Results 101 to 110 of about 469,575 (237)

Comparison of Transcriptional Activation by Corticosteroids of Human MR (Ile-180) and Human MR Haplotype (Ile180Val) [PDF]

arXiv
While the classical function of human mineralocorticoid receptor (MR) is to regulate sodium and potassium homeostasis through aldosterone activation of the kidney MR, the MR also is highly expressed in the brain, where the MR is activated by cortisol in response to stress. Here, we report the half-maximal response (EC50) and fold-activation by cortisol,
arxiv  

Identification of structural features in chemicals associated with cancer drug response: A systematic data-driven analysis [PDF]

arXiv, 2013
Motivation: Analysis of relationships of drug structure to biological response is key to understanding off-target and unexpected drug effects, and for developing hypotheses on how to tailor drug thera-pies. New methods are required for integrated analyses of a large number of chemical features of drugs against the corresponding genome-wide responses of
arxiv  

The influence of the perinatal environment on the heart: morphological, electrocardiographic, and multimodality imaging features

Journal of Pediatric and Neonatal Individualized Medicine, 2015
The purpose of this paper is to review the studies performed to evaluate the influence of perinatal environment on neonatal heart, detected by electrocardiography, echocardiography, and other imaging techniques.
Giuseppe Mercuro, Pier Paolo Bassareo
doaj   +1 more source

Withdrawal from treatment as an outcome in the Isolde study of COPD [PDF]

, 2003
Objectives: To investigate the determinants of patient withdrawal from our study, and the effect of these withdrawals on the outcome of treatment with inhaled corticosteroids in patients with COPD.
American Thoracic Society, Brazier, Burge, Chervinsky, Davies, Greening, Jarad, Jones, Jones, Jones, Jones, Lisa Willits, Meecham-Jones, Nelson, Niewoehner, Osman, P. Sherwood Burge, Paul W. Jones, Pauwels, Pauwels, Pauwels, Peter M.A. Calverley, Sally Spencer, Seemungal, Spencer, The Lung Health Study Research Group, Vestbo, Ware   +27 more
core   +1 more source

Comparative Efficacy of Inhaled and Intravenous Corticosteroids in Managing COVID-19-Related Acute Respiratory Distress Syndrome

Pharmaceutics
Acute respiratory distress syndrome (ARDS) is a life-threatening condition in which the lungs fail to provide sufficient oxygen to the body’s vital organs. It is commonly associated with COVID-19 patients. Severe cases of COVID-19 can lead to lung damage
Ahmed A. Abdelkader, Bshra A. Alsfouk, Asmaa Saleh, Mohamed E. A. Abdelrahim, Haitham Saeed   +4 more
doaj   +1 more source

Different Dosages of Corticosteroid and Routes of Administration in Mandibular Third Molar Surgery: a Systematic Review

eJournal of Oral Maxillofacial Research, 2018
Objectives: The objective of the present systematic review was to test the hypothesis of no difference in facial swelling, pain and trismus after surgical removal of mandibular third molar with different dosages of corticosteroids and administration ...
Marie Kjærgaard Larsen, Thomas Kofod, Ann-Eva Christiansen, Thomas Starch-Jensen   +3 more
doaj   +1 more source

The clinical management of hepatic sarcoidosis: A systematic review

JGH Open
Background Hepatic sarcoidosis is an uncommon clinical condition in which clear recommendations are lacking in its treatment. We aimed to review systematically the literature on hepatic sarcoidosis treatment to guide clinicians.
Ram Prasad Sinnanaidu, Vikneshwaran Chandra Kumar, Ranita Hisham Shunmugam, Sanjiv Mahadeva   +3 more
doaj   +1 more source

MARVEL: A Randomized Double‐Blind, Placebo‐Controlled Trial in Patients Undergoing Endovascular Therapy: Study Rationale and Design

Stroke: Vascular and Interventional Neurology
Background Steroids have pleiotropic neuroprotective actions including the regulation of inflammation and apoptosis which may influence the effects of ischemia on neurons, glial cells, and blood vessels.
Qingwu Yang, Changwei Guo, Chengsong Yue, Jie Yang, Linyu Li, Zhouzhou Peng, Jinrong Hu, Jiandi Huang, Jiaxing Song, Jiacheng Huang, Weilin Kong, Nizhen Yu, Dahong Yang, Xiang Liu, Duolao Wang, Raul G. Nogueira, Fengli Li, Thanh N. Nguyen, Wenjie Zi   +18 more
doaj   +1 more source

The Risk of Gout in Patients with Psoriasis: A Population-Based Cohort Study in Taiwan

Clinical Epidemiology, 2022
James Cheng-Chung Wei,1– 3 Yi-Jung Chang,4 Yu-Hsun Wang,5 Chih-Jung Yeh6 1Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan; 2Institute of Medicine, College of Medicine, Chung Shan Medical ...
Wei JCC, Chang YJ, Wang YH, Yeh CJ
doaj  

Institutional-Level Monitoring of Immune Checkpoint Inhibitor IrAEs Using a Novel Natural Language Processing Algorithmic Pipeline [PDF]

arXiv
Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but can result in severe immune-related adverse events (IrAEs). Monitoring IrAEs on a large scale is essential for personalized risk profiling and assisting in treatment decisions.
arxiv