Results 21 to 30 of about 369,799 (284)

Malformations of Cortical Development

Brain Pathology, 2012
Abstract Structural abnormalities of the brain are increasingly recognized in patients that suffer from pharmacoresistant focal epilepsies by applying high‐resolution imaging techniques. In many of these patients, epilepsy surgery results in control of seizures.
Aronica, Eleonora, Becker, Albert J., Spreafico, Roberto   +2 more
  +6 more sources

Malformations of Cortical Development [PDF]

The Neurologist, 2008
Malformations of cortical development (MCD) are increasingly recognized as an important cause of epilepsy and developmental delay. MCD encompass a wide spectrum of disorders with various underlying genetic etiologies and clinical manifestations. High resolution imaging has dramatically improved our recognition of MCD.This review will provide a brief ...
Trudy, Pang, Ramin, Atefy, Volney, Sheen
openaire   +2 more sources

Adherens Junctions: Guardians of Cortical Development

Frontiers in Cell and Developmental Biology, 2020
Apical radial glia comprise the pseudostratified neuroepithelium lining the embryonic lateral ventricles and give rise to the extensive repertoire of pyramidal neuronal subtypes of the neocortex.
Lenin Veeraval, Conor J. O’Leary, Helen M. Cooper   +2 more
doaj   +1 more source

Bilateral generalized polymicrogyria (BGP) - A distinct syndrome of cortical malformation

, 2004
Background: Syndromes of bilateral symmetric polymicrogyria include an autosomal recessive form of bilateral frontoparietal polymicrogyria (BFPP), in which the malformation is most severe rostrally.
Barkovich, AJ, Walsh, CA, Topcu, M, Tezcan, K, Bodell, A, Grant, PE, Chang, BS, Scheffer, [No Value], Cascino, GD, Woods, CG, Leventer, RJ, Piao, [No Value], Giannini, C   +12 more
core   +5 more sources

Hemimegalencephaly: A rare congenital malformation of cortical development

Clinical Case Reports, 2021
Hemimegalencephaly is a rare congenital malformation of cortical development usually associated with developmental delay and refractory epilepsy that sooner or later require hemispherectomy.
Vikash Jaiswal, Muhammad Hanif, Zouina Sarfraz, Gaurav Nepal, Sidra Naz, Dattatreya Mukherjee, Samir Ruxmohan   +6 more
doaj   +1 more source

Malformations of cortical development and epilepsy [PDF]

Dialogues in Clinical Neuroscience, 2008
Malformations of cortical development (MCDs) are an important cause of epilepsy and an extremely interesting group of disorders from the perspective of brain development and its perturbations. Many new MCDs have been described in recent years as a result of improvements in imaging, genetic testing, and understanding of the effects of mutations on the ...
Leventer RJ, GUERRINI, RENZO, Dobyns W.B.   +2 more
openaire   +8 more sources

A human dynein heavy chain mutation impacts cortical progenitor cells causing developmental defects, reduced brain size and altered brain architecture

Neurobiology of Disease, 2023
Dynein heavy chain (DYNC1H1) mutations can either lead to severe cerebral cortical malformations, or alternatively may be associated with the development of spinal muscular atrophy with lower extremity predominance (SMA-LED). To assess the origin of such
Delfina M. Romero, Donia Zaidi, Carmen Cifuentes-Diaz, Camille Maillard, Gael Grannec, Mohammed Selloum, Marie-Christine Birling, Nadia Bahi-Buisson, Fiona Francis   +8 more
doaj   +1 more source

DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

eLife, 2021
Diaphanous (DIAPH) three (DIAPH3) is a member of the formin proteins that have the capacity to nucleate and elongate actin filaments and, therefore, to remodel the cytoskeleton.
Eva On-Chai Lau, Devid Damiani, Georges Chehade, Nuria Ruiz-Reig, Rana Saade, Yves Jossin, Mohamed Aittaleb, Olivier Schakman, Nicolas Tajeddine, Philippe Gailly, Fadel Tissir   +10 more
doaj   +1 more source

High-throughput, automated quantification of white matter neurons in mild malformation of cortical development in epilepsy [PDF]

, 2014
Introduction In epilepsy, the diagnosis of mild Malformation of Cortical Development type II (mMCD II) predominantly relies on the histopathological assessment of heterotopic neurons in the white matter.
Liu, J.Y.W., Ellis, M., Brooke-Ball, H., Brandner, S., de Tisi, J., Sisodiya, S.M., Eriksson, S.H., Thom, M.   +7 more
core   +1 more source

sj-docx-1-tan-10.1177_17562864211050027 – Supplemental material for Response to antiseizure medications in epileptic patients with malformation of cortical development

, 2021
Supplemental material, sj-docx-1-tan-10.1177_17562864211050027 for Response to antiseizure medications in epileptic patients with malformation of cortical development by Wei Chen, Bo Jin, Thandar Aung, Chenmin He, Cong Chen, Shan Wang, Yao Ding, Fang ...
Chenmin He (11563646), Haibin Dai (464649), Bo Jin (169366), Thandar Aung (11563643), Hong Li (20183), Wei Chen (23863), Junming Zhu (448145), Shuang Wang (46453), Cong Chen (325493), Yao Ding (1429924), Zhe Zheng (584306), Shan Wang (120085), Meiping Ding (113932), Fang Ding (222713), Yu Geng (592176), Chao Wang (146527), Biao Jiang (443263)   +16 more
core   +1 more source