Results 11 to 20 of about 50,342 (276)

3-Substituted Coumarins Inhibit NorA and MepA Efflux Pumps of Staphylococcus aureus

Antibiotics, 2023
Coumarins are compounds with scientifically proven antibacterial properties, and modifications to the chemical structure are known to improve their effects.
José B. de Araújo-Neto, Cícera D. de M. Oliveira-Tintino, Gildênia A. de Araújo, Daniel S. Alves, Fernanda R. Ribeiro, Guilherme A. Brancaglion, Diogo T. Carvalho, Clara Mariana Gonçalves Lima, Hani S. H. Mohammed Ali, Irfan A. Rather, Mohmmad Y. Wani, Talha B. Emran, Henrique D. M. Coutinho, Valdir de Q. Balbino, Saulo R. Tintino   +14 more
doaj   +1 more source

COSY catalyses trans-cis isomerization and lactonization in the biosynthesis of coumarins [PDF]

, 2019
Coumarins, also known as 1,2-benzopyrones, comprise a large class of secondary metabolites that are ubiquitously found throughout the plant kingdom.
Boerjan, Wout, De Meester, Barbara, Goeminne, Geert, Haustraete, Jurgen, Hoengenaert, Lennart, Kim, Hoon, Li, Jin, Liu, Xinyu, Morreel, Kris, Ralph, John, Schmidt, Wolfgang, Seetso, Carol, Sundin, Lisa, Tsai, Huei-Hsuan, Vanholme, Bartel, Vanholme, Ruben   +15 more
core   +1 more source

2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins

Frontiers in Plant Science, 2014
Coumarins are natural plant products that have been the subject of extensive phytochemical and pharmacological research studies in the past few decades.
Bun-Ichi eShimizu
doaj   +1 more source

Structure–Activity Analysis and Molecular Docking Studies of Coumarins from Toddalia asiatica as Multifunctional Agents for Alzheimer’s Disease

Biomedicines, 2020
Coumarins, naturally occurring phytochemicals, display a wide spectrum of biological activities by acting on multiple targets. Herein, nine coumarins from the root of Toddalia asiatica were evaluated for activities related to pathogenesis of Alzheimer’s ...
Pitchayakarn Takomthong, Pornthip Waiwut, Chavi Yenjai, Bungon Sripanidkulchai, Prasert Reubroycharoen, Ren Lai, Peter Kamau, Chantana Boonyarat   +7 more
doaj   +1 more source

Down-regulatory mechanism of mammea E/BB from Mammea siamensis seed extract on Wilms' Tumor 1 expression in K562 cells. [PDF]

, 2016
BackgroundWilms' tumor 1 (WT1) is a biological marker for predicting leukemia progression. In this study, mammea E/BB, an active compound from Saraphi (Mammea siamensis) seed extract was examined for its effect on down-regulatory mechanism of WT1 gene ...
Ampasavate, Chadarat, Anuchapreeda, Songyot, Katekunlaphan, Trinnakorn, Okonogi, Siriporn, Rungrojsakul, Methee, Saiai, Aroonchai, Sweeney, Colleen A   +6 more
core   +1 more source

Methyl 2-oxo-2H-chromene-3-carboxylate [PDF]

, 2012
The title compound, C11H8O4, features an almost planar molecule (r.m.s. deviation = 0.033 Å for all non-H atoms). In the crystal, the molecules are linked via C-H...O hydrogen bonds, forming two-dimensional networks lying parallel to (1-21)
Arshad, Muhammad, Bolte, Michael, Ibrar, Aalia, Saeed, Aamer   +3 more
core   +2 more sources

Safety Profile of Nutraceuticals Rich in Coumarins: An Update

Frontiers in Pharmacology, 2022
Coumarins are a family of benzopyrones largely distributed in the natural kingdom, being present in the seeds, fruits, flowers, or roots of various plant species.
Simona Codruta Heghes, Oliviu Vostinaru, Cristina Mogosan, Doina Miere, Cristina Adela Iuga, Cristina Adela Iuga, Lorena Filip   +6 more
doaj   +1 more source

Auraptene Promotes THP-1 Polarization to M1 Macrophages and Improves M1 Function [PDF]

Research Journal of Pharmacognosy, 2022
Background and Objectives: Macrophages play an important role in tumor growth (M2 macrophage) or suppression (M1 macrophage). Auraptene, a prenyloxycoumarin compound extracted from Citrus plants, has anti-cancer and anti-inflammatory properties.
Afshin Jalali, Mostafa Haji Molla Hoseini, Mitra Rezaei, Seyed Ali Ziai*   +3 more
doaj   +1 more source

Isolation, spectroscopic characterization, X-ray, theoretical studies as well as in vitro cytotoxicity of Samarcandin [PDF]

, 2016
Samarcandin 1, a natural sesquiterpene-coumarin, was isolated as well as elucidated from F. assa-foetida which has significant effect in Iranian traditional medicine because of its medicinal attitudes.
Atabaki, V., Babaei, E., Dusek, M., Eigner, V., Ghoran, S.H., Khalaji, A.D., Olfatkhah, S.R., Soltani, A.   +7 more
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Antagonists of Vitamin K—Popular Coumarin Drugs and New Synthetic and Natural Coumarin Derivatives

Molecules, 2020
Many natural coumarins and their chemically synthesized analogs and derivatives exert diverse properties, such as anticancer, antioxidant, anti-inflammatory, or anticoagulant, with the latter being of the utmost importance.
Kinga Kasperkiewicz, Michał B. Ponczek, Jacek Owczarek, Piotr Guga, Elżbieta Budzisz   +4 more
doaj   +1 more source