Results 91 to 100 of about 10,225 (252)
LAG‐3+ regulatory T cells suppress the effector but not the proliferative response of naïve cognate antigen‐specific CD4+ T cells in vivo. The suppressed T cells display upregulation of immune checkpoints and downregulation of pro‐inflammatory pathways with enhanced TCR signaling and reduced oxidative metabolism.
Avijit Dutta +7 more
wiley +1 more source
Sir Matthew Tierney and the foundation of the 1804 Sussex Vaccine Institution [PDF]
Irish physician Sir Matthew John Tierney (1776–1845) was a vaccine pioneer who learnt the procedure directly from Edward Jenner in Gloucestershire. In 1802 Tierney completed an MD at Glasgow on vaccination and moved to Brighton, where he was appointed ...
Cooper, Maxwell +2 more
core +1 more source
A deep learning framework called MolVisGNN is proposed to fuse 3D molecular visual information of drugs with multi‐source features, which proves the importance of 3D molecular visual information of drugs and the advancedness of this model in the field of drug discovery, and provides a reference for how to more comprehensively express small molecule ...
Zimai Zhang +9 more
wiley +1 more source
Vaccine Delivery Methods into the Future [PDF]
Special Issue: Vaccine ...
Apostolopoulos, Vasso
core +2 more sources
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen +5 more
wiley +1 more source
Monkeypox Virus: Epidemiology, Virology, Diagnosis, Vaccine, and Therapeutics
This review provides a comprehensive overview of the latest research advances in MPXV, with a focused analysis across five core dimensions: epidemiology, virology, diagnosis, vaccine, and therapeutics. The primary objective of this review is to advance the understanding of MPXV and facilitate the development of more effective diagnostic methods ...
Yunzheng Yan +14 more
wiley +1 more source
Transmission from pet rats and cats to humans as well as severe infection in felids and other animal species have recently drawn increasing attention to cowpox virus (CPXV).
Roth Swaantje J +5 more
doaj +1 more source
Synthesizing current knowledge on the ecology, phenology, and cultivation of Vaccinium membranaceum
More than 100 edible native berries grow across Canada's vast territory and are used by over 600 Indigenous Peoples of Canada as a main component of their diet. This research provides critical insights into the ecology, phenology, and cultivation of black huckleberry (Vaccinium membranaceum), a species of significant ecological and cultural importance ...
Mehdi Sharifi +12 more
wiley +1 more source
Reconsidering the Argument from Underconsideration [PDF]
According to the argument from underconsideration, since theory evaluation is comparative, and since scientists do not have good reasons to believe that they are epistemically privileged, it is unlikely that our best theories are true.
Mizrahi, Moti
core
Are all hosts created equal? Partitioning host species contributions to parasite persistence in multihost communities [PDF]
Many parasites circulate endemically within communities of multiple host species. To understand disease persistence within these communities, it is essential to know the contribution each host species makes to parasite transmission and maintenance ...
Fenton, Andy +3 more
core +4 more sources

