Results 71 to 80 of about 13,629 (283)

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Wise Blood: The Principle of Overcoming in Disease and Immunity (Part 1) [PDF]

, 2020
The immune system is an intelligently made system designed for interaction with microbes even in a perfect world; it is more than a defense. However, in a post-fall world, it is primarily a body’s defense system.
Gillen, Alan L., Huy, Keoprommony
core   +1 more source

Structural conservation and functional diversity of the Poxvirus Immune Evasion (PIE) domain superfamily [PDF]

, 2015
Poxviruses encode a broad array of proteins that serve to undermine host immune defenses. Structural analysis of four of these seemingly unrelated proteins revealed the recurrent use of a conserved beta-sandwich fold that has not been observed in any ...
Alcami, Alejo, Altekar, Altschul, Baker, Buatois, Bursill, Byun, Christopher Nelson, Clark, Dabbagh, Daved Fremont, Deane, Finn, Graham, Hendrickson, Hnatiuk, Jabari Elliott, Kelley, Kelley, Lalani, Lateef, Lateef, Lee, Lin, Loparev, McCoy, Megan Epperson, Ng, Pelham, Reading, Rozwarski, Ruiz-Arguello, Seet, Silverman, Smith, Sukrit Singh, Upton, Werden, White, Wilkins   +40 more
core   +3 more sources

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Global ubiquitination analysis reveals extensive modification and proteasomal degradation of cowpox virus proteins, but preservation of viral cores

Scientific Reports, 2018
The emergence of Variola virus-like viruses by natural evolution of zoonotic Orthopoxviruses, like Cowpox virus (CPXV), is a global health threat. The proteasome is essential for poxvirus replication, making the viral components interacting with the ...
Marica Grossegesse, J. Doellinger, Annemarie Fritsch, M. Laue, J. Piesker, L. Schaade, A. Nitsche   +6 more
semanticscholar   +1 more source

Proliferative and neoplastic aural pinna masses in a collection of African giant pouched rats (Cricetomys ansorgei)

Veterinary Record Case Reports, EarlyView.
Abstract This case series describes aural lesions occurring in five African giant pouched rats (Cricetomys ansorgei) residing at a single zoological institution in southern California. Age of onset ranged from 3 to 7 years. Lesions occurred as single or multiple masses on one or both ears. A single case also developed a nasal mass.
Amanda Burke, Alison Righton, Tess Rooney, Matt Marinkovich, Garrett Fraess   +4 more
wiley   +1 more source

Decision and Discovery in Defining “Disease” [PDF]

, 2007
This version (May 17, 2005) was published in its final form as: Schwartz PH. Decision and discovery in defining 'disease'. In: Kincaid H, McKitrick J, editors.
B Gert, C Boorse, C Culver, C Rosenberg, E Rosch, G Ebbs, H Engelhardt, H Putnam, J Dupre, JC Wakefield, K Neander, K Sadegh-Zadeh, KA Richman, KS Donnellan, L King, L Reznek, L Wittgenstein, M J Konner, PH Schwartz, R Carnap, R G Millikan, T Lewens, W Ramsey, WVO Quine, ——, ——   +25 more
core   +2 more sources

Zoonotic Virus Seroprevalence among Bank Voles, Poland, 2002–2010

Emerging Infectious Diseases, 2019
Bank voles in Poland are reservoirs of zoonotic viruses. To determine seroprevalence of hantavirus, arenavirus, and cowpox virus and factors affecting seroprevalence, we screened for antibodies against these viruses over 9 years.
Maciej Grzybek, Tarja Sironen, Sanna Mäki, Katarzyna Tołkacz, Mohammed Alsarraf, Aneta Strachecka, Jerzy Paleolog, Beata Biernat, Kaludiusz Szczepaniak, Jolanta Behnke-Borowczyk, Antti Vaheri, Heikki Henttonen, Jerzy M. Behnke, Anna Bajer   +13 more
doaj   +1 more source

Here, There, and Everywhere: The Wide Host Range and Geographic Distribution of Zoonotic Orthopoxviruses

Viruses, 2020
The global emergence of zoonotic viruses, including poxviruses, poses one of the greatest threats to human and animal health. Forty years after the eradication of smallpox, emerging zoonotic orthopoxviruses, such as monkeypox, cowpox, and vaccinia ...
Natalia Ingrid Oliveira Silva, Jaqueline Silva de Oliveira, Erna Geessien Kroon, Giliane de Souza Trindade, Betânia Paiva Drumond   +4 more
doaj   +1 more source

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, EarlyView.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source