Results 111 to 120 of about 869,007 (330)
Frontiers in Neuroscience, 2010 Genome wide methylation profiling of gliomas is likely to provide important clues to improving treatment outcomes. Restriction enzyme based approaches have been widely utilized for methylation profiling of cancer genomes and will continue to have ...
Anh Tran +12 more
doaj +1 more source
DNA methylation determines nucleosome occupancy in the 5′-CpG islands of tumor suppressor genes
Oncogene, 2013 Promoter CpG island hypermethylation of tumor suppressor genes is an epigenetic hallmark of human cancer commonly associated with nucleosome occupancy and the transcriptional silencing of the neighboring gene. Nucleosomes can determine the underlying DNA
A. Portela +5 more
semanticscholar +1 more source
Diversity of core promoter elements comprising human bidirectional promoters
BMC Genomics, 2008 Background Bidirectional promoters lie between adjacent genes, which are transcribed from opposite strands of DNA. The functional mechanisms underlying the activation of bidirectional promoters are currently uncharacterised.
Elnitski Laura L, Yang Mary
doaj +1 more source
Computing the likelihood of sequence segmentation under Markov modelling [PDF]
arXiv, 2009 I tackle the problem of partitioning a sequence into homogeneous segments, where homogeneity is defined by a set of Markov models. The problem is to study the likelihood that a sequence is divided into a given number of segments. Here, the moments of this likelihood are computed through an efficient algorithm.
arxiv
Nucleic Acids Research, 2013 The heterogeneous collection of nucleosome remodelling and deacetylation (NuRD) complexes can be grouped into the MBD2- or MBD3-containing complexes MBD2–NuRD and MBD3–NuRD.
K. Günther +7 more
semanticscholar +1 more source
Head &Neck, EarlyView.ABSTRACT Background The detection rate of oncogenic human papillomaviruses (HPVs) in sinonasal squamous cell carcinomas (SNSCCs) varies among studies. The mutational landscape of SNSCCs remains poorly investigated. Methods We investigated the prevalence and prognostic significance of HPV infections based on p16 protein expression, HPV‐DNA detection ...
Maxime Henrion +8 more
wiley +1 more source
An annotated list of bivalent chromatin regions in human ES cells: a new tool for cancer epigenetic research [PDF]
Oncotarget, Impact journals, 2017, 8, pp.4110 - 4124, 2018 CpG islands (CGI) marked by bivalent chromatin in stem cells are believed to be more prone to aberrant DNA methylation in tumor cells. The robustness and genome-wide extent of this instructive program in different cancer types remain to be determined.
arxiv
Orphan CpG Islands Identify Numerous Conserved Promoters in the Mammalian Genome
PLoS Genetics, 2010 CpG islands (CGIs) are vertebrate genomic landmarks that encompass the promoters of most genes and often lack DNA methylation. Querying their apparent importance, the number of CGIs is reported to vary widely in different species and many do not co ...
Robert S. Illingworth +9 more
semanticscholar +1 more source
A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research
International Journal of Cancer, EarlyView.Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez +2 more
wiley +1 more source
Next Generation Epigenetic Detection Technique:Identifying Methylated DNA using Graphene Nanopore [PDF]
arXiv, 2014 DNA methylation plays a pivotal role in the genetic evolution of both embryonic and adult cells. For adult somatic cells, location and dynamics of methylation has been very precisely pinned down with the 5-cytosine markers on cytosinephosphate- guanine (CpG) units.
arxiv