Results 1 to 10 of about 2,546 (158)

Cross‐Neutralizing and Broadly Neutralizing Human Antibodies Against Nonenveloped Viruses

European Journal of Immunology, Volume 56, Issue 10, October 2026.
In this review article, Marchand et al. compare cross ‐ and broadly ‐neutralizing human antibodies against non ‐ enveloped viruses from several major families, discussing their structural characteristics, neutralization mechanisms and relevance for the development of antiviral vaccines and therapeutics.
Sarah Marchand, Samy Taouli, Dorian McIlroy   +2 more
wiley   +1 more source

Surveillance, Epidemiology and Impact of EV-A71 Vaccination on Hand, Foot, and Mouth Disease in Nanchang, China, 2010–2019

Frontiers in Microbiology, 2022
After the first national-scale outbreak of Hand, foot, and mouth disease (HFMD) in China, a national surveillance network was established. Here we described the epidemiology and pathogenic profile of HFMD and the impact of EV-A71 vaccination on pathogen ...
Fenglan He, Jia Rui, Zhiqiang Deng, Yanxia Zhang, Ke Qian, Chunhui Zhu, Shanshan Yu, Junling Tu, Wen Xia, Qingxiong Zhu, Shengen Chen, Tianmu Chen, Xianfeng Zhou   +12 more
doaj   +1 more source

Short‐Term Effects of Temperature and Relative Humidity on Hand, Foot, and Mouth Disease in Guiyang, China, From 2022 to 2024: Distributed Lag Nonlinear Model–Based Analysis

iLABMED, Volume 4, Issue 3, Page 158-167, September 2026.
Temperature and relative humidity showed nonlinear and lagged associations with HFMD risk in Guiyang (2022–2024), with the highest cumulative risk under the high‐temperature–high‐relative‐humidity condition. Higher estimated risks were observed among children under 3 years and scattered children, supporting the use of meteorological factors in HFMD ...
Xihong Zhang, Yue Wang, Hua Hu, Jun Yang, Jing Li, Xian Yu   +5 more
wiley   +1 more source

Efficient Assembly of Coxsackievirus A16 Virus‐Like Particles in Insect Cells via VP4‐Deficient P1 Expression

Entomological Research, Volume 56, Issue 8, August 2026.
ABSTRACT Coxsackievirus A16 (CVA16) is a major causative agent of hand, foot, and mouth disease (HFMD), yet efficient virus‐like particle (VLP)–based vaccine development remains challenging due to enteroviral structural complexity and the cytotoxicity of the 3CD protease required for polyprotein processing.
Hyun‐Soo Kim, Hyuk‐Jin Moon, Ra‐Mi Woo, Jae‐Bang Choi, Beom‐Ku Han, Soo Dong Woo   +5 more
wiley   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, Volume 13, Issue 38, 9 July 2026.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Antiviral activity of a crude extract of Thalassia testudinum Banks ex König against the human enteroviruses echovirus 9 and coxsackievirus A16 [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Echovirus 9 (E9) and coxsackievirus A16 (CVA16) are etiological agents of aseptic meningitis and hand, foot, and mouth disease, respectively. Currently, there are no approved antiviral drugs against these viruses.
Liena de R. Ponce Rey, Rafael Frómeta Román, Elizabet Casanova Nodarse, Kethia González García, Luis F. Morier Díaz, Sonia Resik Aguirre, Idania Rodeiro Guerra   +6 more
doaj   +1 more source

Gingival and Periodontal Diseases and Conditions in Children and Adolescents: Consensus Report

Journal of Clinical Periodontology, Volume 53, Issue 7, Page 1068-1099, July 2026.
ABSTRACT Background The objectives of this Focused Workshop were to update the epidemiology, aetiology, risk factors, diagnosis and management of gingival and periodontal diseases and conditions in children and adolescents, and to explore the applicability of the 2018 Classification in children and adolescents.
Iain Chapple, Sotiria Gizani, Mariano Sanz, Dominique Declerck, Phoebus Madianos, Valerie Clerehugh, Monique Danser, Esti Davidovich, Janet Davies, Nikos Donos, Elisabeth Dursun, Elena Figuero, Filippo Graziani, Mervi Gursoy, Soren Jepsen, Clara Joseph, Moritz Kebschull, Norbert Kraemer, Tina Lambrinaki, Rodrigo López, David J. Manton, Joerg Meyle, Ana Molina, Lior Shapira, Cheryl Somani, Georgios Tsilingaridis, Svante Twetman, Nicola West, Biniyam Wondimu, Ferranti Wong, David Herrera   +30 more
wiley   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Age-time-specific transmission of hand-foot-and-mouth disease enterovirus serotypes in Vietnam: A catalytic model with maternal immunity

Epidemics
Hand, foot and mouth disease (HFMD) is highly prevalent in the Asia Pacific region, particularly in Vietnam. To develop effective interventions and efficient vaccination programs, we inferred the age-time-specific transmission patterns of HFMD serotypes ...
Yining Chen, Lam Anh Nguyet, Le Nguyen Thanh Nhan, Phan Tu Qui, Le Nguyen Truc Nhu, Nguyen Thi Thu Hong, Nguyen Thi Han Ny, Nguyen To Anh, Le Kim Thanh, Huynh Thi Phuong, Nguyen Ha Thao Vy, Nguyen Thi Le Thanh, Truong Huu Khanh, Nguyen Thanh Hung, Do Chau Viet, Nguyen Tran Nam, Nguyen Van Vinh Chau, H. Rogier van Doorn, Le Van Tan, Hannah Clapham   +19 more
doaj   +1 more source

Fatal Coxsackievirus A-16 Pneumonitis in Adult

Emerging Infectious Diseases, 2007
Coxsackievirus A-16 (CVA-16) is the agent of hand, foot, and mouth disease in children. We report a case of fatal pneumonitis in an adult due to a CVA-16 strain with a low (78.6%) rate of sequence homology with the reference strain.
François Legay, Nicolas Lévêque, Arnaud Gacouin, Pierre Tattevin, Julien Bouet, Rémi Thomas, Jean-Jacques Chomel   +6 more
doaj   +1 more source