Results 81 to 90 of about 164,159 (291)

CpG‐ODN‐mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFκB inhibitory protein IκBβ to drive IL1α and IL1β expression [PDF]

, 2020
Robyn De Dios, Leanna Nguyen, Sankar Ghosh, Sarah McKenna, Clyde J. Wright   +4 more
openalex   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Does hypermethylation of CpG island in the promoter region of the E‐cadherin gene increase the risk of lung cancer? A meta‐analysis [PDF]

, 2018
Zhenfeng Sun, Gongzhe Liu, Ning Xu
openalex   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

A Ferritin-Based Eg95 Nanoparticle Vaccine Adjuvanted with pCpG Eliciting Robust Immune Responses Against Cystic Echinococcosis in Mice Model

International Journal of Nanomedicine
Xintao Gao,1,* Xizhou Zhu,2,* Xingjian Liu,1 Chenghao Zhou,1 Yuting Shang,1 Tong Wu,1 Hong Jia,3 Zhifang Zhang,1 Yinü Li,1 Ting Xin3 1National Key Laboratory of Agricultural Microbiology, Biotechnology Research Institute, Chinese Academy of ...
Gao X, Zhu X, Liu X, Zhou C, Shang Y, Wu T, Jia H, Zhang Z, Li Y, Xin T   +9 more
doaj  

Cosmid walking and chromosome jumping in the region of PKD1 reveal a locus duplication and three CpG islands [PDF]

, 1990
Gerald A.J. Gillespie, Gregory G. Germino, Stefan Somio, Debra Weinstat‐Saslow, Martijn H. Breuning, Stephen T. Reeders   +5 more
openalex   +1 more source

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

Evaluating poro-elastic production drive mechanisms: Quantifying the potential contribution to well-rates and risk of core handling damage inflating pore-volume compressibility measurements

Energy Geoscience
By analyzing core data from an offshore Gulf of Mexico reservoir and developing analytical solutions, it can be demonstrated that laboratory measurements on pore-volume compressibility include artifacts, leading to a misinterpretation of porosity and ...
Ruud Weijermars
doaj   +1 more source

Spatiotemporally Controlled Tumor Photodynamic/Immunotherapy Therapy Based on Upconversion Hybrid Nanosystem

Advanced Science, EarlyView.
PURH is constructed by a five‐layer upconversion nanoparticle (UCNP) surface coated with mesoporous silica, which encapsulates rose bengal (RB) within the mesoporous channels. Additionally, CpG oligonucleotides (CpG ODN) is linked to the surface, followed by the surface functionalization of hyaluronic acid (HA). This spatiotemporally controllable smart
Fang Wang, Wenfei Xu, Yuechen Liu, Shuxuan Zhu, Wenjing Liu, Shuhui Bo, Hong Sun, Bei Liu, Zhaogang Sun, Hongqian Chu   +9 more
wiley   +1 more source

Automatic seismic fault detection and surface construction

Applied Computing and Geosciences
This paper proposes an effective approach for automatically building the fault model based on the 3D seismic images via two steps of automatic seismic fault detection and fault surface construction.
Xin Liu, Xingyu Zhu, Xupeng He, Yuzhu Wang   +3 more
doaj   +1 more source