Results 51 to 60 of about 9,825 (225)

Structural conservation and functional diversity of the Poxvirus Immune Evasion (PIE) domain superfamily [PDF]

, 2015
Poxviruses encode a broad array of proteins that serve to undermine host immune defenses. Structural analysis of four of these seemingly unrelated proteins revealed the recurrent use of a conserved beta-sandwich fold that has not been observed in any ...
Alcami, Alejo, Altekar, Altschul, Baker, Buatois, Bursill, Byun, Christopher Nelson, Clark, Dabbagh, Daved Fremont, Deane, Finn, Graham, Hendrickson, Hnatiuk, Jabari Elliott, Kelley, Kelley, Lalani, Lateef, Lateef, Lee, Lin, Loparev, McCoy, Megan Epperson, Ng, Pelham, Reading, Rozwarski, Ruiz-Arguello, Seet, Silverman, Smith, Sukrit Singh, Upton, Werden, White, Wilkins   +40 more
core   +3 more sources

Necrotic Ulcerated Lesion in a Young Boy Caused by Cowpox Virus Infection

Case Reports in Dermatology, 2011
The case presented here points towards the fact that skin lesion observed with a cowpox virus is a rare event but should be considered more as the number of cases has increased in the last years. Cowpox virus (CPXV) belongs to the Poxviridae family.
Anne-Laure Favier, Olivier Flusin, Sébastien Lepreux, Hervé Fleury, Christine Labrèze, Aurélie Georges, Jean-Marc Crance, Franck Boralevi   +7 more
doaj   +1 more source

The myth of the medical breakthrough: Smallpox, vaccination, and Jenner reconsidered [PDF]

, 1998
A discussion of the particulars leading to the eradication of smallpox is pertinent to both investigators and the public as the clamor for more “breakthroughs” intensifies.
Gross, Cary P., Sepkowitz, Kent A.
core   +1 more source

Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

Viruses, 2021
Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial ...
Reed F. Johnson, Lauren A. Keith, Timothy K. Cooper, Srikanth Yellayi, Nicole M. Josleyn, Krisztina B. Janosko, James D. Pettitt, David Thomasson, Katie R. Hagen, Robin Gross, John G. Bernbaum, Debbie Douglas, Jeffrey Solomon, Mark Martinez, Kurt Cooper, Marisa St. Claire, Danny R. Ragland, Peter B. Jahrling, Jens H. Kuhn, Andrew E. Arai   +19 more
doaj   +1 more source

Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity

Advanced Science, EarlyView.
This study uncovers a spatiotemporal regulation of STING activity by linear ubiquitination in antiviral immunity. At the early stage of the infection, LUBAC promotes STING linear ubiquitination to drive its trafficking from the ER to the Golgi apparatus for activation.
Yong Zhang, Yesheng Fu, Lihua Qiang, Mengyuan Zhao, Zhe Lu, Zhuo Zhao, Guoping Chen, Zehui Lei, Qiyao Chai, Pupu Ge, Bingxi Li, Jing Wang, Cui Hua Liu, Lingqiang Zhang   +13 more
wiley   +1 more source

Emergence of cowpox: study of the virulence of clinical strains and evaluation of antivirals. [PDF]

PLoS ONE, 2013
The last years, cowpox infections are being increasingly reported through Eurasia. Cowpox viruses (CPXVs) have been reported to have different genotypes and may be subdivided in at least five genetically distinct monophyletic clusters. However, little is
Sophie Duraffour, Barbara Mertens, Hermann Meyer, Joost J van den Oord, Tania Mitera, Patrick Matthys, Robert Snoeck, Graciela Andrei   +7 more
doaj   +1 more source

Comparative pathogenicity of vaccinia virus and mpox virus infections in CAST/EiJ mice: Exploring splenomegaly and transcriptomic profiles

Animal Models and Experimental Medicine, EarlyView.
We successfully constructed CAST/EiJ mice models infected with low‐dose vaccinia virus (VACV‐L), high‐dose VACV (VACV‐H), and mpox virus (MPXV), demonstrating that VACV‐L and MPXV infections induced splenomegaly in mice, and VACV‐H infection caused mortality in mice.
Yongzhi Hou, Jianrong Ma, Baoying Huang, Na Li, Lin Zhu, Ziqing Jia, Jiasen Yang, Jingjing Zhang, Wenjie Tan, Jing Xue   +9 more
wiley   +1 more source

Wise Blood: The Principle of Overcoming in Disease and Immunity (Part 1) [PDF]

, 2020
The immune system is an intelligently made system designed for interaction with microbes even in a perfect world; it is more than a defense. However, in a post-fall world, it is primarily a body’s defense system.
Gillen, Alan L., Huy, Keoprommony
core   +1 more source

Rapid bedside inactivation of Ebola virus for safe nucleic acid tests [PDF]

, 2016
Rapid bedside inactivation of Ebola virus would be a solution for the safety of medical and technical staff, risk containment, sample transport and high-throughput or rapid diagnostic testing during an outbreak.
Bragstad, Karoline, Dudman, Susanne Gjeruldsen, Fomsgaard, Anders, Karlberg, Helen, Kran, Anne Marte Bakken, Lindegren, Gunnel, Mirazimi, Ali, Rosenstierne, Maiken Wors\uf8e, Salata, Cristiano, Stoltz, Malin Lundahl   +9 more
core   +1 more source

Patchy Occurrence of Cowpox Virus in Voles from Germany [PDF]

Vector-Borne and Zoonotic Diseases, 2020
Cowpox virus (CPXV), genus Orthopoxvirus, family Poxviridae, is a zoonotic pathogen in Eurasian wild rodents. High seroprevalences have been reported previously for vole and murine species in Europe. In contrast, viral DNA was only rarely detected, and very few reservoir-derived CPXV isolates exist.
Jörn Gethmann, Rainer G. Ulrich, Martin Beer, Jens Jacob, Stefan Fischer, Annika Franke, Nastasja G Spierling, Donata Hoffmann, Christian Imholt   +8 more
openaire   +2 more sources