Results 71 to 80 of about 12,038 (266)

Here, There, and Everywhere: The Wide Host Range and Geographic Distribution of Zoonotic Orthopoxviruses

open access: yesViruses, 2020
The global emergence of zoonotic viruses, including poxviruses, poses one of the greatest threats to human and animal health. Forty years after the eradication of smallpox, emerging zoonotic orthopoxviruses, such as monkeypox, cowpox, and vaccinia ...
Natalia Ingrid Oliveira Silva   +4 more
doaj   +1 more source

Organelle Sorting and Proteomic Analysis to Identify Proteins Involved in the Uptake and Intracellular Trafficking of Nanoparticles

open access: yesSmall Methods, EarlyView.
A new method to identify proteins involved in the uptake and intracellular trafficking of nanoparticles is presented. After nanoparticle uptake, cells are lysed and the organelles with nanoparticles are purified using fluorescence assisted cell sorting. Next, their composition is determined by proteomic analysis.
Hector Garcia Romeu, Anna Salvati
wiley   +1 more source

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Non-Human Primate Models of Orthopoxvirus Infections

open access: yesVeterinary Sciences, 2014
Smallpox, one of the most destructive diseases, has been successfully eradicated through a worldwide vaccination campaign. Since immunization programs have been stopped, the number of people with vaccinia virus induced immunity is declining.
Anne Schmitt   +2 more
doaj   +1 more source

Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]

open access: yes, 2011
VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward   +1 more
core   +1 more source

Dairy production practices and associated risks for bovine vaccinia exposure in cattle, Brazil

open access: yesNew Microbes and New Infections, 2017
A cross-sectional serosurvey was performed to identify environmental features or practices of dairy farms associated with risk for exposure to vaccinia-like viruses in dairy cattle in Brazil.
I.A. Borges   +10 more
doaj   +1 more source

Spatial analyses of wildlife contact networks [PDF]

open access: yes, 2015
We thank Kathy Horadam for useful discussions about the graph dissimilarity measures and Meggan Craft for reading an early draft of the manuscript and for her helpful advice and encouragement.Peer reviewedPublisher ...
Abbasi, Babak   +4 more
core   +1 more source

Mpox and the Ethics of Outbreak Management: Lessons for Future Public Health Crises

open access: yesDeveloping World Bioethics, EarlyView.
ABSTRACT Mpox, first identified in captive monkeys in 1958 and recognized in humans by 1970 in the Democratic Republic of Congo, was historically confined to sporadic zoonotic outbreaks in Central and West Africa. These outbreaks, often driven by rodent‐to‐human transmission in resource‐limited settings, reflect persistent systemic health disparities ...
Adetayo E. Obasa   +3 more
wiley   +1 more source

Genome signatures, self-organizing maps and higher order phylogenies: a parametric analysis [PDF]

open access: yes, 2007
Genome signatures are data vectors derived from the compositional statistics of DNA. The self-organizing map (SOM) is a neural network method for the conceptualisation of relationships within complex data, such as genome signatures.
Gatherer, Derek
core   +4 more sources

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