one with many fissures and folds, allowing for vast expansion of the surface area of the cortex.
David Walker (18045133) +5 more
core +3 more sources
Effects of stress-dependent growth on evolution of sulcal direction and curvature in models of cortical folding. [PDF]
Brain Multiphys, 2023 The majority of human brain folding occurs during the third trimester of gestation. Although many studies have investigated the physical mechanisms of brain folding, a comprehensive understanding of this complex process has not yet been achieved.
Balouchzadeh R, Bayly PV, Garcia KE.
europepmc +2 more sources
Proneural Genes Define Ground-State Rules to Regulate Neurogenic Patterning and Cortical Folding [PDF]
Neuron, 2021 Imrul Faisal +2 more
exaly +2 more sources
Cortex2vector: anatomical embedding of cortical folding patterns. [PDF]
Cereb Cortex, 2023 Abstract Current brain mapping methods highly depend on the regularity, or commonality, of anatomical structure, by forcing the same atlas to be matched to different brains. As a result, individualized structural information can be overlooked.
Zhang L +6 more
europepmc +3 more sources