Results 81 to 90 of about 146 (99)

Disruption of CPSF6 enhances cellular permissivity to HIV-1 infection through alternative polyadenylation

Abstract Human immunodeficiency virus (HIV) relies upon a broad array of host factors in order to replicate and evade the host antiviral response1. Cleavage and polyadenylation specificity factor 6 (CPSF6) is one such host factor that is recruited by incoming HIV-1 cores to regulate trafficking2, nuclear import3-5, uncoating6, and integration ...
Judd Hultquist, Daphne Cornish, Kathryn Jackson-Jones, Ted Ling-Hu, Lacy Simons, William Cisneros, Edmund Kuffour, Francesca Agnes, Yujin Lee, Paul Bieniasz, Ramon Lorenzo-Redondo   +10 more
openaire   +2 more sources

Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with the nuclear speckle

Summary Viruses rely on host cellular machinery for replication. After entering the nucleus, the HIV genome accumulates in nuclear niches where it undergoes reverse transcription and integrates into neighboring chromatin, promoting high transcription rates and new virus progeny.
Celine Cuche, Chiara Tomasini, Selen Ay, Maxence Collard, Bin Cui, Mohammad Rashid, Shaoni Bhattacharjee, Bruno Tello-Rubio, Julian Buchrieser, Charlotte Luchsinger, Cinzia Bertelli, Vladimir N Uversky, Felipe Diaz-Griffero, Francesca Di Nunzio   +13 more
openaire   +3 more sources

SNW1 promotes lymphatic metastasis in bladder cancer by modulating SRPK1 splicing

iScience
Summary: The overall survival of patients with metastatic bladder cancer (BCa) remains poor. There is a lack of effective therapies and reliable biomarkers for metastatic BCa. BCa cells initially disseminate via the pelvic lymph nodes (LN).
Jijie Hu, Ying Zhu, Guoli Wang, Huiqi Dai, Haoyuan Han, Wenmin Cao, Meng Ding, Wenli Diao, Qun Lu, Qing Zhang, Hongqian Guo, Wei Chen   +11 more
doaj   +1 more source

E3 ligase SYVN1-mediated polyubiquitination of CPSF6 promotes alternative polyadenylation and antivirus effects of macrophages

Cell Reports
Transcriptome-wide alternative polyadenylation (APA) is involved in both innate and adaptive immune responses of immune cells. Downregulation of the CPSF6 protein, one of the 3' end-processing factors, mediates APA in macrophages with responses to virus infection and plays an important role in its anti-virus effect.
Xin Lu, Chao Liu, Runze Wu, Zhijie Hu, Susu Liu, Xuening Li, Yuchi Liu, Mengxia Li, Jingting Liang, Yingye Huang, Yuting Han, Xin Ou, Ke Deng, Cheng Liang, Shangwu Chen, Yonggui Fu, Anlong Xu   +16 more
openaire   +2 more sources

Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM

Cell Reports
Summary: One of the striking features of human immunodeficiency virus (HIV) is the capsid, a fullerene cone comprised of pleomorphic capsid protein (CA) that shields the viral genome and recruits cofactors.
Matthew Cook, Christian Freniere, Chunxiang Wu, Faith Lozano, Yong Xiong   +4 more
doaj   +1 more source

Retraction note to: RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer

World Journal of Gastrointestinal Oncology
The authors have decided to retract the article published on World J Gastrointest Oncol (2023) for further consideration due to data errors and some misunderstandings in communication.
Wang, Xue-Jun, Liu, Yong, Ke, Bin, Zhang, Li, Liang, Han   +4 more
openaire   +1 more source

EHA2024 Hybrid Congress

HemaSphere, Volume 8, Issue S1, June 2024.
wiley   +1 more source

Inhibiting circ_0000673 blocks the progression of colorectal cancer through downregulating CPSF6 via targeting miR-548b-3p

Advances in Clinical and Experimental Medicine
Colorectal cancer (CRC) is one of the most common cancers, and its progression is regulated by several factors, including circular RNA (circRNA).The objective of this study was to determine the role, or roles, of circ_0000673 in CRC.We used quantitative real-time polymerase chain reaction (qPCR) to detect the expression of circ_0000673, miR-548b-3p and
Shuang, Li, Tuoyun, Yang, Lu, Liu, Baorong, Hu, Xi, Chen, Wenting, Zhao, Xin, Hai   +6 more
openaire   +2 more sources

Cleavage and polyadenylation specific factor 6 (CPSF6); cyclophilin A (CYPA; PPIA) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Κλωνοποίηση και αποτίμηση της βιολογικής σημασίας του παράγοντα πολυαδενυλίωσης CPSF6

, 2016
openaire   +1 more source