Results 81 to 90 of about 370,062 (234)

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]

, 2018
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D, Chavez, Michael, Davis, Ryan R, Ferrara, Katherine W, Fite, Brett Z, Hubbard, Neil E, Ilovitsh, Asaf, Ingham, Elizabeth S, Mahakian, Lisa M, Monjazeb, Arta M, Murphy, William J, Silvestrini, Matthew T, Tam, Sarah M, Tepper, Clifford G   +13 more
core   +1 more source

Changes in the 2017 Pediatric Hypertension Clinical Guidelines. [PDF]

, 2018
The clinical practice guidelines on diagnosis and management of high blood pressure in children and adolescents have been periodically modified and updated since the original publication in 1977.1 Since the last pediatric blood pressure guideline was ...
Falkner, Bonita
core   +1 more source

Impact of rock mineralogy on reactive transport of CO2 during carbon sequestration in a saline aquifer

Journal of Petroleum Exploration and Production Technology
Deep saline aquifers offer a vast long-term storage capacity for CO2. The diverse mineral compositions in CO2 geological storage systems complicate the reactive transport of CO2.
Mohamed Gamal Rezk, Ahmed Farid Ibrahim
doaj   +1 more source

Eicosapentaenoic acid induces DNA demethylation in carcinoma cells through a TET1-dependent mechanism [PDF]

, 2018
In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes.
Billi, Monia, Cannarile, Lorenza, Ceccarelli, Veronica, Grignani, Francesco, Ottini, Laura, Riccardi, Carlo, Ronchetti, Simona, Talesa, Vincenzo Nicola, Valentini, Virginia, Vecchini, Alba   +9 more
core   +1 more source

DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy

Aging, 2016
DNA-methylation (DNAm) levels at age-associated CpG sites can be combined into epigenetic aging signatures to estimate donor age. It has been demonstrated that the difference between such epigenetic age-predictions and chronological age is indicative for
Qiong Lin, C. I. Weidner, Ivan G. Costa, R. Marioni, Marcelo R. P. Ferreira, I. Deary, W. Wagner   +6 more
semanticscholar   +1 more source

Induction of Robust Immune Responses by CpG-ODN-Loaded Hollow Polymeric Nanoparticles for Antiviral and Vaccine Applications in Chickens

International Journal of Nanomedicine, 2020
Shu-Yi Lin,1 Bing-Yu Yao,2 Che-Ming Jack Hu,2,3 Hui-Wen Chen1,3 1Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan; 2Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 3Research Center for Nanotechnology and ...
Lin SY, Yao BY, Hu CMJ, Chen HW
doaj  

CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies

International Journal of Nanomedicine, 2017
Unmethylated cytosine-guanine dinucleotide-containing oligodeoxynucleotides (CpG ODNs), which are synthetic agonists of Toll-like receptor 9 (TLR9), activate humoral and cellular immunity and are being developed as vaccine adjuvants to prevent or treat ...
N. Hanagata
semanticscholar   +1 more source

Correction to: Probabilistic estimation of hydraulic fracture half-lengths: validating the Gaussian pressure-transient method with the traditional rate transient analysis-method (Wolfcamp case study)

Journal of Petroleum Exploration and Production Technology, 2023
Dandi Alvayed, Mohammed Sofian Ali Khalid, Moaz Dafaalla, Ahmed Ali, Ahmed Farid Ibrahim, Ruud Weijermars   +5 more
doaj   +1 more source

DNA methylation in human epigenomes depends on local topology of CpG sites

Nucleic Acids Research, 2016
In vertebrates, methylation of cytosine at CpG sequences is implicated in stable and heritable patterns of gene expression. The classical model for inheritance, in which individual CpG sites are independent, provides no explanation for the observed non ...
Cecilia Lövkvist, I. Dodd, K. Sneppen, J. Haerter   +3 more
semanticscholar   +1 more source

Addressing the challenge of neonatal mortality.

, 2013
Reducing neonatal mortality remains a challenge with an estimated 3.0 million neonatal deaths in 2011, three-quarters of these in sub-Saharan Africa and Southern Asia.
Blencowe, H, Cousens, S
core   +1 more source