Results 11 to 20 of about 155,959 (265)
Genome Research, 1997 We describe an analysis of the CpG islands (CGIs) of the pig. We have used both database survey and a porcine genomic library that is enriched for CGIs. Approximately half of 41 pig genomic database sequences had CGIs with an average G + C content of 65.3%, an average CpG observed/expected frequency of 0.85, and an average size of 978 bp.
McQueen, H A +4 more
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Preservation of methylated CpG dinucleotides in human CpG islands [PDF]
Biology Direct, 2016 CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic regions called CpG islands (CGIs) is noticeably higher.
Panchin, Alexander Y. +2 more
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CpG dinucleotides and the mutation rate of non-CpG DNA [PDF]
Genome Research, 2008 The neutral mutation rate is equal to the base substitution rate when the latter is not affected by natural selection. Differences between these rates may reveal that factors such as natural selection, linkage, or a mutator locus are affecting a given sequence.
Walser, J., Ponger, L., Furano, A. V.
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Current Protocols in Nucleic Acid Chemistry, 2003 AbstractThe vertebrate immune system can recognize specific pathogen‐associated molecular patterns in invading microorganisms, including the unmethylated CpG dinucleotide. This unit discusses the receptors that recognize CpG motifs and important aspects of the sequence context of CpG motifs to the end of understanding and designing CpG DNA for ...
Kandimalla, Ekambar R., Agrawal, Sudhir
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The mutational spectrum of non-CpG DNA varies with CpG content [PDF]
Genome Research, 2010 The accumulation of base substitutions (mutations) not subject to natural selection is the neutral mutation rate. Because this rate reflects the in vivo processes involved in maintaining the integrity of genetic information, the factors that affect the neutral mutation rate are of considerable interest.
Walser, Jean-Claude, Furano, Anthony V.
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Factors to preserve CpG-rich sequences in methylated CpG islands [PDF]
BMC Genomics, 2015 Mammalian CpG islands (CGIs) normally escape DNA methylation in all adult tissues and developmental stages. However, in our previous study we unexpectedly identified many methylated CGIs in human peripheral blood leukocytes. Methylated CpG dinucleotides convert to TpG dinucleotides through deaminization of their cytosine bases more frequently than ...
Miyahara, Hiroki +3 more
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CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI [PDF]
Proceedings of the National Academy of Sciences, 2012 Cytosine methylation promotes deamination. In eukaryotes, CpG methylation is thought to account for CpG underrepresentation. Whether scarcity of CpGs in prokaryotic genomes is diagnostic for methylation is not clear. Here, we report that Mycoplasms tend to be CpG depleted and to harbor a family of constitutively expressed or phase ...
Marek, Wojciechowski +2 more
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Prognostic significance of MGMT promoter methylation in diffuse glioma patients
Biotechnology & Biotechnological Equipment, 2019 Current treatment options for diffuse glioma patients include maximum safe resection followed by a combination of radiation therapy and chemotherapy with alkylating agents.
Nikola Jovanović +10 more
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OncoImmunology, 2020 Whereas TLR9 agonists are recognized as powerful stimulators of antitumor immunity, GM-CSF has had mixed reviews. In previously reported randomized trials we assessed the effects of local immune modulation in early-stage melanoma with CpG-B alone or with
Bas D. Koster +9 more
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Pathogenicity and virulence of hepatitis A virus
Virulence, 2021 Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and increases the severity with age. Although in most patients the infection resolves completely, in a few of them it may follow a prolonged or relapsed course or ...
Rosa M Pintó +6 more
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