Results 11 to 20 of about 2,847,915 (169)
The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation. [PDF]
PLoS Pathogens, 2017 Hepadnavirus covalently closed circular (ccc) DNA is the bona fide viral transcription template, which plays a pivotal role in viral infection and persistence.
Quanxin Long +11 more
doaj +2 more sources
PLoS Pathogens, 2019 Persistent hepatitis B virus (HBV) infection relies on the establishment and maintenance of covalently closed circular (ccc) DNA, a 3.2 kb episome that serves as a viral transcription template, in the nucleus of an infected hepatocyte.
Liudi Tang +4 more
doaj +2 more sources
Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner. [PDF]
PLoS Pathogens, 2010 Persistence of hepatitis B virus (HBV) infection requires covalently closed circular (ccc)DNA formation and amplification, which can occur via intracellular recycling of the viral polymerase-linked relaxed circular (rc) DNA genomes present in virions ...
Josef Köck +5 more
doaj +2 more sources
Characterization of the host factors required for hepadnavirus covalently closed circular (ccc) DNA formation. [PDF]
PLoS ONE, 2012 Synthesis of the covalently closed circular (ccc) DNA is a critical, but not well-understood step in the life cycle of hepadnaviruses. Our previous studies favor a model that removal of genome-linked viral DNA polymerase occurs in the cytoplasm and the ...
Haitao Guo +4 more
doaj +2 more sources
Differences in sequences between HBV-relaxed circular DNA and covalently closed circular DNA
Emerging Microbes and Infections, 2017 The hepatitis B virus (HBV) genome exists in two forms: circular covalently closed DNA (cccDNA) and relaxed circular DNA (RCDNA). Here, we investigated the presence of differences in the sequences of both forms in paired samples of serum and liver tissue.
Magda Rybicka +5 more
doaj +2 more sources
Transcription of hepatitis B virus covalently closed circular DNA is regulated by CpG methylation during chronic infection. [PDF]
PLoS ONE, 2014 The persistence of hepatitis B virus (HBV) infection is maintained by the nuclear viral covalently closed circular DNA (cccDNA), which serves as transcription template for viral mRNAs. Previous studies suggested that cccDNA contains methylation-prone CpG
Yongmei Zhang +12 more
doaj +2 more sources
PLoS Pathogens, 2016 Hepatitis B virus (HBV) infection of hepatocytes begins by binding to its cellular receptor sodium taurocholate cotransporting polypeptide (NTCP), followed by the internalization of viral nucleocapsid into the cytoplasm.
Yonghe Qi +14 more
doaj +2 more sources
Genes and DiseasesHuman hepatitis B virus (HBV) infection is the major cause of acute and chronic hepatitis B, liver cirrhosis, and hepatocellular carcinoma. Although the application of prophylactic vaccination programs has successfully prevented the trend of increasing ...
Jihua Ren +8 more
doaj +2 more sources
Functionally cured chronic hepatitis B: A cure-related occult HBV infection state. [PDF]
mLifeAbstract Occult HBV infection (OBI) is characterized by the presence of replication‐competent hepatitis B virus (HBV) DNA (covalently closed circular DNA [cccDNA] and/or relaxed circular DNA [rcDNA]) in the liver and/or HBV DNA in the blood, despite negative hepatitis B surface antigen (HBsAg) serology.
Lu F +6 more
europepmc +2 more sources
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source