Results 31 to 40 of about 155,959 (265)

A trimeric spike-based COVID-19 vaccine candidate induces broad neutralization against SARS-CoV-2 variants

open access: yesHuman Vaccines & Immunotherapeutics, 2023
COVID-19 pandemic caused by SARS-CoV-2 infection has an impact on global public health and social economy. The emerging immune escape of SARS-CoV-2 variants pose great challenges to the development of vaccines based on original strains.
Feixia Gao   +10 more
doaj   +1 more source

A core-based XRF scanning workflow for continuous measurement of mineralogical variations in clastic reservoirs

open access: yesMethodsX, 2022
Clastic reservoir core is routinely characterized using conventional, destructive spot sampling techniques. Whilst spot sampling provides useful textural and compositional information, the samples are typically widely spaced (∼ 25 cm), and hence ...
Arif Hussain, Khalid Al-Ramadan
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan   +3 more
wiley   +1 more source

Workflow for Probabilistic Resource Estimation: Jafurah Basin Case Study (Saudi Arabia)

open access: yesEnergies, 2021
This study provides a workflow and preliminary estimations of the estimated ultimate recovery (EUR) volumes for natural gas and condensate liquids in the Tuwaiq Mountain Formation, the principal target in the Jafurah Field development project in Saudi ...
Ruud Weijermars   +2 more
doaj   +1 more source

Planar CPG graphs

open access: yesCoRR, 2018
We show that for any $k \geq 0$, there exists a planar graph which is $B_{k+1}$-CPG but not $B_k$-CPG. As a consequence, we obtain that $B_k$-CPG is a strict subclass of $B_{k+1}$-CPG.
Nicolas Champseix   +2 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

No CpGs for AAVs? [PDF]

open access: yesBlood, 2021
In this issue of Blood, Konkle et al report that 7 of 8 participants in a phase 1/2 trial of adeno-associated virus (AAV) vector (BAX335) for factor IX (FIX)-Padua gene transfer in patients with hemophilia B did not maintain expression despite steroid intervention, which the authors hypothesize is a result of the innate immune stimulatory effect of ...
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Leveraging petrophysical and geological constraints for AI-driven predictions of total organic carbon (TOC) and hardness in unconventional reservoir prospects

open access: yesGeomechanics and Geophysics for Geo-Energy and Geo-Resources
Key parameters for evaluating shale reservoirs include total organic carbon (TOC), thermal maturity, and hardness, the latter influencing fracture development and being crucial for managing ultralow permeability reservoirs.
Nandito Davy   +6 more
doaj   +1 more source

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