Results 111 to 120 of about 152,781 (323)

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3

Advanced Science, EarlyView.
MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi, Yu Tian, Yu‐fan Wang, Yi‐ran Zhang, Ying Yin, Qing Tian, Lei Li, Bing‐xin Ma, Ximiao He, Li‐quan Zhou   +9 more
wiley   +1 more source

Molecular and cellular paradigms of multidrug resistance in cancer

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including chemotherapies, radiotherapy, surgery and targeted therapies are being employed for the treatment of cancer.
Foram U. Vaidya, Abu Sufiyan Chhipa, Vinita Mishra, Vishal Kumar Gupta, Shiv Govind Rawat, Ajay Kumar, Chandramani Pathak   +6 more
wiley   +1 more source

Paternal Obesity‐Induced H3K27me3 Elevation Leads to MANF‐Mediated Transgenerational Metabolic Dysfunction in Female Offspring

Advanced Science, EarlyView.
Paternal lifestyle and environmental exposures play a critical role in the offspring's health. The present study established a paternal obesity model and demonstrated that elevated H3K27me3 levels in sperm persist through the 8‐cell embryo stage. This epigenetic modification triggers transgenerational decrease of MANF, inducing ER stress and activating
Yajun Shi, Weisheng Li, Xi Yu, Yan Zhao, Dan Zhu, Yueyang Song, Zejun Zhao, Yannan Gu, Bin Wei, Lingjun Li, Dongyi Yu, Pengjie Zhang, Qinqin Gao, Miao Sun   +13 more
wiley   +1 more source

Correction to: Probabilistic estimation of hydraulic fracture half-lengths: validating the Gaussian pressure-transient method with the traditional rate transient analysis-method (Wolfcamp case study)

Journal of Petroleum Exploration and Production Technology, 2023
Dandi Alvayed, Mohammed Sofian Ali Khalid, Moaz Dafaalla, Ahmed Ali, Ahmed Farid Ibrahim, Ruud Weijermars   +5 more
doaj   +1 more source

AI Driven Knowledge Extraction from Clinical Practice Guidelines: Turning Research into Practice [PDF]

arXiv, 2020
Background and Objectives: Clinical Practice Guidelines (CPGs) represent the foremost methodology for sharing state-of-the-art research findings in the healthcare domain with medical practitioners to limit practice variations, reduce clinical cost, improve the quality of care, and provide evidence based treatment. However, extracting relevant knowledge
arxiv  

Bioinspired Mechanisms and Actuation of Soft Robotic Crawlers

Advanced Science, EarlyView.
Researchers have been developing soft materials and robotic crawlers inspired by soft‐bodied animals to mimic effective crawling in complex environments. This review explores the state‐of‐the‐art in soft crawlers, highlighting the interaction between materials, crawling mechanisms, actuation, and applications. The review concludes by providing insights
Min Pan, Miaomiao Liu, Jiayi Lei, Yunyi Wang, Changhong Linghu, Chris Bowen, K. Jimmy Hsia   +6 more
wiley   +1 more source

On the self-CPG curves and the Björling problem [PDF]

arXiv, 2010
Schwartz's solution to the Bj\"orling problem leads to an equivalence class of spatial strips S(t)=(c(t),n(t)) which produce equivalent minimal surfaces. For the particular case when the generating strip S(t) belongs to some plane E and c(t) is symmetric with respect to some straight line in E, the symmetries of the minimal surface permit us to ...
arxiv  

Enhancing Prime Editing Efficiency Through Modulation of Methylation on the Newly Synthesized DNA Strand and Prolonged Expression

Advanced Science, EarlyView.
Prime editors (PEs) enhance gene editing precision but face repair mechanism limitations. DNA methylation (CpG sites) and de novo methyltransferases (DNMT3A/DNMT3B) boost PE efficiency. We developed an episomal PE system (epiPE) using EBNA1/oriP to sustain expression and methylation.
Xiaosong Han, Xianghua Xu, Youcai Xiong, Guangxing Zhao, Ruigao He, Yinyu Su, Sheng Li, Changzhi Zhao, Xiaoning Xi, Yunxia Zhao, Xuewen Xu, Shengsong Xie, Heng Wang, Xinyun Li, Shuhong Zhao, Jinxue Ruan   +15 more
wiley   +1 more source

Association between heart failure quality of care and mortality: a population‐based cohort study using nationwide registries

European Journal of Heart Failure, Volume 24, Issue 11, Page 2066-2077, November 2022., 2022
Hospital performance and outcomes according to the 2021 European Society of Cardiology (ESC) quality indicators for heart failure (HF). ACEI, angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor–neprilysin inhibitor; CRT, cardiac resynchronization therapy; ECG, electrocardiogram; HFrEF, heart failure ...
Gorav Batra, Suleman Aktaa, Lina Benson, Ulf Dahlström, Camilla Hage, Gianluigi Savarese, Peter Vasko, Chris P. Gale, Lars H. Lund   +8 more
wiley   +1 more source