Results 61 to 70 of about 9,882 (215)

From the animal house to the field : are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)? [PDF]

, 2017
Inbred mouse strains, living in simple laboratory environments far removed from nature, have been shown to vary consistently in their immune response.
A Gelman, AC Darby, AJ Caton, AJ Gibson, AK Abbas, AK Turner, AK Turner, AL Benjamin, AL Graham, AL Graham, AM Ahmed, B Flahou, BT Seet, CE Johnston, CJ Downs, D Alzhanova, DM Buehler, E Kluen, E Sild, Elena Arriero, EM Eugui, IG Sakala, J Behnke, JA Jackson, JA Jackson, JA Stamps, Janette E. Bradley, JD Hadfield, JE Bradley, Joseph A. Jackson, KD Matson, KJ Bown, Klara M. Wanelik, L Debeffe, Matthew C. Fisher, Mike Begon, NJ Dingemanse, P Kidd, PL Earl, Richard J. Birtles, RS Sellers, S Burthe, S Stearns, S Telfer, SC Patrick, SL Reiner, Steve Paterson, W Liang   +47 more
core   +13 more sources

Skin lesions caused by Orthopoxvirus, cowpox - case report from Poland

Journal of Education, Health and Sport, 2021
Background:Despite the elimination of smallpox, other orthopoxviruses, including cowpox virus, still infect humans. Wild rodents are its natural reservoir.
Konrad Kania, Maria Kalicka, Tomasz Korzec, Przemyslaw Raczkiewicz, Monika Kuc   +4 more
doaj   +1 more source

Biochemical prevention and treatment of viral infections – A new paradigm in medicine for infectious diseases [PDF]

, 2004
For two centuries, vaccination has been the dominating approach to develop prophylaxis against viral infections through immunological prevention. However, vaccines are not always possible to make, are ineffective for many viral infections, and also carry
Fang, Fang, Le Calvez, Hervé, Yu, Mang
core   +3 more sources

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

Viremia in human Cowpox virus infection

Journal of Clinical Virology, 2007
Several poxviruses can infect humans and cause diseases of varying severity. Besides the eradicated Variola virus that induced high mortality rates, numerous further human pathogenic orthopoxviruses are potentially fatal but generally cause less severe infections.
Nitsche, Andreas, Kurth, Andreas, Pauli, Georg   +2 more
openaire   +2 more sources

Immune modulation by virus-encoded secreted chemokine binding proteins [PDF]

, 2015
Chemokines are chemoattractant cytokines that mediate the migration of immune cells to sites of infection which play an important role in innate and adaptive immunity. As an immune evasion strategy, large DNA viruses (herpesviruses and poxviruses) encode
Alcamí, Antonio, Heidarieh, Haleh, Hernáez, Bruno   +2 more
core   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

AIEgen‐Based Proactive Early Warning System and Precise Treatment Strategy for Monkeypox Prevention and Control

Advanced Science, EarlyView.
An intelligent early warning and treatment system for monkeypox, utilizing a sprayable AIEgen‐ liquid dressing (AIE@LD) that responds to lesion pH. Integrated with a smartphone app and cloud platform, it enables real‐time infection detection via fluorescence imaging and triggers on‐demand photodynamic therapy under white light, effectively eradicating ...
Wei Wang, Zining Liu, Mengjun Li, Judun Zheng, Ruilin Zhang, Ke Liu, Xiaoxue Li, Shaoying Wen, Jingze Yu, Meijia Pan, Fengbo Ma, Kun Zhou, Zheng Zhao, Chenguang Shen, Yuhui Liao   +14 more
wiley   +1 more source

Cowpox Virus Transmission from Pet Rats to Humans, France

Emerging Infectious Diseases, 2009
In early 2009, four human cases of cowpox virus cutaneous infection in northern France, resulting from direct contact with infected pet rats (Rattus norvegicus), were studied.
Laetitia Ninove, Yves Domart, Christine Vervel, Chrystel Voinot, Nicolas Salez, Didier Raoult, Hermann Meyer, Isabelle Capek, Christine Zandotti, Remi N. Charrel   +9 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source