Results 31 to 40 of about 2,847,915 (169)
Effect of nucleos(t)ide analogues therapy on HBsAg, intrahepatic HBV DNA and covalently closed circular DNA levels [PDF]
, 2012 BACKGROUND: We aimed to study 1) the effects of 1-year nucleos(t)ide analogue (NA) therapy on HBsAg and covalently closed circular DNA (cccDNA) levels; and 2) the possible use of HBsAg reduction as a marker for cccDNA reduction. METHODS: We recruited 124
Fung, J +5 more
core +1 more source
Host Transcription Factors in Hepatitis B Virus RNA Synthesis
Viruses, 2020 The hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one of the leading causes of liver cancer and hepatocellular carcinoma.
Kristi L. Turton +4 more
doaj +1 more source
PCR mediated recombination impacts the analysis of hepatitis B Virus covalently closed circular DNA [PDF]
, 2016 International audienceBackground: The replication of HBV involves the production of covalently closed circular DNA (cccDNA) from the HBV genome through the repair of virion relaxed circular DNA (rcDNA) in the virion.
Vartanian, Jean Pierre +7 more
core +1 more source
Covalently closed circular DNA: The ultimate therapeutic target for curing HBV infections
, 2021 Current antiviral therapies, such as pegylated interferon-α and nucleos(t)ide analogues, effectively improve the quality of life of patients with chronic hepatitis B.
Boyd, Anders +4 more
core +1 more source
, 2021 New antiviral therapies against hepatitis B virus (HBV) focus on the elimination of covalently closed circular DNA (cccDNA). However, traditional cccDNA-specific quantitative PCR (qPCR) has a narrow effective range, hindering a reliable comparison ...
Ming-Wei Lai +6 more
core +1 more source
Bio-Protocol, 2021 Hepatitis B virus (HBV) is the major cause of liver diseases and liver cancer worldwide. After infecting hepatocytes, the virus establishes a stable episome (covalently closed circular DNA, or cccDNA) that serves as the template for all viral transcripts.
Benno Zehnder, Stephan Urban, Thomas Tu
doaj +1 more source
Concerted action of activation-induced cytidine deaminase and uracil-DNA glycosylase reduces covalently closed circular DNA of duck hepatitis B virus [PDF]
, 2013 Covalently closed circular DNA (cccDNA) forms a template for the replication of hepatitis B virus (HBV) and duck HBV (DHBV). Recent studies suggest that activation-induced cytidine deaminase (AID) functions in innate immunity, although its molecular ...
Chowdhury, Sajeda +11 more
core +1 more source
IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome. [PDF]
PLoS ONE, 2015 The HBV covalently closed circular DNA (cccDNA) is organized as a mini-chromosome in the nuclei of infected hepatocytes by histone and non-histone proteins.
Gianna Aurora Palumbo +10 more
doaj +1 more source
Mechanism of Hepatitis B Virus cccDNA Formation
Viruses, 2021 Hepatitis B virus (HBV) remains a major medical problem affecting at least 257 million chronically infected patients who are at risk of developing serious, frequently fatal liver diseases.
Lei Wei, Alexander Ploss
doaj +1 more source
Detection of HBV Covalently Closed Circular DNA
, 2017 Chronic hepatitis B virus (HBV) infection affects approximately 240 million people worldwide and remains a serious public health concern because its complete cure is impossible with current treatments.
Xiaoling Li +3 more
core +1 more source