Results 21 to 30 of about 196,785 (313)

Efficacy of CpG-ODN Administration Routes on Humoral Responses against Newcastle disease in Broilers [PDF]

Archives of Razi Institute, 2019
Un-methylated cytosine-phosphate-guanosine oligodeoxynucleotides (CpG-ODN) has been considered as a powerful vaccine adjuvant and recognition of CpG-ODN by chicken leukocytes promotes their ability to fight against infections.
A. Talebi, S. Arky-rezai
doaj   +1 more source

A Toll for lupus [PDF]

, 2005
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders, Hans-Joachim, H-J Anders
core   +1 more source

In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanoma

OncoImmunology, 2020
Whereas TLR9 agonists are recognized as powerful stimulators of antitumor immunity, GM-CSF has had mixed reviews. In previously reported randomized trials we assessed the effects of local immune modulation in early-stage melanoma with CpG-B alone or with
Bas D. Koster, Tamarah D. de Jong, Mari F. C. M. van den Hout, Berbel J. R. Sluijter, Ronald J. C. L. M. Vuylsteke, Barbara G. Molenkamp, Saskia Vosslamber, M. Petrousjka van den Tol, Alfons J. M. van den Eertwegh, Tanja D. de Gruijl   +9 more
doaj   +1 more source

Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns [PDF]

, 2012
: BACKGROUND: Aberrant CpG island promoter DNA hypermethylation is frequently observed in cancer and is believed to contribute to tumor progression by silencing the expression of tumor suppressor genes.
Sproul, Duncan, J Michael Dixon, Nestor, Colm E,, Ramsahoye, Bernard H, Nestor, Colm E, Sims, Andrew H, Harrison, David J, Meehan, Richard R,, Sims, Andrew H,, Dixon, J Michael,, David J Harrison, Ramsahoye, Bernard H,, Kitchen, Robert R, Sproul, Duncan,, Meehan, Richard R, Richard R Meehan, Dixon, J Michael, Andrew H Sims, Bernard H Ramsahoye, Robert R Kitchen, Duncan Sproul, Harrison, David J,, Colm E Nestor, Kitchen, Robert R,   +23 more
core   +1 more source

CpG-Conjugated Silver Nanoparticles as a Multifunctional Nanomedicine to Promote Macrophage Efferocytosis and Repolarization for Atherosclerosis Therapy

, 2023
Atherosclerosis (AS) is a major contributor to cardiovascular diseases, necessitating the development of novel therapeutic strategies to alleviate plaque burden.
Wenhu Zhou (1624450), Guoping Yang (3193257), Cui Tang (3092805), Hui Wang (30400), Hanyong Zhang (17320089), Jianming Hu (204384), Lina Guo (706104), Chan Zou (1987090)   +7 more
core   +1 more source

Prognostic significance of MGMT promoter methylation in diffuse glioma patients

Biotechnology & Biotechnological Equipment, 2019
Current treatment options for diffuse glioma patients include maximum safe resection followed by a combination of radiation therapy and chemotherapy with alkylating agents.
Nikola Jovanović, Tatjana Mitrović, Vladimir J. Cvetković, Svetlana Tošić, Jelena Vitorović, Slaviša Stamenković, Vesna Nikolov, Aleksandar Kostić, Nataša Vidović, Tatjana Jevtović-Stoimenov, Dušica Pavlović   +10 more
doaj   +1 more source

Is inhaled immunotherapy more effective than environmental management when treating equine asthma?

Veterinary Evidence, 2021
PICO question In horses with severe equine asthma syndrome, is inhaled immunotherapy compared to environmental reduction of allergen exposure more effective in disease modification?
Amy Leather, Sarah Smith
doaj   +1 more source

Synergy effects of Polyinosinic-polycytidylic acid, CpG oligodeoxynucleotide, and cationic peptides to adjuvant HPV E7 epitope vaccine through preventive and therapeutic immunization in a TC-1 grafted mouse model

Human Vaccines & Immunotherapeutics, 2018
Cross-talk by pattern recognition receptors may facilitate the maturation of dendritic cells and fine tune the immune response. Thus, the inclusion of ligands agonistic to multiple receptors in a vaccine formula may be an effective strategy to elicit ...
Cunbao Liu, Xiaojie Chu, Pengyan Sun, Xuejun Feng, Weiwei Huang, Hongxian Liu, Yanbing Ma   +6 more
doaj   +1 more source

Rhythm Pattern of Sole through Electrification of the Human Body When Walking

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2008
The rhythm of automatic cyclic movements such as walking is known to be generated by a rhythm generator called CPG in the spinal cord. The measurement of rhythm characteristics in walking is considered to be important for analyzing human bipedal walking ...
Kiyoaki TAKIGUCHI, Takayuki WADA, Shigeki TOHYAMA   +2 more
doaj   +1 more source

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication [PDF]

, 2014
Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and UpA ...
Atkinson, N J, Simmonds, Peter, Atkinson, Nicky J., Evans, David J., Witteveldt, Jeroen, Evans, D. J.   +5 more
core   +1 more source