Results 101 to 110 of about 869,007 (330)

5‐Aza combined with VPA reprograms human T lineage acute leukemia Jurkat cells into B‐cell‐like cells by epigenetic activation of PAX5

Biotechnology Progress, EarlyView.
Abstract Epigenetic regulation plays an important role in cell fate reprogramming. Here, we found that inhibitors of epigenetic modifiers, including VPA, TSA, and 5‐Aza‐2'‐deoxycytidine, can induce phenotypic transformation from Jurkat cells into B‐cell‐like cells. When Jurkat cells were treated with 5‐Aza combined with VPA, B cell and stem cell marker
Wenjin Xi, Guoxu Zheng, Xu Chen, Baile Zuo, Wei Wang, Yufang Li, Chunmei Zhang, Jie Chu, Xiuli Mu, Weihong Wen, Tao Wang, An‐Gang Yang   +11 more
wiley   +1 more source

Learning Quadruped Locomotion using Bio-Inspired Neural Networks with Intrinsic Rhythmicity [PDF]

arXiv, 2023
Biological studies reveal that neural circuits located at the spinal cord called central pattern generator (CPG) oscillates and generates rhythmic signals, which are the underlying mechanism responsible for rhythmic locomotion behaviors of animals.
arxiv  

A Deep Autoencoder System for Differentiation of Cancer Types Based on DNA Methylation State [PDF]

arXiv, 2018
A Deep Autoencoder based content retrieval algorithm is proposed for prediction and differentiation of cancer types based on the presence of epigenetic patterns of DNA methylation identified in genetic regions known as CpG islands. The developed deep learning system uses a CpG island state classification sub-system to complete sets of missing ...
arxiv  

CpGIMethPred: computational model for predicting methylation status of CpG islands in human genome

BMC Medical Genomics, 2013
DNA methylation is an inheritable chemical modification of cytosine, and represents one of the most important epigenetic events. Computational prediction of the DNA methylation status can be employed to speed up the genome-wide methylation profiling, and
Hao Zheng, Hongwei Wu, Jinping Li, Shi-Wen Jiang   +3 more
semanticscholar   +1 more source

CpG island chromatin [PDF]

Epigenetics, 2011
The majority of mammalian gene promoters are encompassed within regions of the genome called CpG islands that have an elevated level of non-methylated CpG dinucleotides. Despite over 20 years of study, the precise mechanisms by which CpG islands contribute to regulatory element function remain poorly understood.
Blackledge, N, Klose, R
openaire   +3 more sources

Genome-scale computational analysis of DNA curvature and repeats in Arabidopsis and rice uncovers plant-specific genomic properties

BMC Genomics, 2011
Background Due to its overarching role in genome function, sequence-dependent DNA curvature continues to attract great attention. The DNA double helix is not a rigid cylinder, but presents both curvature and flexibility in different regions, depending on
Jáuregui Ruy, Movahedi Sara, Masoudi-Nejad Ali   +2 more
doaj   +1 more source

Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy

ChemPlusChem, Accepted Article.
The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source

Nonlinear Modeling Approach to Human Promoter Sequences [PDF]

Journal of Theoretical Biology 241 (2006) 765?C773, 2005
By means of the nonlinear modeling technique (NM technique), we find the nonlinear deterministic structures in the promoter regions (PPRs) of DNA sequences, called deterministic valleys (DVs) in this paper. These DVs prefer to occur much more outside of a special region around TSS. The number, positions and shapes of the DVs are basically different for
arxiv  

Aberrant CpG Islands’ Hypermethylation of ABCB1 in Mesenchymal Stem Cells of Patients with Steroid-associated Osteonecrosis

Journal of Rheumatology, 2013
Objective. Patients carrying an ABCB1 polymorphism have a higher risk of developing osteonecrosis of the femoral head (ONFH). We investigated whether aberrant dinucleotide CpG islands’ hypermethylation of ABCB1 gene existed in mesenchymal stem cells (MSC)
Zhibo Sun, Shuhua Yang, Shunan Ye, Yukun Zhang, Weihua Xu, Bo Zhang, Xianzhe Liu, Fengbo Mo, Wenbin Hua   +8 more
semanticscholar   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source