Results 11 to 20 of about 2,546 (158)

Coxsackievirus A16 in Southern Vietnam [PDF]

Frontiers in Microbiology, 2021
Background: Hand, Foot and Mouth Disease (HFMD) is a major public health concern in the Asia-Pacific region. Most recent HFMD outbreaks have been caused by enterovirus A71 (EV-A71), coxsackievirus A16 (CVA16), CVA10, and CVA6.
Le Nguyen Truc Nhu, Le Nguyen Thanh Nhan, Nguyen To Anh, Nguyen Thi Thu Hong, Hoang Minh Tu Van, Hoang Minh Tu Van, Tran Tan Thanh, Vu Thi Ty Hang, Do Duong Kim Han, Nguyen Thi Han Ny, Lam Anh Nguyet, Du Tuan Quy, Phan Tu Qui, Truong Huu Khanh, Nguyen Thanh Hung, Ha Manh Tuan, Nguyen Van Vinh Chau, Guy Thwaites, Guy Thwaites, H. Rogier van Doorn, H. Rogier van Doorn, Le Van Tan   +21 more
doaj   +5 more sources

Genotyping and phylogeographic dynamics of coxsackievirus A16 [PDF]

Heliyon
Coxsackievirus A16 (CV-A16) is one of the major pathogens of Hand, Foot and Mouth disease. Here, we analyzed 287 full-length genome sequences of CV-A16 found worldwide from 1994 to 2019 to see the genomic evolution characteristics.
Xia-Nan Chu, Pir Tariq Shah, Zi-Hui Ma, Yan Wang, Li Xing   +4 more
doaj   +4 more sources

NLRP3-dependent pyroptosis exacerbates coxsackievirus A16 and coxsackievirus A10-induced inflammatory response and viral replication in SH-SY5Y cells [PDF]

Virus Research
Coxsackievirus A16 (CV-A16) and coxsackievirus A10 (CV-A10), more commonly etiological agents of hand, foot and mouth disease (HFMD), are capable of causing severe neurological syndromes with high fatalities, but their neuropathogenesis has rarely been ...
Yajie Hu, Wei Zhao, Yaming Lv, Hui Li, Jiang Li, Mingmei Zhong, Dandan Pu, Fuping Jian, Jie Song, Yunhui Zhang   +9 more
doaj   +4 more sources

A uniform quantitative enzyme-linked immunosorbent assay for Coxsackievirus A16 antigen in vaccine [PDF]

Human Vaccines & Immunotherapeutics, 2021
Coxsackievirus A16 (CV-A16), one of major etiological agents of hand, foot and mouth disease (HFMD), causes outbreaks of the disease in young children all over the world.
Bopei Cui, Fang Cai, Fan Gao, Lianlian Bian, Ruixia Wu, Ruixiao Du, Xing Wu, Pei Liu, Lifang Song, Lisha Cui, Yadi Yuan, Siyuan Liu, Xiangzhong Ye, Tong Cheng, Qunying Mao, Qiang Gao, Zhenglun Liang   +16 more
doaj   +3 more sources

Bioinformatics-based prediction of conformational epitopes for Enterovirus A71 and Coxsackievirus A16 [PDF]

Scientific Reports, 2021
Enterovirus A71 (EV-A71), Coxsackievirus A16 (CV-A16) and CV-A10 are the major causative agents of hand, foot and mouth disease (HFMD). The conformational epitopes play a vital role in monitoring the antigenic evolution, predicting dominant strains and ...
Liping Wang, Miao Zhu, Yulu Fang, Hao Rong, Liuying Gao, Qi Liao, Lina Zhang, Changzheng Dong   +7 more
doaj   +5 more sources

Circulating HFMD-associated coxsackievirus A16 is genetically and phenotypically distinct from the prototype CV-A16. [PDF]

PLoS ONE, 2014
Human enteroviruses (HEV) have been linked to hand, foot, and mouth disease (HFMD) in the Pacific and Southeast Asia for decades. Many cases of HFMD have been attributed to coxsackievirus A16 (CV-A16, CA16), based on only partial viral genome ...
Wei Wei, Haoran Guo, Jingliang Li, Sangsang Ren, Zhenhong Wei, Wanguo Bao, Xiaoming Hu, Ke Zhao, Wenyan Zhang, Yulai Zhou, Fei Sun, Richard Markham, Xiao-Fang Yu   +12 more
doaj   +4 more sources

Genomic epidemiology of coxsackievirus A16 in mainland of China, 2000-18. [PDF]

Virus Evol, 2020
AbstractHand, foot, and mouth disease (HFMD), which is a frequently reported and concerning disease worldwide, is a severe burden on societies globally, especially in the countries of East and Southeast Asia. Coxsackievirus A16 (CV-A16) is one of the most important causes of HFMD and a severe threat to human health, especially in children under 5 years
Han Z, Song Y, Xiao J, Jiang L, Huang W, Wei H, Li J, Zeng H, Yu Q, Li J, Yu D, Zhang Y, Li C, Zhan Z, Shi Y, Xiong Y, Wang X, Ji T, Yang Q, Zhu S, Yan D, Xu W, Zhang Y.   +22 more
europepmc   +4 more sources

Substitution of Coxsackievirus A16 VP1 BC and EF Loop Altered the Protective Immune Responses in Chimera Enterovirus A71 [PDF]

Vaccines, 2023
Hand, foot and mouth disease (HFMD) is a childhood disease caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16). Capsid loops are important epitopes for EV-A71 and CV-A16.
Xiu Hui Tan, Wei Lim Chong, Vannajan Sanghiran Lee, Syahril Abdullah, Kartini Jasni, Saiful Qushairi Suarni, David Perera, I-Ching Sam, Yoke Fun Chan   +8 more
doaj   +2 more sources

Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. [PDF]

Cell Host Microbe, 2020
Hand, foot, and mouth disease is a common childhood illness primarily caused by coxsackievirus A16 (CVA16), for which there are no current vaccines or treatments. We identify three CVA16-specific neutralizing monoclonal antibodies (nAbs) with therapeutic potential: 18A7, 14B10, and NA9D7.
He M, Xu L, Zheng Q, Zhu R, Yin Z, Zha Z, Lin Y, Yang L, Huang Y, Ye X, Li S, Hou W, Wu Y, Han J, Liu D, Li Z, Chen Z, Yu H, Que Y, Wang Y, Yan X, Zhang J, Gu Y, Zhou ZH, Cheng T, Li S, Xia N.   +26 more
europepmc   +7 more sources

Pathologic and immunologic characteristics of coxsackievirus A16 infection in rhesus macaques

Virology, 2017
Coxsackievirus A16 (CV-A16) causes human hand, foot and mouth disease, but its pathogenesis is unclear. In rhesus macaques, CV-A16 infection causes characteristic vesicles in the oral mucosa and limbs as well as viremia and positive viral loads in the tissues, suggesting that these animals reflect the pathologic process of the infection. An immunologic
Longding Liu, Lei Guo, Erxia Yang
exaly   +3 more sources