Results 21 to 30 of about 2,847,915 (169)
Molecular Therapy: Nucleic Acids, 2023 CRISPR-Cas9 systems can directly target the hepatitis B virus (HBV) major genomic form, covalently closed circular DNA (cccDNA), for decay and demonstrate remarkable anti-HBV activity.
Dmitry Kostyushev +19 more
doaj +1 more source
Gene Editing Technologies to Target HBV cccDNA
Viruses, 2022 Hepatitis B virus (HBV) remains a significant cause of mortality and morbidity worldwide, since chronic HBV infection is associated with elevated risk of cirrhosis and hepatocellular carcinoma.
Maria Guadalupe Martinez +5 more
doaj +1 more source
Duck Hepatitis B Virus cccDNA Amplification Efficiency in Natural Infection Is Regulated by Virus Secretion Efficiency. [PDF]
PLoS ONE, 2015 Previous mutation based studies showed that ablating synthesis of viral envelope proteins led to elevated hepadnaviral covalently closed circular DNA (cccDNA) amplification, but it remains unknown how cccDNA amplification is regulated in natural ...
Yong-Yuan Zhang
doaj +1 more source
Annals of Hepatology, 2020 Introduction and objectives: HBV covalently closed circular (ccc) DNA is the key player in viral persistence and an important predictive biomarker for hepatitis relapse.
Ching-Yu Bao +5 more
doaj +1 more source
Research progress in hepatitis B virus covalently closed circular DNA
Cancer Biology & Medicine, 2022 Hepatitis B virus (HBV) infections are a global public health issue. HBV covalently closed circular DNA (cccDNA), the template for the transcription of viral RNAs, is a key factor in the HBV replication cycle.
Xiaodong Zhang, Yufei Wang, Guang Yang
doaj +1 more source
Application of anti-HBc quantitative examination in clinical management of chronic hepatitis B virus infection [PDF]
Jichu yixue yu linchuang, 2022 The quantification of hepatitis B virus(HBV) core antibody (anti-HBc) is related to host immunity and can be detected in the serum of patients with current or past infections.
DU Xin-yi, MAO Xiao-rong, LI Jun-feng
doaj +1 more source
Proteomic Analysis of Nuclear Hepatitis B Virus Relaxed Circular DNA-Associated Proteins Identifies UV-Damaged DNA Binding Protein as a Host Factor Involved in Covalently Closed Circular DNA Formation [PDF]
, 2022 Hepatitis B virus (HBV) utilizes host DNA repair mechanisms to convert viral relaxed circular DNA (rcDNA) into a persistent viral genome, the covalently closed circular DNA (cccDNA).
Yu, Xiaoyang +6 more
core +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Occult hepatitis B virus (HBV) infection (OBI) is a condition in which replication-competent viral DNA is detected in the liver (with detectable or undetectable HBV DNA in serum) of individual testing negative for HBV surface antigen (HBsAg).
Chengwei Wang +4 more
doaj +1 more source
Approaches to quantifying hepatitis B virus covalently closed circular DNA [PDF]
Clinical and Molecular Hepatology, 2022 Chronic hepatitis B is a major cause of liver disease worldwide and is currently incurable. Hepatitis B virus (HBV) covalently closed circular (ccc) DNA is a key form of the virus responsible for its persistence and is the transcriptional template for ...
Henrik Zhang, Thomas Tu
doaj +1 more source
Вопросы вирусологии, 2018 Chronic hepatitis B is caused by a persistent form of hepatitis B virus, covalently closed circular DNA (cccDNA). Stability of cccDNA is associated with intracellular localization of cccDNA and formation of minichromosome, regulated by epigenetic ...
D. S. Kostyushev +6 more
doaj +1 more source