Results 131 to 140 of about 231,281 (308)

Tunable‐Threshold UV Dosimetry With Programmable Luminescent Tags via Oxygen‐Mediated Room‐Temperature Phosphorescence

Advanced Materials Technologies, EarlyView.
A fully organic UV threshold dosimeter is developed by exploiting the oxygen‐sensitive room‐temperature phosphorescence of a purely organic emitter in a polymer matrix. Upon reaching a specific cumulative UV dose, photochemical oxygen depletion triggers a sharp, high‐contrast emission.
Tim Achenbach, Paul‐Anton Will, Karl Sebastian Schellhammer, Sebastian Reineke   +3 more
wiley   +1 more source

COVID-19 guide for drug and alcohol residential rehab and detox services.

, 2020
What is a residential rehabilitation or detoxification service? Residential rehabilitation services and detoxification services for people tackling drug and alcohol dependence operate very differently from traditional care settings.

core  

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study

, 2020
Background To date, few data on paediatric COVID-19 have been published, and most reports originate from China. This study aimed to capture key data on children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection ...
Wagner, Noémie, Heininger, Ulrich, Christiaens, Christelle, Biebl, Ariane, Pierantoni, Luca, Bernar, Benoît, Noguera-Julián, Antoni, Lancella, Laura, Soriano-Arandes, Antoni, Krivec, Uros, Lanaspa, Miguel, Gabrovska, Natalia, Shingadia, Delane, Debulpaep, Sara, Santiago-García, Begoña, Song, Rinn, Thir, Christina, Buonsenso, Danilo, Bogyi, Matthias, Kohlfürst, Daniela S, Velizarova, Svetlana, Welch, Steven B, L'Huillier, Arnaud G, Bael, An, Roglić, Srđan, Pfefferle, Jasmin, Lo Vecchio, Andrea, Santos, Mar, Van Brusselen, Daan, Zschocke, Anna, Strenger, Volker, Brinkmann, Folke, Bandi, Srini, Haberlandt, Edda, Boiy, Tine, Berger, Angelika, Simma, Burkhard, Lanari, Marcello, Creuven, Marine, Götzinger, Florian, Melendo, Susana, Prunk, Petra, Calò Carducci, Francesca I, Berger, Roland, Osterman, Veronika, Schelstraete, Petra, Ritz, Nicole, Zacharasiewicz, Angela, Tebruegge, Marc, Vanden Driessche, Koen, Krajcar, Nina   +50 more
core   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Native Hawaiian/Pacific Islander alcohol, tobacco and other drug use, mental health and treatment need in the United States during COVID‐19

, 2022
INTRODUCTION: Before COVID-19, Native Hawaiians/Pacific Islanders (NH/PI) endured a heavy burden of alcohol, tobacco and other drug (ATOD) use in prior US data.
Scott K. Okamoto, Erick G. Guerrero, Moss, Howard B., Guerrero, Erick G, Li‐Tzy Wu, Aitaoto, Nia, Subica, Andrew M, Andrew M. Subica, Martin, Tammy KK, Okamoto, Scott K, Guerrero, Erick G., Nia Aitaoto, Tammy K. K. Martin, Morey, Brittany N., Brittany N. Morey, Martin, Tammy K. K., Wu, Li‐Tzy, Wu, Li-Tzy, Subica, Andrew M., Morey, Brittany N, Moss, Howard B, Howard B. Moss, Okamoto, Scott K.   +22 more
core   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source