Results 111 to 120 of about 164,159 (291)

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Pulmonary mucosal immunity mediated through CpG provides adequate protection against pulmonary Mycobacterium tuberculosis infection in the mouse model. A role for type I interferon

, 2020
Amber Troy, Sandra Cecilia Esparza‐González, Alicia Bartek, Elizabeth Creissen, Linda Izzo, Angelo Izzo   +5 more
openalex   +2 more sources

A Prussian Blue Nanozyme‐Adjuvanted Vaccine Presenting Phosphocholine Antigens for Induction of Immunotolerance in Inflammatory Bowel Disease

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is a complex disorder characterized by chronic intestinal inflammation and impaired barrier function, for which effective long‐term therapies remain elusive. To address this challenge, we developed a novel nano‐vaccine that combines Prussian blue nanozymes (PBNZs) adjuvants with a ferritin carrier loaded with ...
Jingyi Sheng, Yubo Huang, Xinyue Li, Yin Liu, Yuehuang Wu, Yuxin Zhang, Ning Gu   +6 more
wiley   +1 more source

Hydrophobically Modified Chitosan‐Based Polymers for Enhanced Oil Recovery

CleanMat
The upstream petroleum industry significantly contributes to environmental pollution through the use of fossil‐derived chemicals. This study explores the potential of green alternatives by synthesizing and evaluating chitosan‐based polymers for enhanced ...
Alexandra Scerbacova, Ibtisam I. Bin Sharfan, Mahmoud A. Abdulhamid   +2 more
doaj   +1 more source

Role of Interleukin-6 in the Antigen-Specific Mucosal Immunoglobulin A Responses Induced by CpG Oligodeoxynucleotide-Loaded Cationic Liposomes [PDF]

, 2022
Rui Tada, Emi Honjo, Shoko Muto, Noriko Takayama, Hiroshi Kiyono, Jun Kunisawa, Yoichi Negishi   +6 more
openalex   +1 more source

Economic Viability of Photovoltaic Systems Providing Frequency Containment Reserve

Advanced Energy and Sustainability Research, EarlyView.
This article investigates the feasibility of photovoltaic (PV) systems providing frequency containment reserve (FCR) in the Netherlands. The economic analysis demonstrates that a PV plant can profitably participate in FCR without battery storage by maintaining an active power reserve.
Emil Petkovski, Mari S. Bogen, Theo Bosma, Marcel Eijgelaar   +3 more
wiley   +1 more source

CpG-ODN Signaling via Dendritic Cells-Expressing MyD88, but Not IL-10, Inhibits Allergic Sensitization [PDF]

, 2021
Ricardo Wesley Alberca, E. Gomes, Momtchilo Russo   +2 more
openalex   +1 more source

AI‐Enhanced Surface‐Enhanced Raman Scattering for Accurate and Sensitive Biomedical Sensing

Advanced Intelligent Discovery, EarlyView.
AI‐SERS advances spectral interpretation with greater precision and speed, enhancing molecular detection, biomedical analysis, and imaging. This review explores its essential contributions to biofluid analysis, disease identification, therapeutic agent evaluation, and high‐resolution biomedical imaging, aiding diagnostic decision‐making.
Seungki Lee, Rowoon Park, Ho Sang Jung
wiley   +1 more source

Suppressive CpG [PDF]

The Journal of Experimental Medicine, 2005
openaire   +1 more source

CpG island methylator phenotype and its association with malignancy in sporadic duodenal adenomas [PDF]

, 2014
Lifeng Sun, Angela A. Guzzetta, Tao Fu, Jinming Chen, Jana Jeschke, Ruby Kwak, Rajita Vatapalli, Stephen B. Baylin, Christine A. Iacobuzio–Donahue, Christopher L. Wolfgang, Nita Ahuja   +10 more
openalex   +1 more source