Results 41 to 50 of about 2,847,915 (169)

Mechanisms of Hepatitis B Virus cccDNA and Minichromosome Formation and HBV Gene Transcription

Viruses
Hepatitis B virus (HBV) is the etiologic agent of chronic hepatitis B, which puts at least 300 million patients at risk of developing fibrosis, cirrhosis, and hepatocellular carcinoma.
Andoni Gómez-Moreno, Alexander Ploss
doaj   +1 more source

Intrahepatic HBV DNA and covalently closed circular DNA (cccDNA) levels of patients with positive anti-HBc antibody and negative HBsAg [PDF]

วิทยานิพนธ์ (วท.ม.)--จุฬาลงกรณ์มหาวิทยาลัย, 2550ความสำคัญและที่มาของปัญหางานวิจัย ซีซีซีดีเอ็นเอเป็นส่วนที่มีบทบาทสำคัญของไวรัสตับอักเสบบีที่ทำให้เกิดการคงอยู่ของเชื้อไวรัสในตับเป็นเวลานาน และทำให้เกิดการถ่ายทอดเชื้อผ่านทางการปลูกถ่ายอวัยวะ รวมถึงทำให้เกิ
รุ่งฤดี ชัยธีรกิจ
core   +1 more source

Replication-driven HBV cccDNA loss in chimeric mice with humanized livers

Journal of Virology
Hepatitis B virus (HBV) infection depends on the establishment of covalently closed circular DNA (cccDNA) and can be either transient or persistent. Persistent infection requires a noncytopathic viral phenotype, primarily achieved by limiting replication
Bai-Hua Zhang, Yuanping Zhou, Stephen Horrigan, Fabien Zoulim, Jianming Hu, Yong-Yuan Zhang   +5 more
doaj   +1 more source

Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus.

PLoS Pathogens, 2018
Hepatitis B virus (HBV) is one of the major etiological pathogens for liver cirrhosis and hepatocellular carcinoma. Chronic HBV infection is a key factor in these severe liver diseases.
Kouichi Kitamura, Lusheng Que, Miyuki Shimadu, Miki Koura, Yuuki Ishihara, Kousho Wakae, Takashi Nakamura, Koichi Watashi, Takaji Wakita, Masamichi Muramatsu   +9 more
doaj   +1 more source

Advances in Viral Markers for Predicting Functional Cure of Chronic Hepatitis B

Portal Hypertension &Cirrhosis, EarlyView.
Functional cure, defined as sustained hepatitis B surface antigen (HBsAg) loss, is achieved by only a minority of patients with chronic hepatitis B (CHB); early identification of likely responders may improve cure rates and reduce costs. However, responses to antiviral therapy vary considerably, necessitating reliable hepatitis B virus (HBV) viral ...
Xinrong Lu, Xin Yang, Qishui Ou, Zhen Xun   +3 more
wiley   +1 more source

Quantitation of HBV covalently closed circular DNA (HBV CCC DNA) in HCC patients

, 2004
Objective: Hepatitis B virus (HBV) is a major causative agent of hepatocellular carcinoma (HCC). We aimed to use the Invader assay to measure the intrahepatic total HBV DNA and covalently closed circular (ccc) DNA in the tumorous and non-tumorous ...
Poon, RTP, Yuen, RMF, Sum, SM, Lai, CL, Wong, DKH   +4 more
core   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Circular DNA's from HeLa cell nuclei and mitochondria [PDF]

, 1970
An electron microscopic observation was made on the DNA's extracted from purified HeLa cell nuclei, mitochondria, and the whole cell, and fractionated by ethidium bromide-cesium chloride density gradient method or sucrose density gradient method. Nuclear
Oda, Takuzo, Yamamoto, Shinichiro, Hirata, Seiichi, Nishida, Shigeru, Omura, Sachiko   +4 more
core   +1 more source

Hepatitis B in Organ Transplantation—Current Evidence and Clinical Gaps

Transplant Infectious Disease, EarlyView.
ABSTRACT Over the past several decades there have been significant advances in nucleos(t)ide analogue (NA) antiviral therapy for hepatitis B virus (HBV) and global expansion of primary prevention through immunization. Despite this, HBV remains a leading cause of chronic liver disease globally, affecting over 250 million people.
Oscar A. Fernandez‐Garcia, Britta L. Hirsch, Irene A. Abela, Karen E. Doucette   +3 more
wiley   +1 more source

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis

Life Science Alliance, 2019
Our study highlights a dual role for SAMHD1 in regulating hepatitis B virus cccDNA levels and reverse transcriptase–dependent particle genesis. Chronic hepatitis B is one of the world’s unconquered diseases with more than 240 million infected subjects at
Peter AC Wing, Tamara Davenne, Jochen Wettengel, Alvina G Lai, Xiaodong Zhuang, Anindita Chakraborty, Valentina D’Arienzo, Catharina Kramer, Chunkyu Ko, James M Harris, Sabrina Schreiner, Martin Higgs, Stephanie Roessler, Joanna L Parish, Ulrike Protzer, Peter Balfe, Jan Rehwinkel, Jane A McKeating   +17 more
doaj   +1 more source