Results 41 to 50 of about 196,785 (313)
Blood, 2021 In this issue of Blood, Konkle et al report that 7 of 8 participants in a phase 1/2 trial of adeno-associated virus (AAV) vector (BAX335) for factor IX (FIX)-Padua gene transfer in patients with hemophilia B did not maintain expression despite steroid intervention, which the authors hypothesize is a result of the innate immune stimulatory effect of ...
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
, 2002 During bacterial infections, the balance between resolution of infection and development of sepsis is dependent upon the macrophage response to bacterial products.
Sweet, Matthew J +15 more
core +1 more source
Human Vaccines & Immunotherapeutics, 2023 COVID-19 pandemic caused by SARS-CoV-2 infection has an impact on global public health and social economy. The emerging immune escape of SARS-CoV-2 variants pose great challenges to the development of vaccines based on original strains.
Feixia Gao +10 more
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MethodsX, 2022 Clastic reservoir core is routinely characterized using conventional, destructive spot sampling techniques. Whilst spot sampling provides useful textural and compositional information, the samples are typically widely spaced (∼ 25 cm), and hence ...
Arif Hussain, Khalid Al-Ramadan
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CoRR, 2018 We show that for any $k \geq 0$, there exists a planar graph which is $B_{k+1}$-CPG but not $B_k$-CPG. As a consequence, we obtain that $B_k$-CPG is a strict subclass of $B_{k+1}$-CPG.
Nicolas Champseix +2 more
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Workflow for Probabilistic Resource Estimation: Jafurah Basin Case Study (Saudi Arabia)
Energies, 2021 This study provides a workflow and preliminary estimations of the estimated ultimate recovery (EUR) volumes for natural gas and condensate liquids in the Tuwaiq Mountain Formation, the principal target in the Jafurah Field development project in Saudi ...
Ruud Weijermars +2 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
CpG-specific antiviral activity of HA and GFP tagged ZAP isoforms.
, 2021 Infectious virus yield from HEK293T ZAP KO cells co-transfected with wild type (WT; black) HIV-1 and CpG-enriched mutant (CpG-high; red) viruses and increasing doses of pcDNA ZAP with N-terminal hemagglutinin tag (HA) or monomeric enhanced green ...
María José Lista (11604310) +4 more
core +1 more source