Results 31 to 40 of about 196,785 (313)

Tumor Microenvironment Multiple Responsive Nanoparticles for Targeted Delivery of Doxorubicin and CpG Against Triple-Negative Breast Cancer

International Journal of Nanomedicine, 2022
Fenfen Gu,1,* Chuling Hu,2,* Wei Cao,3,* Chao Li,1 Qingming Xia,4 Yuan Gao,4 Yan Liu,1 Shen Gao1,4 1Department of Clinical Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of
Gu F, Hu C, Cao W, Li C, Xia Q, Gao Y, Liu Y, Gao S   +7 more
doaj  

Pathogenicity and virulence of hepatitis A virus

Virulence, 2021
Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and increases the severity with age. Although in most patients the infection resolves completely, in a few of them it may follow a prolonged or relapsed course or ...
Rosa M Pintó, Francisco-Javier Pérez-Rodríguez, Maria-Isabel Costafreda, Gemma Chavarria-Miró, Susana Guix, Enric Ribes, Albert Bosch   +6 more
doaj   +1 more source

Enxerto autógeno de crista ilíaca na reconstrução do processo alveolar em portadores de fissura labiopalatina: estudo de 30 casos

Revista do Colégio Brasileiro de Cirurgiões
A reconstrução do processo alveolar em pacientes portadores de fissuras labiopalatais (FLP) é fundamental para erupção de dentes permanentes e para o restabelecimento estético através de implantes osteointegrados.
João Luiz Carlini, André Luís Zétola, Ricardo Pires de Souza, Odilon Victor Porto Denardin, Abrão Rapoport   +4 more
doaj   +1 more source

TLR9-mediated activation of dendritic cells by CD32 targeting for the generation of highly immunostimulatory vaccines

Human Vaccines & Immunotherapeutics, 2019
The rational for designing dendritic cell (DC)-targeted immunotherapies is their central role in orchestrating immunity. Most studies addressing antigen-targeting to DCs for eliciting T cell responses have employed ex-vivo matured DCs derived from ...
J. A. Sepulveda-Toepfer, Johannes Pichler, Kathrin Fink, Milica Sevo, Sonja Wildburger, Liesbeth Christiene Mudde-Boer, Christopher Taus, Geert Cornelius Mudde   +7 more
doaj   +1 more source

CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo

, 2007
Background Bacterial DNA containing motifs of unmethylated CpG dinucleotides (CpG-ODN) initiate an innate immune response mediated by the pattern recognition receptor Toll-like receptor 9 (TLR9).
Schwederski Markus, Koch, Alexander, Schwederski, Markus, Ehrentraut Heidi, Baumgarten, Georg, Ehrentraut, Heidi, Hoeft, Andreas, Velten, Markus, Knüfermann, Pascal, Zacharowski Kai, Hoeft Andreas, Mersmann Jan, Knuefermann Pascal, Meyer Rainer, Grohé Christian, Baumgarten Georg, Zacharowski, Kai, Koch Alexander, Meyer, Rainer, Grohé, Christian, Velten Markus, Mersmann, Jan   +21 more
core   +1 more source

Organic Matter Burial in Deep-Sea Fans: A Depositional Process-Based Perspective

Journal of Marine Science and Engineering, 2022
Organic matter burial in the deep-sea fan sediments is an important component of the long-term carbon cycle. Although there is increasing recognition of the importance of organic matter in deep-sea sediments, a major focus has been on mudstones, commonly
Arif Hussain, Khalid Al-Ramadan
doaj   +1 more source

Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants

Human Vaccines & Immunotherapeutics, 2022
Low-cost, refrigerator-stable COVID-19 vaccines will facilitate global access and improve vaccine coverage in low- and middle-income countries. To this end, subunit-based approaches targeting the receptor-binding domain (RBD) of SARS-CoV-2 Spike protein ...
Sakshi Bajoria, Kawaljit Kaur, Ozan S. Kumru, Greta Van Slyke, Jennifer Doering, Hayley Novak, Sergio A. Rodriguez Aponte, Neil C. Dalvie, Christopher A. Naranjo, Ryan S. Johnston, Judith Maxwell Silverman, Harry Kleanthous, J. Christopher Love, Nicholas J. Mantis, Sangeeta B. Joshi, David B. Volkin   +15 more
doaj   +1 more source

A probabilistic appraisal of Project Greensand: Economic viability of offshore geological CO₂ storage under uncertainty

Energy Reports
This study presents an economic appraisal of Project Greensand in the Danish North Sea, a leading offshore CO₂ storage initiative that conducted injection pilot tests in 2023 and is slated for further development.
Ruud Weijermars, Ose Budiman, Khaled Al-Raeeini, Tengku Astsauri   +3 more
doaj   +1 more source

CpG-Based Nanovaccines for Cancer Immunotherapy

International Journal of Nanomedicine, 2021
Wenqiang Chen,1 Mingxia Jiang,1 Wenjing Yu,1 Zhiwei Xu,1 Xinyue Liu,1 Qingmiao Jia,1 Xiuwen Guan,1– 3 Weifen Zhang1– 3 1College of Pharmacy, Weifang Medical University, Weifang, 261053, People’s Republic of China; 2Collaborative Innovation Center for ...
Chen W, Jiang M, Yu W, Xu Z, Liu X, Jia Q, Guan X, Zhang W   +7 more
doaj  

Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function

Epigenetics, 2022
DNA methylation (DNAm) in mammals is mostly examined within the context of CpG dinucleotides. Non-CpG DNAm is also widespread across the human genome, but the functional relevance, tissue-specific disposition, and inter-individual variability has not ...
Philip Titcombe, Robert Murray, Matthew Hewitt, Elie Antoun, Cyrus Cooper, Hazel M Inskip, Joanna D Holbrook, Keith M Godfrey, Karen Lillycrop, Mark Hanson, Sheila J Barton   +10 more
doaj   +1 more source