Results 1 to 10 of about 4,237 (98)
Optimizing recombineering in Corynebacterium glutamicum [PDF]
Biotechnology and Bioengineering, 2021 AbstractOwing to the increasing demand for amino acids and valuable commodities that can be produced by Corynebacterium glutamicum, there is a pressing need for new rapid genome engineering tools that improve the speed and efficiency of genomic insertions, deletions, and mutations.
Anthony J. Sinskey +7 more
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Physiological Response of Corynebacterium glutamicum to Indole [PDF]
Microorganisms, 2020 The aromatic heterocyclic compound indole is widely spread in nature. Due to its floral odor indole finds application in dairy, flavor, and fragrance products. Indole is an inter- and intracellular signaling molecule influencing cell division, sporulation, or virulence in some bacteria that synthesize it from tryptophan by tryptophanase ...
Walter, Tatjana +8 more
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Carotenoid biosynthesis and overproduction in Corynebacterium glutamicum [PDF]
BMC Microbiology, 2012 Abstract Background Corynebacterium glutamicum contains the glycosylated C50 carotenoid decaprenoxanthin as yellow pigment. Starting from isopentenyl pyrophosphate, which is generated in the non-mevalonate pathway, decaprenoxanthin is synthesized via the intermediates farnesyl pyrophosphate ...
Heider, Sabine +2 more
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Identifying the Growth Modulon of Corynebacterium glutamicum [PDF]
Frontiers in Microbiology, 2019 The growth rate (μ) of industrially relevant microbes, such as Corynebacterium glutamicum, is a fundamental property that indicates its production capacity. Therefore, understanding the mechanism underlying the growth rate is imperative for improving productivity and performance through metabolic engineering.
Thorsten Haas +8 more
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The DtxR Regulon ofCorynebacterium glutamicum [PDF]
Journal of Bacteriology, 2006 ABSTRACTPrevious studies withCorynebacterium diphtheriaeandMycobacteriumspecies revealed that the transcriptional regulator DtxR and its ortholog IdeR play a central role in the control of iron metabolism. In the present work, we used genome-based approaches to determine the DtxR regulon ofCorynebacterium glutamicum, a nonpathogenic relative ofC ...
Wennerhold, J., Bott, M.
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Evolutionary engineering of Corynebacterium glutamicum [PDF]
Biotechnology Journal, 2019 A unique feature of biotechnology is that we can harness the power of evolution to improve process performance. Rational engineering of microbial strains has led to the establishment of a variety of successful bioprocesses, but it is hampered by the overwhelming complexity of biological systems.
Stella, Roberto G. +3 more
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Engineering Corynebacterium glutamicum for isobutanol production [PDF]
Applied Microbiology and Biotechnology, 2010 The production of isobutanol in microorganisms has recently been achieved by harnessing the highly active 2-keto acid pathways. Since these 2-keto acids are precursors of amino acids, we aimed to construct an isobutanol production platform in Corynebacterium glutamicum, a well-known amino-acid-producing microorganism.
Smith, Kevin Michael +2 more
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Metabolic Engineering in Corynebacterium glutamicum
, 2020 Corynebacterium glutamicum strain development has adopted each metabolic engineering tool immediately upon its conception and has contributed to developing these tools further. In the last more than five decades, C. glutamicum strains have been selected and screened after undirected mutagenesis.
Wendisch, Volker F. +3 more
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Silencing of cryptic prophages inCorynebacterium glutamicum [PDF]
Nucleic Acids Research, 2016 DNA of viral origin represents a ubiquitous element of bacterial genomes. Its integration into host regulatory circuits is a pivotal driver of microbial evolution but requires the stringent regulation of phage gene activity. In this study, we describe the nucleoid-associated protein CgpS, which represents an essential protein functioning as a ...
Pfeifer, Eugen +6 more
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The Zur regulon of Corynebacterium glutamicum ATCC 13032 [PDF]
BMC Genomics, 2010 Abstract Background Zinc is considered as an essential element for all living organisms, but it can be toxic at large concentrations. Bacteria therefore tightly regulate zinc metabolism. The Cg2502 protein of Corynebacterium glutamicum was a candidate to control zinc metabolism in this species, since it was classified
Schröder, Jasmin +3 more
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