Results 81 to 90 of about 152,781 (323)

Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma

Advanced Materials, EarlyView.
A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura, Alessio Malfanti, Ana I Matos, Carina Peres, Ana Armiñán, Aroa Duro‐Castaño, Inmaculada Conejos‐Sánchez, María Medel, Snežana Đorđević, Paula Carrascosa, Bárbara Carreira, Rita C Acúrcio, Helena Xavier‐Ferreira, Alberto Hernández‐Barranco, Elena Castellano, Esther Roselló, José C. Machado, Héctor Peinado, María J. Vicent, Helena F. Florindo   +19 more
wiley   +1 more source

A postpartum enriched environment rescues impaired cognition and oxidative markers in aged mice with gestational inflammation

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Protein cysteine residues can be oxidized by nitric oxide (NO) to form protein S‐nitrosothiols (SNOs) in a process called S‐nitrosylation. S‐nitrosoglutathione reductase (GSNOR) is a highly specific denitrase for GSNO; it controls the intracellular levels of GSNO and protein SNOs and protects the body from nitrosative stress.
Yu‐Xin Zhang, Qi‐Yao Wei, Ya‐Tao Wang, Li‐Ping Zeng, Shi‐Yu Sun, Yong‐Fang Wu, Chong‐Yang Ren, Fang Wang, Gui‐Hai Chen, Lei Cao   +9 more
wiley   +1 more source

Leveraging petrophysical and geological constraints for AI-driven predictions of total organic carbon (TOC) and hardness in unconventional reservoir prospects

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
Key parameters for evaluating shale reservoirs include total organic carbon (TOC), thermal maturity, and hardness, the latter influencing fracture development and being crucial for managing ultralow permeability reservoirs.
Nandito Davy, Ammar El-Husseiny, Umair bin Waheed, Korhan Ayranci, Manzar Fawad, Mohamed Mahmoud, Nicholas B. Harris   +6 more
doaj   +1 more source

CpG DNA as a vaccine adjuvant [PDF]

Expert Review of Vaccines, 2011
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger cells that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) to mount an innate immune response characterized by the production of Th1 and proinflammatory cytokines.
Dennis M. Klinman, Takeshi Kinjo, Gan Zhao, Folkert Steinhagen, Christian Bode   +4 more
openaire   +3 more sources

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Impact of rock mineralogy on reactive transport of CO2 during carbon sequestration in a saline aquifer

Journal of Petroleum Exploration and Production Technology
Deep saline aquifers offer a vast long-term storage capacity for CO2. The diverse mineral compositions in CO2 geological storage systems complicate the reactive transport of CO2.
Mohamed Gamal Rezk, Ahmed Farid Ibrahim
doaj   +1 more source

Identifying Epigenetic Signature of Breast Cancer with Machine Learning [PDF]

arXiv, 2019
The research reported in this paper identifies the epigenetic biomarker (methylation beta pattern) of breast cancer. Many cancers are triggered by abnormal gene expression levels caused by aberrant methylation of CpG sites in the DNA. In order to develop early diagnostics of cancer-causing methylations and to develop a treatment, it is necessary to ...
arxiv  

Frequency‐Dependent Demethylation of Cancer DNAs by High‐Power Terahertz Radiation

Advanced Photonics Research, EarlyView.
Effective demethylation of cancer DNA is successfully demonstrated by resonant irradiation with high‐power terahertz (THz) waves at the 10 mW level, combined with metamaterial‐based THz filters. The dependence of spectral filtering on demethylation indicates that the resonant frequency of 1.6 THz of cancer DNAs plays a crucial role in reducing the ...
Chaeyoon Kim, Seung Won Jin, Seong Cheol Lee, Donghak Oh, Soojeong Baek, Bumki Min, Hee‐Jin Yang, Joo‐Hiuk Son, Fabian Rotermund   +8 more
wiley   +1 more source

CpG islands and the regulation of transcription [PDF]

Genes & Development, 2011
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by being GC-rich, CpG-rich, and predominantly nonmethylated. Most, perhaps all, CGIs are sites of transcription initiation, including thousands that are remote from currently annotated promoters.
Deaton, Aimee M., Bird, Adrian
openaire   +4 more sources

Performance of Liquid Biopsy‐Based Multi‐Omics Biomarkers for Early Detection of Gynecological Malignancies: A Prospective Study (PERCEIVE‐I)

Advanced Science, EarlyView.
Following a comparative analysis of omics‐based cancer detection models, a novel liquid biopsy‐based multi‐omics combined model is developed for the early detection of gynecological malignancies. By integrating cell‐free DNA methylation and tumor protein markers, the combined model demonstrates high specificity and sensitivity and is uniquely designed ...
Zheng Feng, Huijuan Ge, Jingshu Wang, Yanan Wang, Xiaoran Sun, Bo Yang, Siyu Cao, Chenlian Quan, Qinhao Guo, Yusheng Han, Feidie Duan, Fang liu, Jing Zhao, Guoqiang Wang, Yuzi Zhang, Shangli Cai, Xiaohua Wu, Hao Wen   +17 more
wiley   +1 more source