Results 41 to 50 of about 318,338 (358)

DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. [PDF]

, 2017
INTRODUCTION:The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways.
Chidambaran, Vidya, Ding, Lili, Geisler, Kristie, Ji, Hong, Martin, Lisa J, Sadhasivam, Senthilkumar, Stubbeman, Bobbie L, Weirauch, Matthew T, Zhang, Xue   +8 more
core   +1 more source

Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants

Human Vaccines & Immunotherapeutics, 2022
Low-cost, refrigerator-stable COVID-19 vaccines will facilitate global access and improve vaccine coverage in low- and middle-income countries. To this end, subunit-based approaches targeting the receptor-binding domain (RBD) of SARS-CoV-2 Spike protein ...
Sakshi Bajoria, Kawaljit Kaur, Ozan S. Kumru, Greta Van Slyke, Jennifer Doering, Hayley Novak, Sergio A. Rodriguez Aponte, Neil C. Dalvie, Christopher A. Naranjo, Ryan S. Johnston, Judith Maxwell Silverman, Harry Kleanthous, J. Christopher Love, Nicholas J. Mantis, Sangeeta B. Joshi, David B. Volkin   +15 more
doaj   +1 more source

Organic Matter Burial in Deep-Sea Fans: A Depositional Process-Based Perspective

Journal of Marine Science and Engineering, 2022
Organic matter burial in the deep-sea fan sediments is an important component of the long-term carbon cycle. Although there is increasing recognition of the importance of organic matter in deep-sea sediments, a major focus has been on mudstones, commonly
Arif Hussain, Khalid Al-Ramadan
doaj   +1 more source

Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function

Epigenetics, 2022
DNA methylation (DNAm) in mammals is mostly examined within the context of CpG dinucleotides. Non-CpG DNAm is also widespread across the human genome, but the functional relevance, tissue-specific disposition, and inter-individual variability has not ...
Philip Titcombe, Robert Murray, Matthew Hewitt, Elie Antoun, Cyrus Cooper, Hazel M Inskip, Joanna D Holbrook, Keith M Godfrey, Karen Lillycrop, Mark Hanson, Sheila J Barton   +10 more
doaj   +1 more source

Multiple types of control by identified interneurons in a sensory-activated rhythmic motor pattern. [PDF]

, 2001
Modulatory interneurons that can drive central pattern generators (CPGs) are considered as good candidates for decision-making roles in rhythmic behaviors.
Benjamin, Paul R, Kemenes, György, Staras, Kevin   +2 more
core   +2 more sources

Detection of suspicious interactions of spiking covariates in methylation data [PDF]

, 2020
BACKGROUND: In methylation analyses like epigenome-wide association studies, a high amount of biomarkers is tested for an association between the measured continuous outcome and different covariates.
Kruppa, Jochen, Richter, Gesa, Schaefer, Arne S., Sieg, Miriam   +3 more
core   +1 more source

A probabilistic appraisal of Project Greensand: Economic viability of offshore geological CO₂ storage under uncertainty

Energy Reports
This study presents an economic appraisal of Project Greensand in the Danish North Sea, a leading offshore CO₂ storage initiative that conducted injection pilot tests in 2023 and is slated for further development.
Ruud Weijermars, Ose Budiman, Khaled Al-Raeeini, Tengku Astsauri   +3 more
doaj   +1 more source

CpG-Based Nanovaccines for Cancer Immunotherapy

International Journal of Nanomedicine, 2021
Wenqiang Chen,1 Mingxia Jiang,1 Wenjing Yu,1 Zhiwei Xu,1 Xinyue Liu,1 Qingmiao Jia,1 Xiuwen Guan,1– 3 Weifen Zhang1– 3 1College of Pharmacy, Weifang Medical University, Weifang, 261053, People’s Republic of China; 2Collaborative Innovation Center for ...
Chen W, Jiang M, Yu W, Xu Z, Liu X, Jia Q, Guan X, Zhang W   +7 more
doaj  

A trimeric spike-based COVID-19 vaccine candidate induces broad neutralization against SARS-CoV-2 variants

Human Vaccines & Immunotherapeutics, 2023
COVID-19 pandemic caused by SARS-CoV-2 infection has an impact on global public health and social economy. The emerging immune escape of SARS-CoV-2 variants pose great challenges to the development of vaccines based on original strains.
Feixia Gao, Mei Zheng, Jiangfeng Fan, Yahong Ding, Xueying Liu, Min Zhang, Xin Zhang, Jinrong Dong, Xu Zhou, Jian Luo, Xiuling Li   +10 more
doaj   +1 more source

Identification of CpG islands using a bank of IIR lowpass filters [PDF]

, 2004
It has been known that biological sequences such as the DNA sequence display different kinds of patterns depending on their biological functions. This statistical difference can be exploited for identifying the region of interest, such as the protein ...
Vaidyanathan, P. P., Yoon, Byung-Jun
core