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Advances and Perspectives for Genome Editing Tools of Corynebacterium glutamicum

Frontiers in Microbiology, 2021
Corynebacterium glutamicum has been considered a promising synthetic biological platform for biomanufacturing and bioremediation. However, there are still some challenges in genetic manipulation of C. glutamicum.
Qingzhuo Wang, Jiao Zhang, Jiao Zhang, Naief H. Al Makishah, Xiaoman Sun, Zhiqiang Wen, Zhiqiang Wen, Yu Jiang, Sheng Yang, Sheng Yang   +9 more
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Eliminating the capsule-like layer to promote glucose uptake for hyaluronan production by engineered Corynebacterium glutamicum

Nature Communications, 2020
Bioproduction of hyaluronan needs increases in yield and greater diversity of the molecular weights. Here, the author increases hyaluronan production and diversifies the molecular weights through engineering the hyaluronan biosynthesis pathway and ...
Yang Wang, Litao Hu, Hao Huang, Hao Wang, Tianmeng Zhang, Jian Chen, Guocheng Du, Zhen Kang   +7 more
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Biosynthesis of eriodictyol from tyrosine by Corynebacterium glutamicum

Microbial Cell Factories, 2022
Background Eriodictyol is a bioactive flavonoid compound that shows potential applications in medicine development and food processing. Microbial synthesis of eriodictyol has been attracting increasing attention due to several benefits. In this study, we
Xia Wu, Jingyi Liu, Dan Liu, Miaomiao Yuwen, Mattheos A. G. Koffas, Jian Zha   +5 more
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Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum

Nature Communications, 2020
The regulation of higher-order chromosome folding and segregation in bacteria is poorly understood. Here, Böhm et al. provide insights into the roles of DNA partitioning protein ParB and SMC condensin complexes in Corynebacterium glutamicum.
Kati Böhm, Giacomo Giacomelli, Andreas Schmidt, Axel Imhof, Romain Koszul, Martial Marbouty, Marc Bramkamp   +6 more
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Efficient Multiplex Gene Repression by CRISPR-dCpf1 in Corynebacterium glutamicum

Frontiers in Bioengineering and Biotechnology, 2020
Corynebacterium glutamicum is an important workhorse for industrial production of diversiform bioproducts. Multiplex control of metabolic pathway genes is crucial for maximizing biosynthesis of desired products.
Mingyue Li, Mingyue Li, Jiuzhou Chen, Yu Wang, Jiao Liu, Jingwen Huang, Jingwen Huang, Ning Chen, Ping Zheng, Jibin Sun   +9 more
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CRISPR-Cpf1 assisted genome editing of Corynebacterium glutamicum

Nature Communications, 2017
Corynebacterium glutamicum is an important industrial microbe, however it has proven difficult to genetically engineer using Cas9 from Streptococcus pyogenes.
Yu Jiang, Fenghui Qian, Junjie Yang, Yingmiao Liu, Feng Dong, Chongmao Xu, Bingbing Sun, Biao Chen, Xiaoshu Xu, Yan Li, Renxiao Wang, Sheng Yang   +11 more
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Safety and efficacy of a feed additive consisting of L‐valine produced using Corynebacterium glutamicum KCCM 80366 for all animal species (CJ Europe GmbH) [PDF]

EFSA Journal, Volume 23, Issue 12, December 2025.
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of L‐valine produced by fermentation using the non‐genetically modified strain of Corynebacterium glutamicum KCCM 80366 as a nutritional feed additive for all animal species and categories.
Yolanda Sanz, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Fašmon Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto Maradona, Ilen Röhe, Katerina Theodoridou, Montserrat Anguita, Nicole Bozzi Cionci, Matteo L. Innocenti, Joana P. Firmino, Fabiola Pizzo, Orsolya Holczknecht, Joana Revez   +22 more
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Production of the Antimicrobial Roseoflavin With Genetically Engineered Corynebacterium glutamicum [PDF]

Microbial Biotechnology
The global rise of drug‐resistant bacterial infections underscores an urgent demand for novel antimicrobial agents. Roseoflavin, a naturally occurring riboflavin analog, has emerged as a promising candidate for drug development.
Luciana Fernandes Brito, Ane Bræin Aas, Rosa Jodalen Rudberg, Trygve Brautaset, Fernando Pérez‐García   +4 more
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Systems metabolic engineering of Corynebacterium glutamicum for efficient l-tryptophan production [PDF]

Synthetic and Systems Biotechnology
Corynebacterium glutamicum is a versatile industrial microorganism for producing various amino acids. However, there have been no reports of well-defined C. glutamicum strains capable of hyperproducing l-tryptophan.
Yufei Dong, Zhen Chen
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Review of the Proteomics and Metabolic Properties of Corynebacterium glutamicum. [PDF]

Microorganisms
Park J, Lim S.
europepmc   +2 more sources