Results 91 to 100 of about 424,197 (335)

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Diagnosis and treatment of canine hypoadrenocorticism [PDF]

, 2018
Canine hypoadrenocorticism (Addison’s disease), the ‘great pretender’ of internal medicine, is a disease that should be frequently considered as a differential diagnosis of several clinical presentations, albeit it is less commonly the actual cause of ...
Gunn, Eilidh, Ramsey, Ian, Spence, Susanna   +2 more
core   +1 more source

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

Redefining the Diagnostic Approach to Adrenal Insufficiency: Re-Assessment of Baseline and Cortisol Increment Cut-Offs with the 1 µg Synacthen Test

Medicina
Background and Objectives: Adrenal insufficiency (AI) is an endocrine disorder characterized by inadequate cortisol production, leading to non-specific symptoms that delay diagnosis. The Low Dose Synacthen Test (LDST) is commonly used to evaluate adrenal
Taieb Ach, Rim Dhaffar, Asma Ammar, Aycha Ghachem, Imen Halloul, Wiem Saafi, Hamza El Fekih, Ghada Saad, Yosra Hasni, Monia Zaouali   +9 more
doaj   +1 more source

Urine cortisol in pigs of different MH-genotypes

Acta Agriculturae Slovenica, 2003
Urine cortisol concentration was evaluated in German Landrace barrows of two MH-genotypes (NN, Nn) housed in metabolic cages. Furthermore, cortisol in urine was evaluated as a substitute measure of plasma cortisol values in pigs.
Nataša SIARD, Milena KOVAČ, Jan LADEWIG, Ivan ŠTUHEC   +3 more
doaj   +1 more source

Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults [PDF]

, 2006
Among younger adults, the ability to willfully regulate negative affect, enabling effective responses to stressful experiences, engages regions of prefrontal cortex (PFC) and the amygdala.
Alexander, Andrew L., Davidson, Richard J., Frye, Corrina J., Greischar, Lawrence L., Jackson, Cory A., Johnstone, Tom, Kalin, Ned H., Schaefer, Hillary S., Thurow, Marchell E., Urry, Heather L., Van Reekum, Carina Marije   +10 more
core   +2 more sources

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Ngā mea kōaro o ngā wā tamarikitanga, te taumahatanga o aua mea me ētahi mahi whakaora hinegaro mō ngā wāhine Māori = Adverse childhood experiences, HPA axis functioning and culturally enhanced mindfulness therapy among Māori women in Aotearoa New Zealand : a dissertation presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Psychology at Massey University, Palmerston North, New Zealand [PDF]

, 2019
Listed in 2019 Dean's List of Exceptional ThesesFigures 2.1 (p. 33), 2.2 (p. 38), 2.3 (p. 43), 3.1 (p. 58), 3.2 (p. 58) & 3.3 (p. 60) have been removed for copyright reasons but may be accessed via their sources listed in the References.Chronic health ...
Ketu-McKenzie, Miriama Deborah
core  

Investigation of the Relationship among Cortisol, Pro-inflammatoryCytokines, and the Degradation of Tryptophan into Kynurenine inPatients with Major Depression and Suicidal Behavior

, 2021
A. Messaoud, R. Mensi, Wahiba Douki, Fadoua Neffati, Mohamed Fadhel Najjar, Gabriella Gobbi, Mirko Manchia, Flavia Valtorta, Gaha Lotfi, Stefano Comai   +9 more
openalex   +2 more sources

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source