Results 211 to 220 of about 299,239 (347)

Bayesian Model Infers Drug Repurposing Candidates for Treatment of COVID-19

, 2021
Michael A. Kiebish, Punit Shah, Rangaprasad Sarangarajan, Vivek K. Vishnudas, Stéphane Gesta, Poornima K. Tekumalla, C. Bountra, Elder Granger, Eric E. Schadt, Leonardo O. Rodrigues, Niven R. Narain   +10 more
openalex   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Engineered Dual‐Function Antibody‐Like Proteins to Combat SARS‐CoV‐2‐Induced Immune Dysregulation and Inflammation

Advanced Science, EarlyView.
Engineered antibody‐like proteins block the SARS‐CoV‐2 spike protein from binding to host receptors and suppress immune overactivation through an MBL‐based scaffold. These dual‐function proteins effectively alleviate inflammation, complement activation, and lung injury, offering a promising therapeutic strategy against severe COVID‐19 and its ...
Yizhuo Wang, Chenwu Bai, Kerui Hou, Zhen Zhang, Ming Guo, Xin Wang, Fan Yang, Xin Liu   +7 more
wiley   +1 more source

Comparing the efficacy of anti□infectious drugs for the treatment of mild to severe COVID-19 patients: a protocol for a systematic review and network meta-analysis of randomized clinical trials

, 2021
Dejene Tolossa Debela, Kidist Digamo Heraro   +1 more
openalex   +1 more source

Recommendations for the treatment of multiple sclerosis with disease-modifying drugs during the COVID-19 pandemic

, 2020
R. Kizlaitienė, N. Giedraitienė, Ieva Sereikė, Justina Liutkienė, L. Leščinskienė, Gintaras Kaubrys   +5 more
openalex   +2 more sources

ESCMID COVID-19 living guidelines: drug treatment and clinical management

, 2021
Michele Bartoletti, Özlem Kurt Azap, Aleksandra Barać, Linda Bussini, Önder Ergönül, Robert Krause, José Ramón Paño‐Pardo, Nicholas Power, Marcella Sibani, Bálint Gergely Szabó, Sotirios Tsiodras, Paul E. Verweij, Ines Zollner‐Schwetz, Jesús Rodríguez‐Baño   +13 more
openalex   +1 more source

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

Advanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo, Xiang Wang, Yu‐Pei Liao, Andre E. Nel   +3 more
wiley   +1 more source

Potential Docking Affinity of Three Approved Drugs Against SARS-CoV-2 for COVID-19 Treatment

, 2020
Venkata Rachakulla, Hemanjali Rachakulla
openalex   +1 more source

The Relevance of Bioinformatics Applications in the Discovery of Vaccine Candidates and Potential Drugs for COVID-19 Treatment

, 2021
Onyeka S. Chukwudozie, C. Vincent, Charlotte Ndiribe, Abdullahi Tunde Aborode, Victor O. Oyebanji, Benjamin Obukowho Emikpe   +5 more
openalex   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source